Phosphate-independent utilization of phosphonoacetic acid as sole phosphorus source by a psychrophilic strain of Geomyces pannorum P15

Klimek‐Ochab, Magdalena

doi:10.1007/s12223-014-0309-3

Cited by 4 publications

(2 citation statements)

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“…Phosphonoacetic acid was used as an Phenyphosphonic and phenylphosphinic acids were used for obtaining complexes [14], such as organic-inorganic hybrid materials obtained by the coordination of phosphonic (inic) ligands to metal ions, to obtain polymeric-related structures characterized by different dimensionalities [15] or as flame retardants [16,17]. Phosphonoacetic acid was used as an inhibitor of herpes simplex virus, [18], as a phosphorus source for microbial growth in a phosphate-independent manner [19] and also for obtaining heterobimetalic metal phosphonates [20]. 2-carboxyethylphenylphosphinic acid is one of the most promising reagents for obtaining metal-organic frameworks [21] or flame retardants for polymers [22].…”

Section: Introductionmentioning

confidence: 99%

The Biological Impact of Some Phosphonic and Phosphinic Acid Derivatives on Human Osteosarcoma

Khaled,

Ilia,

Watz

et al. 2024

CIMB

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Osteosarcoma malignancy currently represents a major health problem; therefore, the need for new therapy approaches is of great interest. In this regard, the current study aims to evaluate the anti-neoplastic potential of a newly developed phosphinic acid derivative (2-carboxyethylphenylphosphinic acid) and, subsequently, to outline its pharmaco-toxicological profile by employing two different in vitro human cell cultures (keratinocytes—HaCaT—and osteosarcoma SAOS-2 cells), employing different techniques (MTT assay, cell morphology assessment, LDH assay, Hoechst staining and RT-PCR). Additionally, the results obtained are compared with three commercially available phosphorus-containing compounds (P1, P2, P3). The results recorded for the newly developed compound (P4) revealed good biocompatibility (cell viability of 77%) when concentrations up to 5 mM were used on HaCaT cells for 24 h. Also, the HaCaT cultures showed no significant morphological alterations or gene modulation, thus achieving a biosafety profile even superior to some of the commercial products tested herein. Moreover, in terms of anti-osteosarcoma activity, 2-carboxyethylphenylphosphinic acid expressed promising activity on SAOS-2 monolayers, the cells showing viability of only 55%, as well as apoptosis features and important gene expression modulation, especially Bid downregulation. Therefore, the newly developed compound should be considered a promising candidate for further in vitro and in vivo research related to osteosarcoma therapy.

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Section: Introductionmentioning

confidence: 99%

The Biological Impact of Some Phosphonic and Phosphinic Acid Derivatives on Human Osteosarcoma

Khaled,

Ilia,

Watz

et al. 2024

CIMB

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“…To cope with the scarcity of inorganic phosphate, many microorganisms have developed peculiar strategies, one of which is scavenging the phosphorus from environmentally available phosphonates [14][15][16]. Several different types of microorganisms are able to degrade phosphonates, including fungi [17,18] and possibly Archaea [19], but by far the most abundant information has been collected on bacteria. In bacteria, the study is facilitated by the tendency of genes involved in the same metabolism to be grouped in operons or clusters [20].…”

Section: Introductionmentioning

confidence: 99%

The Microbial Degradation of Natural and Anthropogenic Phosphonates

Ruffolo,

Dinhof,

Murray

et al. 2023

Molecules

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Phosphonates are compounds containing a direct carbon–phosphorus (C–P) bond, which is particularly resistant to chemical and enzymatic degradation. They are environmentally ubiquitous: some of them are produced by microorganisms and invertebrates, whereas others derive from anthropogenic activities. Because of their chemical stability and potential toxicity, man-made phosphonates pose pollution problems, and many studies have tried to identify biocompatible systems for their elimination. On the other hand, phosphonates are a resource for microorganisms living in environments where the availability of phosphate is limited; thus, bacteria in particular have evolved systems to uptake and catabolize phosphonates. Such systems can be either selective for a narrow subset of compounds or show a broader specificity. The role, distribution, and evolution of microbial genes and enzymes dedicated to phosphonate degradation, as well as their regulation, have been the subjects of substantial studies. At least three enzyme systems have been identified so far, schematically distinguished based on the mechanism by which the C–P bond is ultimately cleaved—i.e., through either a hydrolytic, radical, or oxidative reaction. This review summarizes our current understanding of the molecular systems and pathways that serve to catabolize phosphonates, as well as the regulatory mechanisms that govern their activity.

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N-phosphonomethylglycine utilization by the psychrotolerant yeast Solicoccozyma terricola M 3.1.4.

Stosiek

Terebieniec

Ząbek

et al. 2019

Bioorganic Chemistry

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Phosphate-independent utilization of phosphonoacetic acid as sole phosphorus source by a psychrophilic strain of Geomyces pannorum P15

Cited by 4 publications

References 40 publications

The Biological Impact of Some Phosphonic and Phosphinic Acid Derivatives on Human Osteosarcoma

The Biological Impact of Some Phosphonic and Phosphinic Acid Derivatives on Human Osteosarcoma

The Microbial Degradation of Natural and Anthropogenic Phosphonates

N-phosphonomethylglycine utilization by the psychrotolerant yeast Solicoccozyma terricola M 3.1.4.

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