pHLA3D: An online database of predicted three-dimensional structures of HLA molecules

Characterization of the novel HLA‐DRB1*08:97 allele by next‐generation sequencing

“…Based on the HLA‐DRB1*08:02 structure available on pHLA3D website, 2 Arginine 133 is located far from the peptide groove and seems readily accessible for recognition by antibodies. Indeed, despite the fact that this amino acid does not belong to any known eplet of HLA‐DRB1 molecule, 3 this position displays a high ElliPro score (0.677) and is predicted to take part to a linear epitope (PDB file analyzed: 6CPN‐B) 4 .…”

Characterization of the novel HLA‐DRB1*01:106 allele by next‐generation sequencing

“…Based on the HLA‐DRB1*01:01 structure available on pHLA3D website, 2 Threonine 90 is not located close to the peptide groove and seems not accessible for recognition by antibodies—this amino acid does not belong to any known eplet of HLA‐DRB1 molecule 3 . However this substitution may generate new T‐cell epitopes.…”

Characterization of the novel HLA‐B*44:452 allele by next‐generation sequencing

“…Based on the HLA‐B*44:02 structure available on pHLA3D website, 2 Valine 152 is located in the peptide groove. Despite this critical position in the alpha helix of the α2 domain, the MHCcluster analysis 3 revealed that this substitution does not alter the binding repertoire compared to HLA‐B*44:02.…”