Pheophorbide-a conjugates with cancer-targeting moieties for targeted photodynamic cancer therapy

You, Hyun Ju; Yoon, Hyo-Eun; Jeong, Pyeonghwa; Ko, Hyojin; Yoon, Jung‐Hoon; Kim, Yong-Chul

doi:10.1016/j.bmc.2015.02.014

Cited by 45 publications

(25 citation statements)

References 25 publications

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“…20%. Our results are in line with what reported earlier in literature for different constructs[91][92][93][94][95], indicating that synergistic chemo-photodynamic therapy mediated by diatom microalgae is a strategy worthwhile pursuing in colon-focused drug delivery. It is well known that undesirable side effects of most chemotherapeutics like cisplatin are dose dependent[96], thus this approach can reduce the need of chemotherapeutics concentration for equal effectiveness hence leading to diminished undesirable side effects for the patient.…”

supporting

confidence: 92%

Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes

Delasoie¹,

Schiel²,

Vojnović³

et al. 2020

Preprint

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Design, synthesis and characterization of a bio-inspired hybrid multifunctional drug delivery system based on diatom microalgae. The microalgae’s surface was chemically functionalized with hybrid vitamin B<sub>12</sub>-photoactivable molecules and the materials further loaded with highly active rhenium(I) tricarbonyl anticancer complexes. The constructs showed enhanced adherence to colorectal cancer (CRC) cells via transcobalamin (II) receptors and slow release of the chemotherapeutic drugs. The overall toxicity of the hybrid multifunctional drug delivery system was further enhanced by photoactivation of the microalgae surface. Depending on the construct and anticancer drug, a 2-fold increase in the cytotoxic efficacy of the drug was observed upon light irradiation.

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supporting

confidence: 92%

Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes

Delasoie¹,

Schiel²,

Vojnović³

et al. 2020

Preprint

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“…The intention is to rely on the ability of the targeting vehicle to control localization so that the PS can be chosen based on its photochemical properties rather than on its tumour targeting properties, which are often unimpressive. These targeting vehicles include monoclonal antibodies [74], antibody fragments [75], peptides [76], proteins such as transferrin [77], epidermal growth factor [77] and insulin [78], LDL [79], various carbohydrates [80], somatostatin [81], folic acid [82] and many others. Table 4 lists some of these targeting ligand–PS conjugates.…”

Section: Targeted Pdtmentioning

confidence: 99%

New photosensitizers for photodynamic therapy

Abrahamse

Hamblin

2016

Biochemical Journal

1,669

1,172

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Photodynamic therapy (PDT) was discovered more than 100 years ago, and has since become a well-studied therapy for cancer and various non-malignant diseases including infections. PDT uses photosensitizers (PSs, non-toxic dyes) that are activated by absorption of visible light to initially form the excited singlet state, followed by transition to the long-lived excited triplet state. This triplet state can undergo photochemical reactions in the presence of oxygen to form reactive oxygen species (including singlet oxygen) that can destroy cancer cells, pathogenic microbes and unwanted tissue. The dual-specificity of PDT relies on accumulation of the PS in diseased tissue and also on localized light delivery. Tetrapyrrole structures such as porphyrins, chlorins, bacteriochlorins and phthalocyanines with appropriate functionalization have been widely investigated in PDT, and several compounds have received clinical approval. Other molecular structures including the synthetic dyes classes as phenothiazinium, squaraine and BODIPY (boron-dipyrromethene), transition metal complexes, and natural products such as hypericin, riboflavin and curcumin have been investigated. Targeted PDT uses PSs conjugated to antibodies, peptides, proteins and other ligands with specific cellular receptors. Nanotechnology has made a significant contribution to PDT, giving rise to approaches such as nanoparticle delivery, fullerene-based PSs, titania photocatalysis, and the use of upconverting nanoparticles to increase light penetration into tissue. Future directions include photochemical internalization, genetically encoded protein PSs, theranostics, two-photon absorption PDT, and sonodynamic therapy using ultrasound.

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“…a). Targeting moieties used for this purpose include folic acid, peptides, antibodies and carbohydrates (Table ), and can be either conjugated to a nanoparticle or directly to a PS.…”

Section: Targeting the Tumor Microenvironment With Photochemistrymentioning

confidence: 99%

“…8a). Targeting moieties used for this purpose include folic acid, peptides, antibodies and carbohydrates (325)(326)(327)(328)(329)(330)(331)(332)(333)(334)(335)(336)(337)(338) (Table 3), and can be either conjugated to a nanoparticle or directly to a PS. Most PDT treatments that incorporate such targeting moieties are designed to directly target cancer cells.…”

Section: Targeted Deliverymentioning

confidence: 99%

Photodynamic Therapy and the Biophysics of the Tumor Microenvironment

Sorrin

Ruhi

Ferlic

et al. 2020

Photochem & Photobiology

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Targeting the tumor microenvironment (TME) provides opportunities to modulate tumor physiology, enhance the delivery of therapeutic agents, impact immune response and overcome resistance. Photodynamic therapy (PDT) is a photochemistry‐based, nonthermal modality that produces reactive molecular species at the site of light activation and is in the clinic for nononcologic and oncologic applications. The unique mechanisms and exquisite spatiotemporal control inherent to PDT enable selective modulation or destruction of the TME and cancer cells. Mechanical stress plays an important role in tumor growth and survival, with increasing implications for therapy design and drug delivery, but remains understudied in the context of PDT and PDT‐based combinations. This review describes pharmacoengineering and bioengineering approaches in PDT to target cellular and noncellular components of the TME, as well as molecular targets on tumor and tumor‐associated cells. Particular emphasis is placed on the role of mechanical stress in the context of targeted PDT regimens, and combinations, for primary and metastatic tumors.

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Pheophorbide-a conjugates with cancer-targeting moieties for targeted photodynamic cancer therapy

Cited by 45 publications

References 25 publications

Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes

Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes

New photosensitizers for photodynamic therapy

Photodynamic Therapy and the Biophysics of the Tumor Microenvironment

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