Phosphatase and Tensin Homologue Genetic Polymorphisms and their Interactions with Viral Mutations on the Risk of Hepatocellular Carcinoma

Du, Yan; Zhang, Yu-Wei; Pu, Rui; Han, Xue; Hu, Jianping; Zhang, Hongwei; Wang, Hongyang; Cao, Guangwen

doi:10.4103/0366-6999.155057

Cited by 6 publications

(7 citation statements)

References 35 publications

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“…PTEN gene includes a 32-bp deletion polymorphism (rs34421660) mapped on intron 2, but its function in human diseases is still unclear. A few studies have examined the correlation between the PTEN 32-bp deletion variant and liver-related diseases [3,10]. Ding et al [9] evaluated the association between this genetic variation and the risk for HCC in a Chinese population [9].…”

Section: Introductionmentioning

confidence: 99%

Lack of relationship between PTEN 32-bp and TP53 16-bp Ins/Del polymorphisms and chronic hepatitis B virus infection

Eskandari

Dahmardeh

et al. 2017

VirusDis.

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TP53 and phosphate and tension homolog (PTEN) are two tumor suppressor genes that regulate cell proliferation, migration, and death. P53 and PTEN deficiency has been associated with hepatic fibrosis, a prominent pathological feature associated with chronic hepatitis B (CHB). The present study is aimed to assess the association of PTEN 32-bp Ins/Del (rs34421660) and TP53 16-bp Ins/Del polymorphisms with CHB infection susceptibility. A total of 411 subjects were recruited in this case-control study of 213 patients with CHB infection and 198 healthy individuals as controls. PTEN and TP53 deletions were detected by polymerase chain reaction method. We found no significant association between PTEN 32-bp Ins/Del polymorphism and the risk for CHB using either of codominant (Ins/Del vs. Ins/Ins: = 0.427; Del/Del vs. Ins/Ins: = 0.235), dominant (Ins/Del + Del/Del vs. Ins/Ins = 0.343) or recessive genetic model (Del/Del vs. Ins/Ins + Ins/Del: = 0.516). At allelic level although the PTEN Del variant allele was more common in CHB patients compared to controls (55 vs. 51), but the difference did not reach the statistical significant range (OR 0.87, = 0.327). Similarly, no association was observed between TP53 16-bp Ins/Del and the risk for CHB infection at both genotype and allele levels ( > 0.05). In summary, our study demonstrated that the PTEN 32-bp and TP53 16-bp Ins/Del polymorphisms did not affect the risk of CHB infection in the Iranian population.

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Section: Introductionmentioning

confidence: 99%

Lack of relationship between PTEN 32-bp and TP53 16-bp Ins/Del polymorphisms and chronic hepatitis B virus infection

Eskandari

Dahmardeh

et al. 2017

VirusDis.

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“…Previous studies have shown that the CA genotype of rs2299939 could reduce the risk of hepatocellular carcinoma. It revealed the association of PTEN gene polymorphisms with liver cancer risk (Du et al, 2015;Li et al, 2015). Our group previously found that the PTEN gene CC genotype of rs2299939 was sensitive to radiotherapy in adenocarcinoma and squamous cell carcinoma (Wang et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy

et al. 2020

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Lung cancer has higher morbidity and mortality than most cancers. It is common that there are some phenomenons of secondary drug resistance, radiotherapy resistance and poor prognosis during the treatment of small cell lung cancer (SCLC). Recent studies revealed that the single-nucleotide polymorphisms (SNPs) are associated with the curative effect among patients with the same pathological type and stage. Our study analyzed the start time of radiotherapy and the relationship between PTEN gene rs2299939 polymorphisms and survival time among 116 SCLC patients. The results showed that early radiotherapy significantly improved the time of survival in patients compared with late radiotherapy (P = 0.029). Simultaneously, the study found that patients with the rs2299939 AA genotype showed significant sensitivity to both early and late radiotherapy, but early radiotherapy is better. The median survival time of CC genotype patients was 12 months in the early radiotherapy group while it was 9 months in the late radiotherapy group, thus recommending early radiotherapy among these patients. In addition, it was found that rs2299939 could regulate the expression of related genes in peripheral blood and lung tissues by eQTL analysis. This study revealed that the early radiotherapy could prolong the PFS of SCLC and shall be performed in SCLC treatment.

