Phorbol ester induces abnormal chronic lymphocytic leukemia cells to express features of hairy cell leukemia

Caligaris-Cappio, Federico; Pizzolo, Giovanni; Chilosi, Marco; Bergui, Luciana; Semenzato, G.; Tesio, L; Morittu, L.; Malavasi, Fabio; Gobbi, Marco; Schwarting, Roland

doi:10.1182/blood.v66.5.1035.1035

Cited by 56 publications

(6 citation statements)

References 33 publications

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“…Melo et al [ 11 suggested that HCL, HCL variant, SLVL, and PLL represent a spectrum of cell types frozen at slightly different stages during late B-cell maturation. In fact, these different cell types (e.g., CLL and PLL) can be induced by phorbol ester and evolve into other cell type (e.g., HCL) [22,23]. The present case suggests that evolution between SLVL and other low-grade B-cell lymphoproliferative disorders may take place as well.…”

Section: Discussionmentioning

confidence: 62%

Relationship between hairy cell leukemia variant and splenic lymphoma with villous lymphocytes: Presentation of a new concept

Sun¹,

Dittmar²,

Koduru³

et al. 1996

Am. J. Hematol.

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An unusual case of low-grade B-cell lymphoproliferative disorder with peripheral lymphocytosis and splenomegaly followed for 4 1/2 years is reported. During this period, the phenotype of the tumor cells in the blood changed from that of hairy cell leukemia (HCL)/chronic lymphocyte leukemia (CLL) to HCL/prolymphocytic leukemia (PLL), to PLL. The lymphoid population in the blood showed a mixture of hairy cells, villous lymphocytes, small lymphocytes, and prolymphocytes, corresponding to the phenotypes at various stages. Although relatively specific markers for CLL, HCL, and PLL, such as CD5, CD11c, CD22, CD25, and FMC-7, were positive at various stages, all these markers have also been demonstrated in a large study series of splenic lymphoma with villous lymphocytes (SLVL). In addition, the histologic pattern of the bone marrow biopsy and splenectomy specimen were not typical for HCL. This case can therefore be classified either as HCL variant or as SLVL. As SLVL assumes various cytologic and histologic patterns, which overlap with different lymphoproliferative disorders, especially HCL variants, this entity appears to represent a heterogeneous group of lymphomas/leukemias that may evolve into each other. The absence of activation of c-myc and bc1-2 oncogenes as well as mutation of p53 tumor suppressor gene, together with the presence of only one single rearranged band for both heavy chain and kappa light chain genes in our case suggest that these morphologically different lymphoid tumors may belong to the same family.

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Section: Discussionmentioning

confidence: 62%

Relationship between hairy cell leukemia variant and splenic lymphoma with villous lymphocytes: Presentation of a new concept

Sun¹,

Dittmar²,

Koduru³

et al. 1996

Am. J. Hematol.

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“…12 TNFbp (p55 TNF soluble receptor 13 ) and recombinant human IL-1Ra were a kind gift of Dr Carl Edwards (Amgen, Thousand Oaks, CA). The following primary antibodies were used: anti-CD14 (Pharmingen, San Diego, CA), antibodies to CD11a (L7 14 ), CD11b (Kim225 15 ), CD11c (SHCI3 16 ), CD29 (TS2/16 17 ), CD49d (HP2/1 18 ), CD49e (SAM-1 19 ), ICAM-1 (Rek-1 20 ), ICAM-2 (CBR2/2 21 ), and ALCAM (1F2 22 ). Antibodies to CD18 (AZN-L19) and ICAM-3 (AZN-IC3) were developed at the Department of Tumour Immunology, University Medical Center St. Radboud, Nijmegen, the Netherlands.…”

Section: Reagentsmentioning

confidence: 99%

Selective regulation of intercellular adhesion molecule‐1 expression by interleukin‐18 and interleukin‐12 on human monocytes

et al. 2003

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SUMMARYInduction of expression of adhesion molecules is a crucial step in in¯ammation. The role of interleukin-18 (IL-18) in induction of various adhesion molecules was investigated in freshly isolated peripheral blood mononuclear cells and human monocyte and T-cell lines. IL-18 selectively up-regulated intercellular adhesion molecule-1 (ICAM-1) expression on freshly isolated human monocytes, but not on lymphocytes. The expression of other adhesion molecules was not in¯uenced. Induction of ICAM-1 by IL-18 was dependent on endogenous tumour necrosis factor-a (TNF-a), and IL-12 had an additive effect on that of IL-18. No changes in adhesion molecule expression were observed on the monocytic cell line THP-1 and on the T-cell lines HSB-2 and Jurkat J16. In addition, induction of ICAM-1 on monocytes by lipopolysaccharide was slightly, but signi®cantly, inhibited by blockade of either endogenous IL-18 or TNF-a with IL-18 binding protein or TNF binding protein, respectively. Blocking IL-1 effects with IL-1 receptor antagonist did not in¯uence ICAM-1 levels. In conclusion, IL-18 selectively up-regulates the expression of ICAM-1 on monocytes, and this contributes to the proin¯ammatory effects of this cytokine.

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“…Cowan staphylococci have been used to induce differentiation as far as to switch immunoglobulin production from IgM to IgG in a fraction of the leukemic cell populations (39). Another interesting observation in CLL cells activated by TPA is the achievement of characteristics typical for hairy cell leukemia (35,40).…”

Section: Pat Hophysiological Considerationsmentioning

confidence: 99%

Activation of malignant B‐lymphocytes: pathophysiologic and clinical importance

Robért¹,

Juliusson²,

Einhorn

et al. 1986

Scandinavian Journal of Haematology

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Recent advances in clarifying the activation mechanisms of the normal immune system have provided the basis for successful experiments concerning the activation of malignant lymphocytes. Such studies with malignant cells, freshly sampled from patients with lymphoproliferative diseases, can be used for pathophysiological considerations, analysis of tumor evolution, classification of malignant subsets, and karyotyping. Of particular interest is the possibility of abrogating the maturation arrest in some clonally‐restricted cells. This might lead to therapeutical implications, since the differentiation blockage plays a fundamental role in the clonal expansion and pathogenesis of tumors. Recently, it has been shown that interferon (IFN) can be a potent inducer of various degrees of transformation, differentiation and even proliferation in different subsets of normal and malignant B cells. This may be important in explaining the divergent results of IFN treatment in various malignant B‐cell disorders.

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Phorbol ester induces abnormal chronic lymphocytic leukemia cells to express features of hairy cell leukemia

Cited by 56 publications

References 33 publications

Relationship between hairy cell leukemia variant and splenic lymphoma with villous lymphocytes: Presentation of a new concept

Relationship between hairy cell leukemia variant and splenic lymphoma with villous lymphocytes: Presentation of a new concept

Selective regulation of intercellular adhesion molecule‐1 expression by interleukin‐18 and interleukin‐12 on human monocytes

Activation of malignant B‐lymphocytes: pathophysiologic and clinical importance

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