pHLA3D: Updating the database of predicted three-dimensional structures of HLA with HLA-DR, HLA-DQ and HLA-DP molecules

Oliveira, Deylane Menezes Teles e; Marroquim, Mário Sérgio Coelho; Brandão, Rafael Melo Santos de Serpa; Sousa, Luiz Cláudio Demes da Mata; Lima, Francisco das Chagas Alves; Monte, Semíramis Jamil Hadad do; Lima, Antonio Vanildo de Sousa; Coelho, Antônio Gilberto Borges; Costa, Jhonatan Matheus Sousa; Ramos, Ricardo; Pereira, Ester Miranda; Silva, Adalberto Socorro da

doi:10.1016/j.humimm.2020.10.007

Cited by 43 publications

(21 citation statements)

References 22 publications

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“…Indeed, the IPD-IMGT/HLA Database 3.44 release describes no other HLA-A allele displaying a GCC sequence in codon 271, explaining why the manufacturer did not include probes targeting this codon. The analysis of the localization of this amino-acid and its antibody accessibility with the pHLA3D database 4 indicated that this amino-acid is located out of the peptide binding groove while it is surface accessible. Threonine and Alanine are amino-acids displaying different physico-chemical properties, a transplanted organ from a donor expressing the HLA-A*01:367 allele could lead to a humoral allo-sensitization which cannot be detected by current solid-phase assays.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the novel HLA‐A01:367* allele by sequencing‐based typing

Cargou

Elsermans²,

Top³

et al. 2021

HLA

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Section: Introductionmentioning

confidence: 99%

Characterization of the novel HLA‐A01:367* allele by sequencing‐based typing

Cargou

Elsermans²,

Top³

et al. 2021

HLA

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show abstract

“…Indeed the IPD-IMGT/HLA Database 3.44.0 release describe no other HLA-DPA1 allele displaying a ATA sequence in codon 13, explaining why the manufacturer did not include probes targeting this codon. The analysis of the localization of this amino-acid and its antibody accessibility with the pHLA3D database 4 indicated that this aminoacid is located out of the peptide binding groove while its surface accessibility is unclear. Therefore, its clinical significance is unclear.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the novel HLA‐DPA101:57* allele by sequencing‐based typing

Cargou

Andreani

Giustiniani

et al. 2021

HLA

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“…Indeed the IPD-IMGT/HLA Database 3.43.0 release shows that there is no other HLA-DQA1 allele displaying an AGG sequence in codon 46, explaining why the manufacturer did not include probes recognizing this allele. The analysis of the localization of this aminoacid and its antibody accessibility with the pHLA3D database 4 indicated that this amino-acid is potentially surface accessible and located close to the peptide binding groove. Then it could have an importance in both solid organ transplantation and allogeneic hematopoietic stem cell transplantation.…”

Section: Introductionmentioning

confidence: 99%