2013
DOI: 10.3109/09273948.2013.841484
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Phlyctenular Keratoconjunctivitis Associated withDolosigranulum pigrum

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Cited by 10 publications
(5 citation statements)
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References 18 publications
(35 reference statements)
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“…In contrast to the data mentioned above, there are very few reports of D. pigrum in association with human disease ( 60 68 ). Its frequent identification in human nasal microbiota ( 26 53 , 69 81 ) and its rare association with infection are consistent with D. pigrum functioning as a commensal and, possibly, as a mutualist of humans––characteristics that support the idea of its potential for future use as a therapeutic.…”
Section: Introductionmentioning
confidence: 72%
See 1 more Smart Citation
“…In contrast to the data mentioned above, there are very few reports of D. pigrum in association with human disease ( 60 68 ). Its frequent identification in human nasal microbiota ( 26 53 , 69 81 ) and its rare association with infection are consistent with D. pigrum functioning as a commensal and, possibly, as a mutualist of humans––characteristics that support the idea of its potential for future use as a therapeutic.…”
Section: Introductionmentioning
confidence: 72%
“…It is unclear whether these strains were contaminants or pathogenic contributors ( 60 ). However, D. pigrum strains are infrequently associated with disease ( 61 68 ). These 11 D. pigrum strains did not appear to encode potential virulence factors (see section III in Text S2 in the supplemental material), which is consistent with D. pigrum acting primarily as a mutualistic species of humans.…”
Section: Discussionmentioning
confidence: 99%
“…pigrum alone in keratitis/keratoconjunctivitis raises the possibility that some strains might be rare causes of eye surface infection (83)(84)(85)(86). We recommend future genome sequencing of ophthalmic infection isolates to ascertain whether and how these vary from currently sequenced avirulent strains.…”
Section: Discussionmentioning
confidence: 99%
“…Sherret et al [3] 61, M Sepsis OM, ESRD, CHF -Venkateswaran et al [6] 2, F Keratoconjunctivitis --Sampo et al [7] 70, M Corneal abscess --Sampo et al [7] 78, F Keratitis --Sampo et al [7] 85, M Keratitis --Sampo et al [7] 71, F Keratitis RA -Sampo et al [7] ? Conjunctivitis --Monera-Lucas et al [9] 49, F Keratitis HIV Laclaire et al [10] 43, M Eye Laclaire et al [10] ?…”
Section: Coinfecting Pathogenmentioning
confidence: 99%
“…Despite this putative role as a probiotic, with advanced microbial identification methods such as 16S rRNA and MALDI-TOF, it has increasingly been associated with disease and as such is regarded as an emerging pathogen. The preponderance of case reports documenting pathology have involved focal eye diseases such as conjunctivitis, keratitis and corneal abscess [1,[6][7][8][9][10]. The pathological spectrum extends to other critical illnesses: synovitis, sinusitis, pneumonia, cholecystitis and septicemia, however it has only rarely been associated with pre-existing immunocompromised states per se (Cystic fibrosis, HIV, Rheumatoid arthritis, Interstitial lung disease, chronic disease, extremes of age) [5,[11][12][13][14][15][16].…”
Section: Introductionmentioning
confidence: 99%