Phonophobia and brainstem excitability in migraine

Kalita, Jayantee; Bansal, Rajesh

doi:10.1111/ejn.15078

Cited by 17 publications

(11 citation statements)

References 40 publications

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“…Furthermore, in line with most of the studies quantifying auditory detection thresholds, we did not find differences between patients and controls or a correlation with phonophobia (1,2,5). Only one recent study did show clear differences in auditory detection thresholds between groups that did not correlate with the severity of phonophobia (34). We tentatively argue that it could have been affected by response biases using the MLI as especially lower thresholds were found in CM patients.…”

Section: Discussionmentioning

confidence: 99%

Avoidance behaviour modulates but does not condition phonophobia in migraine

et al. 2022

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Background Past studies do not account for avoidance behaviour in migraine as a potential confounder of phonophobia. Objective To analyse whether phonophobia is partially driven by avoidance behaviour when using the classic methodology (method of limits). Methods This is a case-control study where we tested phonophobia in a cohort of high-frequency/chronic migraine patients (15.5 ± 0.74 headache days/month) and non-headache controls. Auditory stimuli, delivered in both ears, were presented using three different paradigms: the method of limits, the method of constant stimuli, and the adaptive method. Participants were asked to report how bothersome each tone was until a sound aversion threshold was estimated for each method. Results In this study, we successfully replicate previously reported reduction in sound aversion threshold using three different methods in a group of 35 patients and 25 controls (p < 0.0001). Avoidance behaviour in migraine reduced sound aversion threshold in the method of limits (p = 0.0002) and the adaptive method (p < 0.0001) when compared to the method of constant stimuli. While thresholds in controls remained the same across methods (method of limits, p = 0.9877 and adaptive method, p = 1). Conclusion Avoidance behaviour can exacerbate phonophobia. The current methodology to measure phonophobia needs to be revised.

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Section: Discussionmentioning

confidence: 99%

Avoidance behaviour modulates but does not condition phonophobia in migraine

et al. 2022

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“…Phonophobia might be an independent symptom of MD, which was found in 84% of MD patients and was unrelated to the presence of migraine [ 27 ]; this finding is inconsistent with the results of our study. Phonophobia might be attributed to lowered hearing threshold, which results from higher brainstem auditory neurol sensitivity [ 28 ]. This mechanism may explain our finding that phonophobia was infrequent in MD patients.…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of the Predictive Model for the Differentiation between Vestibular Migraine and Meniere’s Disease

Liú

Guo

Wang

et al. 2022

JCM

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(1) Background: Vestibular migraine (VM) and Meniere’s disease (MD) share multiple features in terms of clinical presentations and auditory-vestibular dysfunctions, e.g., vertigo, hearing loss, and headache. Therefore, differentiation between VM and MD is of great significance. (2) Methods: We retrospectively analyzed the medical records of 110 patients with VM and 110 patients with MD. We at first established a regression equation by using logistic regression analysis. Furthermore, sensitivity, specificity, accuracy, positive predicted value (PV), and negative PV of screened parameters were assessed and intuitively displayed by receiver operating characteristic curve (ROC curve). Then, two visualization tools, i.e., nomograph and applet, were established for convenience of clinicians. Furthermore, other patients with VM or MD were recruited to validate the power of the equation by ROC curve and the Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva (GiViTI) calibration belt. (3) Results: The clinical manifestations and auditory-vestibular functions could help differentiate VM from MD, including attack frequency (X5), phonophobia (X13), electrocochleogram (ECochG) (X18), head-shaking test (HST) (X23), ocular vestibular evoked myogenic potential (o-VEMP) (X27), and horizontal gain of vestibular autorotation test (VAT) (X30). On the basis of statistically significant parameters screened by Chi-square test and multivariable double logistic regression analysis, we established a regression equation: P = 1/[1 + e−(−2.269× X5 − 2.395× X13 + 2.141× X18 + 3.949 × X23 + 2.798× X27 − 4.275× X30(1) − 5.811× X30(2) + 0.873)] (P, predictive value; e, natural logarithm). Nomographs and applets were used to visualize our result. After validation, the prediction model showed good discriminative power and calibrating power. (4) Conclusions: Our study suggested that a diagnostic algorithm based on available clinical features and an auditory-vestibular function regression equation is clinically effective and feasible as a differentiating tool and could improve the differential diagnosis between VM and MD.

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“…BAEP, a sensitive indicator of brainstem and auditory center injury, has wide applications in clinical diagnosis and treatment. BAEP will be altered when brain stem and auditory pathway are slightly injured, even if there are no clinical manifestations and signs [22][23][24] . In this study, it was found that the average bilirubin level in the BIND group was higher than that in the non-BIND group.…”

Section: Discussionmentioning

confidence: 99%

The Evaluation of Conventional MRI, Diffusion Tensor Imaging, and Arterial Spin Labeling Imaging for Early Brain Damage Caused by Neonatal Hyperbilirubinemia

Chang

Song

et al. 2021

Preprint

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Purpose: To evaluate the early bilirubin-induced neurologic dysfunction (BIND) by T1 weighted imaging (T1WI), diffusion tensor imaging (DTI), and arterial spin labeling (ASL).Methods: Forty newborns: hyperbilirubinemia with BIND (BIND group, n=13), hyperbilirubinemia without BIND (non-BIND group, n=17), and healthy newborns (HC group, n=10). The MRI parameters of globus pallidus were measured, including the T1WI signal values from conventional MRI, apparent diffusion coefficient (ADC), the fractional anisotropy (FA), relative anisotropy (RA) and volume ratio (VR) value from DTI, and the relative cerebral blood flow (rCBF) value from ASL. The group differences were analyzed by ANOVA with Bonferroni correction. The diagnosis efficiencies were assessed by the receiver operating characteristic curve (ROC). The correlation between those parameters and serum bilirubin level was evaluated by Pearson’s correlation coefficient.Results: 1）The mean signal values of globus pallidus on T1WI and DTI parameters were significantly different among the groups (p < 0.05). The difference in T1WI between the non-BIND group and the BIND group was not significant (p >0.05). The rCBF of globus pallidus was not significantly different among the three groups (p > 0.05). 2) The T1WI, FA, and RA values were positively while the VR value was negatively correlated with serum bilirubin level (r =0.763, 0.585, 0.586, -0.544 respectively, p < 0.05). The ADC value and rCBF were not correlated with serum bilirubin (r = -0.050, -0.275 respectively, p > 0.05). 3) The area under curve (AUC) of T1WI, FA, RA, VR was 0.953, 0.897, 0.897, 0.860 respectively. And the AUC of the diagnosis method, combined T1WI, FA, RA and VR, was 0.987.Conclusion: The index, combined T1WI and DTI parameters, was important for diagnosing early hyperbilirubinemia brain injury. ASL might not have function on diagnosing early hyperbilirubinemia brain injure.

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Phonophobia and brainstem excitability in migraine

Cited by 17 publications

References 40 publications

Avoidance behaviour modulates but does not condition phonophobia in migraine

Avoidance behaviour modulates but does not condition phonophobia in migraine

Development and Validation of the Predictive Model for the Differentiation between Vestibular Migraine and Meniere’s Disease

The Evaluation of Conventional MRI, Diffusion Tensor Imaging, and Arterial Spin Labeling Imaging for Early Brain Damage Caused by Neonatal Hyperbilirubinemia

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