Phillyrin lowers body weight in obese mice via the modulation of PPAR&lt;beta&gt;/&lt;delta&gt;-ANGPTL 4 pathway

Xiao, Hong-Bo; Sui, Guo-Guang; Lu, Xiangyang

doi:10.1016/j.orcp.2017.02.002

Cited by 11 publications

(11 citation statements)

References 30 publications

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“…The aqueous extract of Forsythiae Fructus reduced the serum gastrin content and promoted gastrointestinal movement, demonstrating an anti-vomiting effect in mice exposed to chemotherapy [ 9 ]. Phillyrin ( 60 ) was shown to exert a remarkable antiobesity effect in high glucose-induced lipid accumulation in HepG2 cells and 3T3-L1 adipocytes, as well as in obese mice [ 149 , 150 , 151 ]. The mechanism of action was possibly due to inducing the liver kinase B1 (LKB1) phosphorylation and activating AMP-activated protein kinase (AMPK), thus reducing expression of sterol regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase.…”

Section: Pharmacologymentioning

confidence: 99%

Forsythiae Fructus: A Review on its Phytochemistry, Quality Control, Pharmacology and Pharmacokinetics

Zhao

Tong

et al. 2017

Molecules

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Forsythiae Fructus, as a traditional Chinese medicine, has been widely used both as a single herb and in compound prescriptions in Asia, mainly due to its heat-clearing and detoxifying effects. Modern pharmacology has proved Forsythiae Fructus possesses various therapeutic effects, both in vitro and in vivo, such as anti-inflammatory, antibacterial and antiviral activities. Up to now, three hundred and twenty-one compounds have been identified and sensitive analytical methods have been established for its quality control. Recently, the pharmacokinetics of Forsythiae Fructus and its bioactive compounds have been reported, providing valuable information for its clinical application. Therefore, this systematic review focused on the newest scientific reports on Forsythiae Fructus and extensively summarizes its phytochemistry, pharmacology, pharmacokinetics and standardization procedures, especially the difference between the two applied types—unripe Forsythiae Fructus and ripe Forsythiae Fructus—in the hope of providing a helpful reference and guide for its clinical applications and further studies.

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Section: Pharmacologymentioning

confidence: 99%

Forsythiae Fructus: A Review on its Phytochemistry, Quality Control, Pharmacology and Pharmacokinetics

Zhao

Tong

et al. 2017

Molecules

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“…Phillyrin, a major active component of Forsythia suspensa (Thunb. ), has various biological and pharmacological activities, including antiapoptotic, 22 antioxidative, 23 antiviral, 24,25 lipid reducing, 26 antiobesity 27 and anti-inflammatory activities. 28 However, no studies have addressed the effects and the underlying mechanisms of phillyrin in preventing and improving DN.…”

Section: Introductionmentioning

confidence: 99%

Phillyrin ameliorates diabetic nephropathy through the PI3K/Akt/GSK-3β signalling pathway in streptozotocin-induced diabetic mice

et al. 2021

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Diabetic nephropathy is a progressive kidney disease resulting from long-term hyperglycaemia in diabetic patients, and the underlying mechanism is complex and lacks effective treatments. Various active ingredients in Chinese herbs have been shown to alleviate renal injury and improve DN in recent years. Phillyrin, a natural medicinal active compound extracted from the Oleaceae family, has various pharmacological effects, including antioxidative, antiapoptotic and antiobesity effects. However, the role of phillyrin and its underlying mechanism in DN have not yet been explored. To investigate the effects of phillyrin on DN and its potential mechanisms of action, we performed experiments using streptozotocin (STZ)-induced DN mice as models. Phillyrin significantly reduced the levels of fasting blood glucose (FBG) and glycosylated haemoglobin A1c (HbA1c), downregulated the levels of serum blood urea nitrogen (BUN), serum creatinine (Scr), serum and urine β2-microglobulins (β2-MG) and improved the pathological changes of the kidney in a DN mouse model. Phillyrin also increased the level of antioxidants and attenuated oxidative damage in DN model mice. In addition, phillyrin inhibited Glycogen synthase kinase-3β (GSK-3β) activity by activating the PI3K/Akt signalling pathway, increased the Bcl-2/Bax ratio, reduced the release of cytochrome c from the mitochondria to the cytoplasm, subsequently inhibited the activation of caspase-3 and ultimately suppressed renal cell apoptosis. These findings suggested that phillyrin could be a new promising therapeutic strategy for DN, and this protective effect might be related to suppressing oxidative stress and apoptosis via the PI3K/Akt/GSK-3β pathway.

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“…However, despite that there are many in vivo data supporting the anti-obese action of phillyrin, few studies in the literature have covered the underlying mechanisms. Xiao et al speculated that phillyrin functioned as an AMPK activator, increasing the expression of PPARβ/δ and ANGPTL4 to promote fat metabolism and weight loss in HFD mice [20]. In addition, by using molecular docking technology, phillyrin was identified as an inhibitor of phosphodiesterase 3B (PDE3B).…”

Section: Diabetic Nephropathy In Rats Induced By Hfd and Streptozotocinmentioning

confidence: 99%

Review on the Pharmacological Properties of Phillyrin

Zhou

Cheng

et al. 2022

Molecules

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Phillyrin is an effective lignan glycoside extracted from a traditional Chinese medicine Forsythia suspensa (Thunb.) Vahl (Oleaceae). It mainly exists in the roots, stems, leaves and fruits of the plant, with the highest content in the leaves. In terms of its medicinal application, there are a large number of experimental data proving its pharmacological effects in vitro and in animal models, such as anti-inflammatory, anti-obesity, anti-tumor, etc. Furthermore, pharmacokinetic experiments have also shown phillyrin’s high effectiveness and low toxicity. Despite more than one thousand studies in the literature on phillyrin retrievable from Web of Science, PubMed, and CNKI, few reviews on its pharmacological activities have been presented conclusively. In this paper, we aimed to summarize the pharmacological and pharmacokinetic characteristics of phillyrin from the current literature, focusing on its anti-inflammatory, anti-aging, antiviral, antibacterial, hepatoprotective and anti-cancer effects, hoping to come up with new insights for its application as well as future studies.

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Phillyrin lowers body weight in obese mice via the modulation of PPAR<beta>/<delta>-ANGPTL 4 pathway

Cited by 11 publications

References 30 publications

Forsythiae Fructus: A Review on its Phytochemistry, Quality Control, Pharmacology and Pharmacokinetics

Forsythiae Fructus: A Review on its Phytochemistry, Quality Control, Pharmacology and Pharmacokinetics

Phillyrin ameliorates diabetic nephropathy through the PI3K/Akt/GSK-3β signalling pathway in streptozotocin-induced diabetic mice

Review on the Pharmacological Properties of Phillyrin

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