Phloroglucinol averts isoprenaline hydrochloride induced myocardial infarction in rats

Abstract

Myocardial infarction (MI) is indicated by the symptoms like sharp chest pain, sweating, palpitations, and nervousness finally leading to heart attack. MI occurs mainly due to the risk factors like smoking, elevated blood pressure, diabetes, hypercholesterolemia, obesity, decreased HDL level, elevated LDL level, hyperlipoproteinemia and aging consequently leads to demandable coronary blood supply, oxidative stress, and acute necrosis of the myocardium. Cardioprotective potential of the phloroglucinol (PG) was assessed by treating isoprenaline hydrochloride (ISO; 85 mg/kg b.w., s.c.) induced MI model in rats. Pretreatment with PG in a dose of 30 mg/kg was done for 28 days and followed by ISO (for MI induction) on 29th and 30th days, exhibited decline in the abnormalities in the ECG patterns, cardiac marker enzymes, enzymic and nonenzymic antioxidants, lipid peroxidation, lipid profiles, and histopathological investigations compared to isoprenaline alone treated group. On the whole, the present investigations elucidate the significance of PG in alleviating the pathological process and appreciably prevent the induction of MI in experimental rats. K E Y W O R D SAST, HDL, isoprenaline, myocardial infarction, Phloroglucinol

Modulatory Effect of Cassia alata Leaf Extract on Isoproterenol-Induced Myocardial Inflammation and Fibrosis in Male Albino Wistar Rats

“…However, in pathological conditions such as MI, the formation of ROS can severely disrupt this equilibrium, increasing the load on the antioxidant defence system 30 . In this investigation, the enzymes SOD, CAT, GPx and GSH activities have significantly reduced in the heart of ISO-administered rats accommodating to the previous studies 31,32 . Increased use of these enzymes for scavenging ROS and inactivation by high ISO oxidants could explain the decline in their activity.…”

Thymoquinone attenuates isoproterenol‐induced myocardial infarction by inhibiting cytochrome C and matrix metalloproteinase‐9 expression

“…10,14 In this study, the ISP-induced MI model was used; a wellcharacterised and widely used model. 20 and decreased HDL-C, Figure 2, and Table 1. Our results are in harmony with those reported previously.…”

“…ISP was dissolved in saline. 20 Groups 5 and 6 were treated with oral doses of TQ (10 and 20 mg/kg), respectively for 8 days and subcutaneously injected with ISP (86 mg/kg) on days 5 and 6. TQ doses were chosen according to a previous study.…”

Antidepressant and Cardioprotective Effects of Self-Nanoemulsifying Self-Nanosuspension Loaded with Hypericum perforatum on Post-Myocardial Infarction Depression in Rats

“…Twenty-four hours after the last dose, all groups were subjected to behavioral assessment at 10 a.m and continued for 7 days. The ISP and HP doses were determined based on previous studies [15,26,27].…”