Phosphate metabolism and vitamin D

Fukumoto, Seiji

doi:10.1038/bonekey.2013.231

Cited by 128 publications

(115 citation statements)

References 58 publications

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“…The concentration of intact FGF23 in fetal blood from WT fetuses was equal to the simultaneous maternal level in mice from the outbred Black Swiss strain for several mouse models (395), whereas the level was about half the maternal value in WT fetuses from the inbred C57BL/6 strain (194,395). The maternal value in turn was approximately double the nonpregnant level as revealed through longitudinal studies in both strains of mice (194).…”

Section: Fgf23mentioning

confidence: 85%

“…The maternal value in turn was approximately double the nonpregnant level as revealed through longitudinal studies in both strains of mice (194). The discrepancy in the fetal FGF23 blood levels between the Black Swiss and C57BL/6 mice, within the same laboratory and using the same intact FGF23 assay, indicates that the genetic background of the mice influences fetal FGF23 physiology.…”

Section: Fgf23mentioning

confidence: 93%

See 1 more Smart Citation

Bone Development and Mineral Homeostasis in the Fetus and Neonate: Roles of the Calciotropic and Phosphotropic Hormones

Kovacs

2014

Physiological Reviews

211

188

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Mineral and bone metabolism are regulated differently in utero compared with the adult. The fetal kidneys, intestines, and skeleton are not dominant sources of mineral supply for the fetus. Instead, the placenta meets the fetal need for mineral by actively transporting calcium, phosphorus, and magnesium from the maternal circulation. These minerals are maintained in the fetal circulation at higher concentrations than in the mother and normal adult, and such high levels appear necessary for the developing skeleton to accrete a normal amount of mineral by term. Parathyroid hormone (PTH) and calcitriol circulate at low concentrations in the fetal circulation. Fetal bone development and the regulation of serum minerals are critically dependent on PTH and PTH-related protein, but not vitamin D/calcitriol, fibroblast growth factor-23, calcitonin, or the sex steroids. After birth, the serum calcium falls and phosphorus rises before gradually reaching adult values over the subsequent 24 -48 h. The intestines are the main source of mineral for the neonate, while the kidneys reabsorb mineral, and bone turnover contributes mineral to the circulation. This switch in the regulation of mineral homeostasis is triggered by loss of the placenta and a postnatal fall in serum calcium, and is followed in sequence by a rise in PTH and then an increase in calcitriol. Intestinal calcium absorption is initially a passive process facilitated by lactose, but later becomes active and calcitriol-dependent. However, calcitriol's role can be bypassed by increasing the calcium content of the diet, or by parenteral administration of calcium.

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Section: Fgf23mentioning

confidence: 85%

Section: Fgf23mentioning

confidence: 93%

Bone Development and Mineral Homeostasis in the Fetus and Neonate: Roles of the Calciotropic and Phosphotropic Hormones

Kovacs

2014

Physiological Reviews

211

188

View full text Add to dashboard Cite

show abstract

“…Phosphate is essential for the mineralization of the bone; indeed 85% of phosphate localises in bone and teeth, complexed with calcium in the form of hydroxyapatite crystals or as amorphous calcium phosphate. Organismal phosphate homeostasis is primarily regulated, by different organs and at multiple levels, by vitamin D, parathyroid hormone, and fibroblast growth factor-23 (FGF-23) [55,56]. The fact that alterations of human phosphate metabolism are implicated in several pathological states makes this topic very important.…”

Section: Inositol Pyrophosphates As Metabolic Regulatorsmentioning

confidence: 99%

Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective

Azevedo

Saiardi

2017

Trends in Biochemical Sciences

138

129

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“…In contrast, expression levels of renal 1-a hydroxylase (CYP27B1), namely the enzyme which converts 1,25-hydroxycholecalciferol into 1,25-dihydroxycholecalciferol, are positively regulated by high calcium and phosphate levels parathyroid hormone (PTH), calcitonin, growth hormone, and insulin-like growth factor-I (IGF-I) (Henry, 2011). Conversely, low calcium and phosphate levels, fibroblast growth factor 23 (FGF23), and 1,25(OH) 2 D 3 itself function as negative regulators of this enzyme (Fukumoto, 2014). However, PTH and 1a,25(OH) 2 D 3 have no effect on the expression and/or activity of extrarenal 1a-hydroxylase.…”

Section: Vit D Chemical Structure Biological Functions and Metabolismmentioning

confidence: 99%

Vitamin D in cancer chemoprevention

Giammanco¹,

Majo²,

Guardia

et al. 2015

Pharmaceutical Biology

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Context: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides their well-known calcium-related functions, may also exert antiproliferative, pro-differentiating, and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo. Objective: The aim of this review is to provide fresh insight into the most recent advances on the role of Vit D and its analogues as chemopreventive drugs in cancer therapy. Methods: A systematic review of experimental and clinical studies on Vit D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar. Results and conclusion: Experimental and clinical observations suggest that Vit D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer, prostate cancer, colorectal cancer, and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents.

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Phosphate metabolism and vitamin D

Abstract: Phosphate plays many essential roles in our body. To accomplish these functions, serum phosphate needs to be maintained in a certain range.

Cited by 128 publications

References 58 publications

Bone Development and Mineral Homeostasis in the Fetus and Neonate: Roles of the Calciotropic and Phosphotropic Hormones

Bone Development and Mineral Homeostasis in the Fetus and Neonate: Roles of the Calciotropic and Phosphotropic Hormones

Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective

Vitamin D in cancer chemoprevention

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