Pheochromocytoma presenting as fulminant myocarditis mimicking COVID‐19 pneumonia

Rojbi, I.; Adel, Meriem; Affes, M.; Hantous, Saoussen; Jrad, M.; Naçef, I. Ben; Khiari, K.

doi:10.1002/ccr3.5046

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…Likewise, Wu et al detailed a case involving two middle-aged males with acute myocarditis and cardiogenic shock, necessitating an intra-aortic balloon pump (IABP) and ECMO for life support, ultimately unmasking the presence of a pheochromocytoma (19). In the same vein, Rojbi I et al documented a case of a 40-year-old female with symptoms suggestive of fulminant myocarditis and COVID-19 pneumonia, later attributed to a pheochromocytoma (20). These cases collectively reiterate the diagnostic hurdles posed by pheochromocytoma mimicking fulminant myocarditis.…”

Section: Discussionmentioning

confidence: 99%

A case report on pheochromocytoma mimicking as fulminant myocarditis—a diagnostic challenge

Cheng,

Ding,

Wang

et al. 2024

Front. Cardiovasc. Med.

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We present an exceptional case of a 53-year-old female, initially misdiagnosed with fulminant myocarditis, but later correctly diagnosed with pheochromocytoma. The presentation of the patient included a spectrum of symptoms such as headache, chest discomfort, palpitations, and dyspnea, following the intake of Domperidone. Two weeks prior to admission, the patient had experienced episodes of diarrhea and a low-grade fever. Unresolved symptoms and an unmanageable surge in blood pressure despite comprehensive fulminant myocarditis treatment prompted further investigation. The discovery of an adrenal mass via a CT scan and subsequent biochemical tests led to the confirmation of pheochromocytoma. Implementation of alpha-blockade therapy and a successful laparoscopic adrenalectomy resulted in significant clinical improvement. This case underscores the diagnostic intricacies of pheochromocytoma and highlights the need for vigilance when faced with severe, unresponsive cardiovascular symptoms.

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Section: Discussionmentioning

confidence: 99%

A case report on pheochromocytoma mimicking as fulminant myocarditis—a diagnostic challenge

Cheng,

Ding,

Wang

et al. 2024

Front. Cardiovasc. Med.

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“…Even though pheochromocytoma is a rare condition, if a young patient presents with unexplained cardiac dysfunction, we should consider pheochromocytoma [ 7 ]. The prognosis of pheochromocytoma-induced cardiac diseases depends on early diagnosis and treatment [ 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

First Presentation of Pheochromocytoma As Acute Myocarditis in Otherwise Young Healthy Man

Shalomi,

Ramesh

2023

Cureus

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Phaeochromocytoma is indeed a rare and frequently misunderstood neuroendocrine tumor originating from chromaffin cells in the adrenal medulla. Its clinical presentation often includes paroxysmal hypertension, palpitations, headache, and diaphoresis, which can easily be mistaken for common medical conditions. Timely diagnosis and precise localization are paramount for ensuring the best possible outcomes for patients. In this case report, we describe an unusual presentation of phaeochromocytoma in a 36-year-old man who presented with acute myocarditis. This atypical manifestation underscores the diagnostic challenges associated with phaeochromocytoma, as its symptoms can mimic various other cardiac and non-cardiac conditions. Vigilant clinical evaluation and a multidisciplinary approach are essential for promptly recognizing and managing such cases, thus optimizing patient care and prognosis.

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“…As just one example, recent studies provide indirect evidence that succinate-dependent cytokine response may be a central feature of the severe- and long-COVID that hallmarks a subset of SARS-CoV2 infections. In fact, there is some overlap between the symptoms of complex II deficiency and some of the unusual symptoms of COVID ( 183 , 184 , 185 ). Cell-permeable diethyl succinate boosts viral load ( 186 ), while metabolomics identified that succinate accumulation profoundly increases with disease severity ( 187 ).…”

Section: Succinate Signaling Regulation Of Transcription and Cell Fatementioning

confidence: 99%

An evolving view of complex II—noncanonical complexes, megacomplexes, respiration, signaling, and beyond

Iverson¹,

Singh²,

Cecchini³

2023

Journal of Biological Chemistry

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Pheochromocytoma presenting as fulminant myocarditis mimicking COVID‐19 pneumonia

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 5 publications

References 12 publications

A case report on pheochromocytoma mimicking as fulminant myocarditis—a diagnostic challenge

A case report on pheochromocytoma mimicking as fulminant myocarditis—a diagnostic challenge

First Presentation of Pheochromocytoma As Acute Myocarditis in Otherwise Young Healthy Man

An evolving view of complex II—noncanonical complexes, megacomplexes, respiration, signaling, and beyond

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