Phosphanegold(I) dithiocarbamates, R3PAu[SC(S)N(iPr)CH2CH2OH] for R = Ph, Cy and Et: Role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways

In vitro antibacterial and time-kill evaluation of phosphanegold(I) dithiocarbamates, R3PAu[S2CN(iPr)CH2CH2OH] for R = Ph, Cy and Et, against a broad range of Gram-positive and Gram-negative bacteria

“…Crystal structure analysis on 3 and 4 [19] proved linear PAu-S coordination geometries with the second sulphur atom oriented towards gold as indicated in Fig. 1.…”

“…apoptopic for 2 and Relative to log 10 cfu/ml of initial inoculum (a negative value indicates a reduction of bacterial cell number), values shown are the means of triplicate determinations from each experiment, ND not determined, as either the bacteria had been killed at a specific time or there was no obvious reduction of cell growth necrotic for 3 and 4 [19]; the salt was non-cytotoxic. The motivation for the present study arose from recent observations of remarkable antimicrobial activities, specifically against Gram-positive bacteria, exhibited by related phosphanegold(I) thiocarbamate compounds, i.e.…”

“…The R 3 PAu[S 2 CN(iPr)CH 2 CH 2 OH] compounds, where R = Ph (2), Cy (3) and Et (4), were prepared from the reaction of t h e r e s p e c t i v e R 3 PA u C l p r e c u r s o r w i t h t h e Na[S 2 CN(iPr)CH 2 CH 2 OH] salt as described in the literature [19]. The compounds exhibited the reported spectroscopic attributes (IR, 1 H and 13 C{1H} NMR).…”

“…1, i.e. phosphanegold(I) dithiocarbamates, several studies focussing on cytotoxicity profiles and mechanisms of cell death have appeared [17][18][19]. Even more studies of gold(III) dithiocarbamates are available as these potent compounds exhibit in vivo potential, have limited nephrotoxicity and a different mechanism of action to the widely used anti-cancer drug cisplatin, (NH 3 ) 2 PtCl 2 [20][21][22][23][24].…”

Reactivity of Mononuclear and Dinuclear Gold(I) Amidinate Complexes with CS2 and CsBr3

“…Over time, aurophilic interactions, which have comparable strength to a hydrogen bond, start to form which could account for the solubility issues and precipitation from solution. The stacking of discrete dimeric units in the solid-state is not new in gold dithiocarbamate chemistry [28,[31][32][33][34][35]. yield.…”