Phosphate group effects upon the equilibrium of iron(III) meso-tetrakis (4-N-methylpyridiniumyl) porphyrin in aqueous solution

Santiago, Patrícia S.; Moreira, Leonardo Marmo; Tabak, Marcel

doi:10.1016/j.jinorgbio.2006.03.018

Cited by 3 publications

(4 citation statements)

References 33 publications

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“…[41] Furthermore, in biological medium, metalloporphyrins can be coordinated by several biological molecules that can act as ligands, such as phosphate. [129] This is an interesting point because several metalloporphyrins, such as Sn(iv)TMPyP, do not aggregate, probably because of two axial ligands, and preserve their photosensitizing ability. [130] Therefore, the location of porphyrin photosensitizers in a biological membrane depends strongly on their peripheral substituent groups as well as their axial ligands, which determine solubility, chemical affinity, redox potential, and other properties of these macrocycles.…”

Section: Porphyrins and Metalloporphyrinsmentioning

confidence: 99%

Photodynamic Therapy: Porphyrins and Phthalocyanines as Photosensitizers

et al. 2008

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The present work is focussed on the principles of photodynamic therapy (PDT), emphasizing the photochemical mechanisms of reactive oxygen species formation and the consequent biochemical processes generated by the action of reactive oxygen species on various biological macromolecules and organelles. This paper also presents some of the most used photosensitizers, including Photofrin, and the new prototypes of photosensitizers, analysing their physicochemical and spectroscopic properties. At this point, the review discusses the therapeutic window of absorption of specific wavelengths involving first-and second-generation photosensitizers, as well as the principal light sources used in PDT. Additionally, the aggregation process, which consists in a phenomenon common to several photosensitizers, is studied. J-aggregates and H-aggregates are discussed, along with their spectroscopic effects. Most photosensitizers have a significant hydrophobic character; thus, the study of the types of aggregation in aqueous solvent is very relevant. Important aspects of the coordination chemistry of metalloporphyrins and metallophthalocyanines used as photosensitizers are also discussed. The state-of-the-art in PDT is evaluated, discussing recent articles in this area. Furthermore, macrocyclic photosensitizers, such as porphyrins and phthalocyanines, are specifically described. The present review is an important contribution, because PDT is one of the most auspicious advances in the therapy against cancer and other non-malignant diseases.

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Section: Porphyrins and Metalloporphyrinsmentioning

confidence: 99%

Photodynamic Therapy: Porphyrins and Phthalocyanines as Photosensitizers

et al. 2008

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“…Figure displays the spectra of clean GaOOH by itself as well as the in situ and ex situ GaOOH/TTP‐PO 3 . The stretch found near approximately 1650 cm −1 can be attributed to the presence of CN bond stretching in the pyrolle ring of TTP‐PO 3 (Santiago et al, ). The bands near 1030 and 950 cm −1 were found in each sample and can be attributed to typical bands found in GaOOH (Quan et al, ).…”

Section: Resultsmentioning

confidence: 99%

In situ and ex situ functionalization of nanostructured gallium oxy‐hydroxide with a porphyrin dye

Pearce¹,

Berg²,

Rahn³

et al. 2016

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The surface attachment of a porphyrin dye to nanocrystalline GaOOH was performed using two routes of solution-based functionalization. The first method of functionalization utilized an in situ incorporation of dissolved porphyrin salt in solution during the microwave synthesis step. Additionally, synthesized GaOOH nanorods were mixed in porphyrin solution after the microwave process to make an ex situ GaOOH/TTP-PO- . X-ray photoelectron spectroscopy confirmed the presence of expected surface species and provided evidence of increased surface coverage of TTP-PO on GaOOH in the ex situ- GaOOH/TTP-PO as compared to the in situ one. Size and morphology changes were investigated using SEM and, along with analysis of XRD, the in situ samples showed larger crystallite sizes. This was confirmed with PL due to the higher bandgap energy evident in the ex situ GaOOH/TTP-PO compared to the in situ sample. A stability study was performed using fluorescence spectroscopy which indicated no leaching of porphyrin from the in situ GaOOH/TTP-PO . However, porphyrin leaching was evident from the ex situ GaOOH/TTP-PO sample. The stability of the in situ GaOOH/TTP-PO makes it attractive for a number of interfacial applications. SCANNING 38:671-683, 2016. © 2016 Wiley Periodicals, Inc.

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“…Santiago et al gathered FTIR data between 1800 and 400 cm À1 for an iron porphyrin under various pH conditions. 46 The peak near 1000 cm À1 was attributed to the stretching mode, the P-O bond. A peak present near 1650 cm À1 was attributed to the stretching modes of the bond between the ring structure carbons and nitrogen within the porphyrin.…”

Section: Infrared Spectroscopymentioning

confidence: 99%

“…28 Additionally, a peak present near 1450 cm À1 , attributed to the stretching of the C-N bond within the porphyrin ring, as well as a strong peak 45 near 1650 cm À1 for C5N stretching mode within the porphyrin ring were recorded. 46 3. Stability testing using fluorescence spectroscopy By utilizing a porphyrin adsorbate, the naturally strong fluorescent signal can be used to confirm successful functionalization both presoaking and postsoaking following the in situ procedure.…”

Section: Infrared Spectroscopymentioning

confidence: 99%

In situ functionalization of gallium nitride powder with a porphyrin dye

et al. 2015

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This work focused on the modification of milled GaN powder. Successful attachment of a porphyrin derivative to a GaN powder was performed via in situ functionalization in the presence of phosphoric acid. The GaN powder was imaged using scanning electron microscopy and was found to be heterogeneous in nature, adopting no consistent geometry in the aggregates. The aqueous stability of the porphyrin used was observed in deionized water and a solution of phosphoric acid using ultraviolet-visible spectroscopy. Surface chemistry was characterized with x-ray photoelectron spectroscopy and infrared spectroscopy, which identified evidence of successful functionalization through the presence of characteristic peaks. The interface stability of the covalent bond between GaN and porphyrin was evaluated using fluorescence spectroscopy and demonstrated no leaching of dye in water solutions for 20 days.

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Phosphate group effects upon the equilibrium of iron(III) meso-tetrakis (4-N-methylpyridiniumyl) porphyrin in aqueous solution

Cited by 3 publications

References 33 publications

Photodynamic Therapy: Porphyrins and Phthalocyanines as Photosensitizers

Photodynamic Therapy: Porphyrins and Phthalocyanines as Photosensitizers

In situ and ex situ functionalization of nanostructured gallium oxy‐hydroxide with a porphyrin dye

In situ functionalization of gallium nitride powder with a porphyrin dye

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