Phosphate transport in the kidney

Effect of growth hormone therapy on bone metabolism of growth hormone deficient children

“…Thus, the increase in PTH levels which was observed in our study, must have counteracted the GH eect on renal phosphate handling. Finally, the possibility that the additional increase in 1,25(OH) 2 vitD levels observed after 6 months of therapy, may have contributed to the stimulatory eect of GH/IGF-I on tubular PO 4 reabsorption cannot be excluded, as 1,25(OH) 2 vitD can variously stimulate or decrease the renal PO 4 reabsorption according to the experimental conditions [4,18]. There are contradictory reports on serum PTH levels following GH administration [3,19].…”

Vitamin D3 and the renal handling of phosphate in American eels

“…In the present study Pi levels in the urine do not significantly drop below those seen in the plasma and thus the Pi was not moved against a chemical gradient. On the other hand, if the same electrical gradient seen in mammals (blood side, negative) exists across the fish renal tubule then the Pi would be moving against its electrical gradient (Bonjour and Caverzasio 1984) necessitating some form of active transport.…”

Phosphate transport processes in eukaryotic cells

“…The physiological aspects of renal phosphate transport and its regulation have been reviewed extensively elsewhere (Bonjour & Caverzasio, 1984;Mizgala & Quamme, 1985;Gmaj & Muter, 1986) and only a summary will be presented here to place the mechanistic and molecular studies in context. Renal Pi resorption plays a major role in whole body P~ homeostasis and is also important in maintenance of acid-base balance.…”