2003
DOI: 10.1016/s0014-4886(03)00090-6
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Phosphacan and neurocan are repulsive substrata for adhesion and neurite extension of adult rat dorsal root ganglion neurons in vitro

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Cited by 50 publications
(43 citation statements)
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“…Neurocan is normally expressed in embryonic neural stem cells, but its expression decreases rapidly after birth in wild type mice (Sango et al, 2003;Ida et al, 2006). In contrast, neurocan was expressed at P10 around cortical blood vessels in the mutant mice (data not shown) and was strongly upregulated in the MZ and the Cg and RSG cortices along the fissura longitudinalis cerebri in the mutant mice at 10 month (Fig.…”
Section: Glial Bmpria Plays a Critical Role In Formation Of The Bbbmentioning
confidence: 89%
See 1 more Smart Citation
“…Neurocan is normally expressed in embryonic neural stem cells, but its expression decreases rapidly after birth in wild type mice (Sango et al, 2003;Ida et al, 2006). In contrast, neurocan was expressed at P10 around cortical blood vessels in the mutant mice (data not shown) and was strongly upregulated in the MZ and the Cg and RSG cortices along the fissura longitudinalis cerebri in the mutant mice at 10 month (Fig.…”
Section: Glial Bmpria Plays a Critical Role In Formation Of The Bbbmentioning
confidence: 89%
“…When Bmpr1a was knocked down by siRNA in primary cultured astrocytes, expressions of collagens, which play an important role in adhesion between astrocytes and ECs, were significantly down regulated (Sango et al, 2003;Brightman, 2002). It is reported that intracellular SMAD signaling induces expression of extracellular matrix (ECM) and basement membrane components in cultured astrocytes via Type IV pro-collagens (Fuchshofer et al, 2005;Gaussin, 2002;Jackson et al, 2003).…”
Section: Discussionmentioning
confidence: 99%
“…After rinsing in PBS for 15 min, the sections were incubated at 37 ° C for 1 h with biotin-conjugated anti-mouse IgM (Vector Laboratories Inc., Burlingame, Calif., USA), followed by reaction with avidin and biotinylated horseradish peroxidase complex (ABC Elite kit, Vector Laboratories) at room temperature for 30 min. After rinsing in PBS for 15 min, the immunoreaction was visualized under a light microscope using 0.01% diaminobenzidine tetrahydrochloride (Wako Co., Tokyo, Japan) and 0.01% hydrogen peroxide in 50 m M Tris buffer (pH 7.4) at 37 ° C for 15 min [19] . Sections were counterstained with hematoxylin.…”
Section: Immunohistochemistrymentioning
confidence: 99%
“…These findings suggest that these neovessels had little, if any, perivascular innervation. The main reason for the lack of a nervous system in neovessels may be that the cornea contains inhibitory substances, such as semaphorin 3A and proteoglycan chondroitin sulfate, 14) which prevent the distribution of perivascular nerves. [15][16][17] It is suggested that bFGF increases semaphorin 3A expression to inhibit perivascular innervation, as reported by a study that expression of semaphorin 3A in corneal fibroblasts is regulated by epidermal growth factor released from corneal epithelial cells.…”
Section: Discussionmentioning
confidence: 99%