Phlebothrombosis as a Complication of Barbiturate-Induced Coma for Neuroresuscitation

factors include abnormal esophageal anatomy and/or motility, the size of the tablet or capsule, the pH of the drug in solution, and the intrinsic irritability of the drug. It is noteworthy that doxycycline capsules are fairly large and that the pH of a I percent solution of doxycycline ranges from 2.7-3.0.'·3 Clinical pharmacists, dispensing pharmacists, and physicians should be aware of the problems associated with these drugs and the potential problems that may exist with any solid oral dosage form. When dispensing oral tetracyclines, pharmacists should advise patients to take their medication with an adequate quantity of water and not to take it within one hour of retiring.

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“…We have previously reported two cases of thrombophlebosis in patients receiving high-dose barbiturates. 4 We would like to report a third case.…”

Section: Thrombophlebosis Due To High-dose Barbituratesmentioning

confidence: 95%

“…Although serum osmolality was not obtained in this patient, in our previous report they were within normal limits. 4 The intravenous use of barbiturates is not uncommon. It appears that a slow infusion of a dilute barbiturate solution is necessary to prevent this concentration-dependent phenomenon.…”

mentioning

confidence: 99%

Thrombophlebosis Due to High-Dose Barbiturates

DeNicola

Hays

1982

Drug Intelligence & Clinical Pharmacy

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Pharmacologic Management of Acute Intracranial Hypertension

Quandt¹,

Reyes²

1984

Drug Intelligence & Clinical Pharmacy

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Acute intracranial hypertension requires aggressive treatment with physiologic and pharmacologic measures guided by intracranial pressure monitoring devices. Therapy involves the use of diuretics, corticosteroids, and barbiturates in combination with hyperventilation, ventricular drainage, and general supportive measures. This review focuses on the pathophysiology of increased intracranial pressure and the pharmacologic agents used in its management.

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Phlebothrombosis as a Complication of Barbiturate-Induced Coma for Neuroresuscitation

Cited by 2 publications

References 13 publications

Thrombophlebosis Due to High-Dose Barbiturates

Thrombophlebosis Due to High-Dose Barbiturates

Pharmacologic Management of Acute Intracranial Hypertension

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