Phlebosclerotic colitis that was difficult to distinguish from collagenous colitis

Abstract

Phlebosclerotic colitis is a rare and recently known disease entity and its etiology is still to be elucidated. Some phlebosclerotic colitis cases are difficult to distinguish from collagenous colitis because of the similarity of pathological findings. In all Japanese case reports of phlebosclerotic colitis in which an association with the use of Chinese herbal medicine is suspected, sansisi (gardenia fruit) was included, suggesting pathogenesis of this disease. We report a case of phlebosclerotic colitis that wasdifficult to be distinguished from collagenous colitis, and an association with the use of Chinese herbal medicine was suspected as the cause of the disease.

Clinical Search for Undiagnosed Mesenteric Phlebosclerosis at Outpatient Departments Specializing in Herbal (Kampo) Medicine

“…In advanced MP cases, abdominal X-rays and abdominal plain CT scans demonstrate spotted or linear calcification around (3,9). We often cannot detect calcification at during the early stageby X-ray examination (10).…”

“…Calcification of the right hemicolon and the circumferential tissue characterize MP in its advanced stages. The bronze coloration of the colonic membrane is a hallmark for the diagnosis of MP (3,9).…”

Phlebosclerotic Colitis in a Healthy Young Woman

“…PC is found in the appendix or ascending colon by accident during colonoscopy, and appears as thread-like calcifications on plain abdominal radiography and venous congestion and hyperplasia in the colon wall, calcification in the colon wall, and mesenteric veins on abdominopelvic CT scans. 1 4 5 6 7 10 11 12 13 14 15 16 17 …”

“…Colonoscopy often reveals bluish violet or dark-brownish mucosa invading the colon, cylindrical ulcers, and loss of the fissures of the semilunar colon fold. 4 5 6 7 11 12 13 14 In the tissues obtained during surgery, findings of colonic hyperplasia accompanying sclerosis and edema, and loss of the fissures on the semilunar colon fold are observable. Microscopic findings often include mucosal and submucosal necrosis, submucosal blood vessel calcification, and sclerosis.…”

Mesenteric phlebosclerosis causing a polypoid lesion mimicking colorectal carcinoma

“…Mesenteric phlebosclerosis (MP) is a rare disease characterized by ischemia of the colon caused by calcification of the peripheral mesenteric veins and thickening of the colonic wall and is strongly associated with the use of Chinese herbal medicine . To our knowledge, there are no reports of polypoid lesions as an endoscopic finding of MP . A 68‐year‐old man was referred to us because of a positive fecal occult blood test.…”