Pheochromocytoma Characterizing Both Fever and Acute Renal Failure

Jin, Yansheng; Fan, Maoxiao

doi:10.4103/0366-6999.200543

Cited by 5 publications

(4 citation statements)

References 3 publications

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“…The mass was resected and consistent with a pheochromocytoma and the patient's fevers ceased after the adrenalectomy. Jin et al [ 8 ] describe the case of a 66-year-old male with intermittent fevers and nonoliguric acute renal failure. He was noted on imaging to have a mass in the left adrenal gland which was found to be a pheochromocytoma, and he had normalization of symptoms after adrenalectomy.…”

Section: Discussionmentioning

confidence: 99%

Fever of Unknown Origin: Could It Be a Pheochromocytoma? A Case Report and Review of the Literature

Siddiqui

Matta

Wessolossky

et al. 2018

Case Reports in Endocrinology

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Pheochromocytomas are rare tumors that arise from the adrenal medulla, with an incidence of less than 1 per 100,000 person-years. These tumors are characterized by excess catecholamine secretion and classically present with the triad of headaches, palpitations, and sweating episodes. However, the clinical presentation can be quite variable. Herein, we present a patient who presented with persistent fevers. An adrenal mass was incidentally discovered during the extensive investigation for the fever of unknown origin. Consequently, blood and urine tests were done and found to be consistent with a pheochromocytoma. The resection of this pheochromocytoma resulted in resolution of fevers. It is hypothesized that fevers in patients with pheochromocytomas occur due to the excess catecholamine or possibly due to interleukins. This clinical presentation serves as a learning point that adrenal incidentalomas in the setting of fever of unknown origin should not be ignored. It also reminds clinicians that pheochromocytomas which present with fevers may have tumor necrosis and many such patients are at risk for multisystem crises.

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Section: Discussionmentioning

confidence: 99%

Fever of Unknown Origin: Could It Be a Pheochromocytoma? A Case Report and Review of the Literature

Siddiqui

Matta

Wessolossky

et al. 2018

Case Reports in Endocrinology

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“…Renal injury is a rare complication associated with PPGL resection. The mechanism of renal injury is due to massive catecholamine release in the postoperative period that can potentially lead to: (1) Stimulatory effects on renin activity and (2) hypertensive crisis from severe vasoconstriction leading to hypoperfusion at the renal bed, ischemia, and necrosis of skeletal muscles provoking rhabdomyolysis [110,111]. In contrast, hypotension due to a rapid drop in catecholamine levels, or intravascular volume depletion, can lead to acute tubular necrosis [111].…”

Section: Other Complicationsmentioning

confidence: 99%

Postoperative Management in Patients with Pheochromocytoma and Paraganglioma

Mamilla

Araque

Brofferio

et al. 2019

Cancers

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Pheochromocytomas and paragangliomas (PPGLs) are rare catecholamine-secreting neuroendocrine tumors of the adrenal medulla and sympathetic/parasympathetic ganglion cells, respectively. Excessive release of catecholamines leads to episodic symptoms and signs of PPGL, which include hypertension, headache, palpitations, and diaphoresis. Intraoperatively, large amounts of catecholamines are released into the bloodstream through handling and manipulation of the tumor(s). In contrast, there could also be an abrupt decline in catecholamine levels after tumor resection. Because of such binary manifestations of PPGL, patients may develop perplexing and substantially devastating cardiovascular complications during the perioperative period. These complications include hypertension, hypotension, arrhythmias, myocardial infarction, heart failure, and cerebrovascular accident. Other complications seen in the postoperative period include fever, hypoglycemia, cortisol deficiency, urinary retention, etc. In the interest of safe patient care, such emergencies require precise diagnosis and treatment. Surgeons, anesthesiologists, and intensivists must be aware of the clinical manifestations and complications associated with a sudden increase or decrease in catecholamine levels and should work closely together to be able to provide appropriate management to minimize morbidity and mortality associated with PPGLs.

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“…Острое почечное повреждение, вероятно, было обусловлено выраженной вазоконстрикцией и ишемией почечной паренхимы на фоне гиперкатехоламинемии. Наши данные подтверждаются описанием единичных случаев острой почечной недостаточности, связанных с феохромоцитомой [6].…”

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Pheochromocytoma associated with neurofibromatosis type 1: a clinical case

et al. 2019

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A clinical case of pheochromocytoma in combination with neurofibromatosis type 1 is presented in a man admitted to the cardiology department with acute coronary syndrome on the background of hypertensive crisis. The crisis was complicated by myocardial ischemia, myeloid leukemoid reaction, hyperglycemia and acute renal damage. Pheochromocytoma was verified by blood metabolites of catecholamines test and histological method. Surgical adrenalectomy was performed.

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Pheochromocytoma Characterizing Both Fever and Acute Renal Failure

Cited by 5 publications

References 3 publications

Fever of Unknown Origin: Could It Be a Pheochromocytoma? A Case Report and Review of the Literature

Fever of Unknown Origin: Could It Be a Pheochromocytoma? A Case Report and Review of the Literature

Postoperative Management in Patients with Pheochromocytoma and Paraganglioma

Pheochromocytoma associated with neurofibromatosis type 1: a clinical case

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