Pheochromocytoma

Minno, Alexander M.; Bennett, Warren A.; Kvale, Walter F.

doi:10.1056/nejm195412092512401

Cited by 84 publications

(8 citation statements)

References 19 publications

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“…However, when a catecholamine-producing tumor is discovered, expectant management is not appropriate. Besides the undesirable effects of sustained elevated blood pressure, these tumors can produce hypertensive emergencies, with potentially life-threatening cardiovascular consequences (2). An autopsy study reported that 75% of deaths related to phaeochromocytoma were due to a myocardial infarction or cerebral vascular accident (14), emphasizing the importance of interventional treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Phaeochromocytoma is a neuroendocrine tumor with a prevalence ranging from 0.05% to 0.1% (1, 2). Phaeochromocytomas are located in the adrenal cortex in 85% of cases (2).…”

Section: Introductionmentioning

confidence: 99%

“…Phaeochromocytomas are located in the adrenal cortex in 85% of cases (2). The main clinical manifestation of phaeochromocytomas is arterial hypertension, which is the result of uncontrolled production of catecholamines by the tumor.…”

Section: Introductionmentioning

confidence: 99%

“…The main clinical manifestation of phaeochromocytomas is arterial hypertension, which is the result of uncontrolled production of catecholamines by the tumor. It is estimated that 0.1% to 0.6% of all patients with hypertension have an underlying phaeochromocytoma (2, 3). Moreover, catecholamine-producing neoplasms can lead to hypertensive emergencies with life-threatening consequences; thus, this tumor has major clinical importance (2, 4).…”

Section: Introductionmentioning

confidence: 99%

“…However, phaeochromocytomas also affect children and the elderly, with sporadic cases being more common in older patients (2). Furthermore, with recent increases in life expectancy and improvements in imaging techniques, there has been an increase in the number of incidental diagnoses of phaeochromocytoma in older individuals undergoing periodic routine check-ups (6).…”

Section: Introductionmentioning

confidence: 99%

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Presentation and surgery outcomes in elderly with pheocromocytoma: a comparative analysis with young patients

et al. 2016

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Purpose:To evaluate the presentation and early surgical outcomes of elderly patients undergoing adrenalectomy for phaeochromocytoma.Patients and Methods:A retrospective search was performed of our adrenal disorders database for patients who underwent surgery for phaeochromocytoma or paraganglioma between 2009 and 2014. Patients >60 years old were classified as elderly. The clinical manifestations, intraoperative course, and early postoperative outcomes of elderly patients were compared to those of younger individuals (<60 years old).Results:The mean (±standard deviation) age in the older (n=10) and younger (n=36) groups was 69.6±5.3 years and 34.0±12.9 years. Germ-line mutations were more common in younger patients (50.0% versus 0%; p=0.004), whereas incidental lesions were more common in the elderly (40.0% versus 5.3%; p=0.003). In both groups, surgery was most commonly performed by videolaparoscopy (90% in the elderly and 82% in the younger group), with similar intraoperative anesthetic and surgical outcomes. Postoperatively, the older group more commonly received vasoactive drugs (60.0% versus 10.5%; p<0.001) and had a longer intensive care unit stay (3.1±2.8 versus 1.4±1.0 days; p=0.014), more clinical complications (60% versus 18.9%; p=0.01), and longer hospital stay (10.2±8.4 versus 5.7±4.9 days; p=0.028).Conclusions:Although all patients received the same preoperative preparation, the elderly group exhibited a slower and more complicated recovery after adrenalectomy. Meticulous perioperative care should be used in the elderly when treating phaeochromocytoma; nevertheless, adrenalectomy is a relatively safe procedure in this patient population.

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Section: Discussionmentioning

confidence: 99%

“…Phaeochromocytoma is a neuroendocrine tumor with a prevalence ranging from 0.05% to 0.1% (1, 2). Phaeochromocytomas are located in the adrenal cortex in 85% of cases (2).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%