Phlolosides A–F, iridoids from Phlomis likiangensis with a carbonate ester substituent

Li, Xiaohui; Li, Xuhong; Yao, Qi; Lu, Li-He; Li, Yun-Biao; Wu, De-Song; Fu, De-Huan; Mei, Shuang-Xi; Chen, Tao; Wang, Jingkun; Zhu, Zhao-Yun

doi:10.1016/j.tetlet.2017.06.078

Cited by 12 publications

(8 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The absolute configurations of the sugar moieties in compounds 1 – 2 were determined by the method of literature reported . Compounds 1 – 2 (5.0 mg/sample) were refluxed with 10 ml of 60% aqueous dioxane with 5% HCl for 2 hr.…”

Section: Resultsmentioning

confidence: 99%

Structure elucidation and NMR assignment of two new eudesmane derivatives from Merremia yunnanensis

Yuan

et al. 2019

Magnetic Reson in Chemistry

Self Cite

View full text Add to dashboard Cite

Two new eudesmane derivatives, 1α,6β,9β‐trihydroxy‐eudesm‐3‐ene‐1‐O‐β‐d‐glucopyranoside (1) and 1α,6β,9β‐trihydroxy‐eudesm‐3‐ene‐1‐(6‐cinnamoyl)‐O‐β‐d‐glucopyranoside (2) were discovered from Merremia yunnanensis. The structures were elucidated by analysis of their spectroscopic data including HR‐ESI‐MS, 1D, and 2D NMR. It should be noted that this is the first report about structure elucidation and NMR assignment of compounds from M. yunnanensis.

show abstract

Section: Resultsmentioning

confidence: 99%

Structure elucidation and NMR assignment of two new eudesmane derivatives from Merremia yunnanensis

Yuan

et al. 2019

Magnetic Reson in Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…The absolute configurations of the sugar moieties in Compounds 1 – 3 were determined by the method of literature reported [9] . Compounds 1 – 3 (2.0 mg/sample) were refluxed with 10 mL of 60% aqueous dioxane with 5% HCl for 2 h. The reaction mixture was evaporated under vacuum and then suspended in H 2 O and extracted with CHCl 3 .…”

Section: Methodsmentioning

confidence: 99%

New dammarane-type triterpenoid saponins from Panax notoginseng saponins

Yuan

et al. 2020

Journal of Ginseng Research

Self Cite

View full text Add to dashboard Cite

Background Panax notoginseng saponin (PNS) is the extraction from the roots and rhizomes of Panax notoginseng (Burk.) F. H. Chen. PNS is the main bioactive component of Xuesaitong, Xueshuantong, and other Chinese patent medicines, which are all bestselling prescriptions in China to treat cardiocerebrovascular diseases. Notoginsenoside R 1 and ginsenoside Rg 1 , Rd, Re, and Rb 1 are the principal effective constituents of PNS, but a systematic research on the rare saponin compositions has not been conducted. Objective The objective of this study was to conduct a systematic chemical study on PNS and establish the HPLC fingerprint of PNS to provide scientific evidence in quality control. In addition, the cytotoxicity of the new compounds was tested. Methods Pure saponins from PNS were isolated by means of many chromatographic methods, and their structures were determined by extensive analyses of NMR and HR-ESI-MS studies. The fingerprint was established by HPLC-UV method. The cytotoxicity of the compounds was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5 -diphenyltetrazolium bromide assay. Results and Conclusion Three new triterpenoid saponins ( 1 – 3 ) together with 25 known rare saponins ( 4 – 28 ) were isolated from PNS, except for the five main compounds (notoginsenoside R 1 and ginsenoside Rg 1 , Rd, Re, and Rb 1 ). In addition, the HPLC fingerprint of PNS was established, and the peaks of the isolated compounds were marked. The study of chemical constituents and fingerprint was useful for the quality control of PNS. The study on antitumor activities showed that new Compound 2 exhibited significant inhibitory activity against the tested cell lines.

show abstract

“…Taxol was chosen as a positive control in this experiment, and the assay was carried out according to procedures described in the previous literature. [ 37 ]…”

Section: Methodsmentioning

confidence: 99%

Structure elucidation and NMR assignment of two new hydroxywilfordate‐type alkaloids from the stems of Tripterygium hypoglaucum and activity evaluation

Phlolosides A–F, iridoids from Phlomis likiangensis with a carbonate ester substituent

Cited by 12 publications

References 51 publications

Structure elucidation and NMR assignment of two new eudesmane derivatives from Merremia yunnanensis

Structure elucidation and NMR assignment of two new eudesmane derivatives from Merremia yunnanensis

New dammarane-type triterpenoid saponins from Panax notoginseng saponins

Structure elucidation and NMR assignment of two new hydroxywilfordate‐type alkaloids from the stems of Tripterygium hypoglaucum and activity evaluation

Contact Info

Product

Resources

About