1974
DOI: 10.1007/978-3-7091-7094-6_7
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Phorbolesters — the Irritants and Cocarcinogens of Croton Tiglium L.

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Cited by 122 publications
(133 citation statements)
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“…[1][2][3][4]. These compounds are, in addition, the most potent class of tumor promoters for mouse skin (5,6). This laboratory and others (7)(8)(9)(10)(11)(12)(13) have demonstrated high-affinity specific receptors for phorbol esters in membrane preparations and in intact cells with [3H]phorbol 12,13-dibutyrate (PBt2).…”
mentioning
confidence: 99%
“…[1][2][3][4]. These compounds are, in addition, the most potent class of tumor promoters for mouse skin (5,6). This laboratory and others (7)(8)(9)(10)(11)(12)(13) have demonstrated high-affinity specific receptors for phorbol esters in membrane preparations and in intact cells with [3H]phorbol 12,13-dibutyrate (PBt2).…”
mentioning
confidence: 99%
“…However, a number of Croton species are known to present carcinogenic and irritating effects due to the presence of phorbol diterpene esters among their chemical constituents (Hecker & Schmidt 1974;Weber & Hecker 1978). In previous studies (Maciel et al 1998), our group found no harmful compounds in Croton cajucara, which may explain the apparent absence of toxic effects in derivatives of this plant when used in moderation.…”
Section: Discussionmentioning
confidence: 55%
“…Our results agree with those of Agner et al (1999) who subjected mice to acute treatment with DCTN (the major ingredient of C. cajucara) and found no significant genotoxic activity for this compound. In our experiments, the absence of genotoxicity may have been due to the absence of forbol diterpene esters which are present in many toxic Croton species and are known to cause various toxic effects and to be carcinogenic (Hecker and Schmidt, 1974;Weber and Hecker, 1978).…”
Section: Discussionmentioning
confidence: 62%