Pheochromocytoma With Hypermetabolism Report of Two Cases

The Early Diagnosis of Pheochromocytoma

“…Pheochromocytoma has also been found with frank diabetes mellitus (McCullagh, 1942). Retinal changes do not differ from those found in benign or malignant hypertension.…”

“…The basal metabolic rate perhaps comes next in order of importance for this is often above 20 per cent (Binger, 1938, andMcCullagh, 1942) and indeed the differential diagnosis from hyperthyroidism may be very difficult and has often led to confusion. This is not surprising, for the clinical resemblance between excessive secretion of adrenalin, chronic anxiety, and hyperthyroidism may be very ,close.…”

“…It is less generally known that pheochromocytoma may produce a picture without paroxysms, closely resembling benign or malignant hypertension, but this had been pointed out by many writers (Binger and Craig, 1938;Thorn, Hindle, and Sandmeyer, 1944;Palmer and Castleman, 1938;McCullagh and Engel, 1942;and Mackeith, 1944). That persistent hypertension is a good deal commoner than has been realized, is suggested by Green (1946) who in a recent review of 51 cases of pheochromocytoma found that only 14 showed intermittent hypertension, while 37 had chronic hypertension.…”

Energy metabolism in amyotrophic lateral sclerosis: assessment of body composition and energy expenditure

“…Clinical conditions characteristically associated with hypermetabolism include hyperthyroidism McAuliffe, 1989), pheochromocytoma (McCullagh andEngel, 1942), malignancy (Purcell et al, 2016), burns (Auger et al, 2017) and significant trauma (Rogobete et al, 2017). Given reports of hypermetabolism in ALS, the clinical consequences and possible mechanisms of hypermetabolism in other disorders will be considered.…”

“…Endogenous catecholamines, which increase adrenergic stress, are thought to be the primary mediators of hypermetabolism in pheochromocytoma (McCullagh and Engel, 1942), trauma and burns (Reiss et al, 1956, Wilmore et al, 1974, Porter et al, 2014.…”