"Phisohex" and Safer Surgery

Smylie, H. G.; Webster, Charles; Bruce, Marion L.

doi:10.1136/bmj.2.5152.606

Cited by 28 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…. ', 'this slow degerming is attributed to a film of the agent left on the hands after washing with hexachlorophane', 'it is necessary to use hexachlorophane preparations exclusively and frequently', Smylie, Webster, and Bruce in 1959 confirmed the findings of Hufnagel et al…”

supporting

confidence: 61%

Comparative antibacterial activity of hexachlorophane in different formulations used for skin disinfection

Gibson¹

1969

J Clin Pathol

View full text Add to dashboard Cite

SYNOPSIS Two formulations of hexachlorophane have been compared for their antibacterial effects in respect of skin disinfection. It was found that the activity of hexachlorophane is dependent upon its vehicle of formulation. A 2-5% soap gel possesses broad-spectrum bactericidal activity with remarkable speed of kill, whereas a 3 % detergent formulation has no bactericidal action against Gram-negative bacteria and only a very slow action against Gram-positive bacteria.In practice the rapid action of the 2-5 % soap gel against both Gram-negative and Gram-positive transient skin bacteria can be achieved by correctly applying the preparation directly to the dry hands.It appears that the 2.5 % soap gel does not need to rely on mechanical removal of transient organisms as does the 3 % detergent.The 2-5 % soap gel is more dependable in its action on the resident bacteria than the 3 % detergent. It controlled the resident flora in the skin of all subjects tested whereas the latter appeared to be potentiated on the skin of certain individuals only.It has been possible to distinguish between the antibacterial effect on the resident organisms and the mere removal of transient bacteria by mechanical action of the 3 % detergent as opposed to antibacterial effect on residents and rapid antibacterial effect on transients by the 2-5o% soap gel.Many publications in Britain and the United States have described the value of hexachlorophane preparations as skin degerming agents. Various methods have been employed to determine the reduction of organisms, but not all distinguished between antibacterial action and mechanical removal due to the detergency of the preparation. Further, little work has been published on the reasons for using particular vehicles to carry the hexachlorophane. Hufnagel, Walter, and Howard (1948)

show abstract

supporting

confidence: 61%

Comparative antibacterial activity of hexachlorophane in different formulations used for skin disinfection

Gibson¹

1969

J Clin Pathol

View full text Add to dashboard Cite

show abstract

“…When using alcoholic chlorhexidine the plates were supplemented with 1 % Tween 80 as a chlorhexidine neutralizer (12). This has been found to inhibit the carry-over effect of chlorhexidine (8).…”

Section: Methodsmentioning

confidence: 99%

Soap pH and the effectiveness of alcoholic hand antiseptics

Myklebust

1989

European J Oral Sciences

View full text Add to dashboard Cite

Abstract— This study was done to investigate if the pH‐value of a soap used for handwashing had any effect on the immediate and the prolonged effectiveness of alcoholic hand disinfectants. One acidic soap (pH = 3.5) and one alkaline soap (pH = 8.5) were tested in combination with 70% and 90% ethanol and alcoholic chlorhexidine. Bacterial counts from the hands of 26 test persons were obtained using the fingerprint method. The fingerprints were taken before and after handwashing, after hand disinfection and after 3 h of wearing sterile latex gloves. The results showed that soap pH did not influence significantly the effectiveness of a subsequent hand disinfection. The combined use of alkaline soap and alcoholic chlorhexidine showed a tendency to smaller variation in bacterial reduction and greater effectiveness. This combination was the only one that led to an increased bacterial reduction after 3 h.

show abstract

“…Contamination of the operators' hands From previous experience (Smylie, Webster and Bruce, 1959;Smylie, Logie and Smith, 1973) it was considered important to assess the bacteriological state of the outside of surgical gloves after wound closure and before removal. Plate-streak sampling was therefore carried out on members of the team firstly on their gloved hands as a test of intra-operative contamination and again after glove removal to assess residual disinfection of skin.…”

Section: The Operating Teammentioning

confidence: 99%

A study of the wound environment during total hip arthroplasty

McLauchlan

Smylie

Logie

et al. 1976

Postgraduate Medical Journal

Self Cite

View full text Add to dashboard Cite

Two hundred and seventeen total hip replacements were performed during a trial designed to assess the influence of a surgical isolator upon postoperative wound infection. The trial was controlled by performing 108 of the replacements in a standard plenum-ventilated theatre with twenty air changes/hr, which also housed the isolator procedures. Comparative postoperative wound infection rates were 6·4% for the isolator patients and 4·6% for those operated on in the plenum-ventilated theatre. There was intraoperative wound contamination in both groups of patients and, although the isolator reduced wound contamination at operation, this bore no relationship to eventual wound sepsis.

show abstract

"Phisohex" and Safer Surgery

Cited by 28 publications

References 5 publications

Comparative antibacterial activity of hexachlorophane in different formulations used for skin disinfection

Comparative antibacterial activity of hexachlorophane in different formulations used for skin disinfection

Soap pH and the effectiveness of alcoholic hand antiseptics

A study of the wound environment during total hip arthroplasty

Contact Info

Product

Resources

About