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“…Research suggests that PTEN has a variety of biological functions, for instance inhibiting angiogenesis, regulating cell proliferation, differentiation, and apoptosis. Thus, several studies have revealed a correlation between PTEN gene polymorphisms and various types of cancers, such as hepatocellular carcinoma, chronic myeloid leukemia (CML), and breast cancer 5‐7 . To date, three studies have found that PTEN gene polymorphisms were associated with the overall survival and sensitivity to chemoradiotherapy of NSCLC 8‐10 .…”

Section: Introductionmentioning

confidence: 99%

“…as hepatocellular carcinoma, chronic myeloid leukemia (CML), and breast cancer. [5][6][7] To date, three studies have found that PTEN gene polymorphisms were associated with the overall survival and sensitivity to chemoradiotherapy of NSCLC. [8][9][10] Nevertheless, there are few studies concerning the linkage between PTEN SNPs and susceptibility to NSCLC.…”

Section: Introductionmentioning

confidence: 99%

Association of phosphatase and tension homologue deleted on chromosome ten polymorphism rs1903858, but not serum levels with the risk of non–small‐cell lung cancer: A case‐control study

Liang¹,

Tang

et al. 2020

Clinical Laboratory Analysis

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Background To investigate the association between phosphatase and tension homologue deleted on chromosome ten ( PTEN ) gene polymorphisms and non–small‐cell lung cancer (NSCLC) and further identify whether these polymorphisms influence serum PTEN levels. Methods A total of 152 NSCLC patients and 124 healthy controls were included in the study. PTEN gene rs11202586 (T > C) and rs1903858 (A > G) polymorphisms were detected using the multiple single‐base extension technique (SNaPshot). The serum PTEN levels were determined using an enzyme‐linked immunosorbent assay (ELISA) kit. Results The rs1903858 AG, GG genotypes, and G allele were associated with a higher risk of NSCLC (odds ratio (OR) =2.079, 95% confidence interval (CI) = 1.087‐3.974, P = .027; OR = 1.897, 95%CI = 1.053‐3.419, P = .033; OR = 1.505, 95%CI = 1.065‐2.126, P = .020). Stratified analysis reveal that the rs1903858 GG genotype and G allele were associated with an increased risk of squamous cell carcinoma (SCC) (OR = 3.226, 95%CI = 1.075‐9.678, P = .037; OR = 1.873, 95%CI = 1.092‐3.212, P = .023). Among smokers, the rs1903858 G allele carriers have an increased risk of NSCLC (OR = 1.916, 95%CI = 1.023‐3.589, P = .042), but a decreased risk of NSCLC was found with the AT haplotype. With respect to the serum PTEN levels, no significant difference was noted between NSCLC patients and healthy controls in this study. Conclusions The study indicated that the rs1903858 gene polymorphism is associated with increased risk of NSCLC, particularly in SCC and smoker, and the haplotype AT was a protective factor for NSCLC. The serum PTEN levels were not associated with NSCLC.

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Phosphatase and Tensin Homologue Genetic Polymorphisms and their Interactions with Viral Mutations on the Risk of Hepatocellular Carcinoma

Cited by 6 publications

References 35 publications

Lack of relationship between PTEN 32-bp and TP53 16-bp Ins/Del polymorphisms and chronic hepatitis B virus infection

Lack of relationship between PTEN 32-bp and TP53 16-bp Ins/Del polymorphisms and chronic hepatitis B virus infection

Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy

Association of phosphatase and tension homologue deleted on chromosome ten polymorphism rs1903858, but not serum levels with the risk of non–small‐cell lung cancer: A case‐control study

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