Phosphatidylcholine formation from exogenous lysophosphatidylcholine in isolated hamster heart

Savard, Jeannine D.; Choy, Patrick C.

doi:10.1016/0005-2760(82)90007-8

Cited by 25 publications

(11 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1-Acyl-2-lysophosphatidylcholine bound to albumin is taken up by several organs (Illingworth and Portman, 1972;Portman and Illingworth, 1974;Savard and Choy, 1982). However, the utilization of the 2-acyl isomer has only been studied using cultured cells (Morash et al, 1989), and no data have been reported in vivo.…”

Section: Discussionmentioning

confidence: 99%

“…It has been postulated that plasma lipids containing choline could be a source of choline for the brain (Ansell and Spanner, 1971Spanner, , 1975Spanner et al, 1976). Plasma lysophosphatidylcholine bound to albumin, an important phospholipid class in plasma (Switzer and Eder, 1965), is taken up by several organs (Stein and Stein, 1966;Illingworth and Portman, 1972;Portman and Illingworth, 1974;Savard and Choy, 1982). All these works were mainly focused on the utilization of 1 -acyl-lysophosphatidylcholine and, in particular, 1-palmitoyl-lysophosphatidylcholine.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Unsaturated Fatty Acids Esterified in 2‐Acyl‐1‐Lysophosphatidylcholine Bound to Albumin Are More Efficiently Taken up by the Young Rat Brain than the Unesterified Form

Thiès¹,

Delachambre²,

Bentéjac

et al. 1992

Journal of Neurochemistry

118

View full text Add to dashboard Cite

The aim of the present study was to investigate whether unsaturated 2‐acyl‐lysophosphatidylcholine bound to plasma albumin is a relevant delivery form of unsaturated fatty acids to the developing brain. Twenty‐day‐old rats were perfused for 30 s with labeled palmitic, oleic, linoleic, and arachidonic acids in either their unesterified form or esterified in 2‐acyl‐lysophosphatidylcholine labeled on the choline and fatty acid moieties. Both forms were bound to albumin. Incorporation in brain lipid classes was followed within 1 h. The brain uptake of the unesterified fatty acids reached a plateau at 5–155 mim and was maximal for arachidonic acid (0.45% of the perfused dose). The brain uptake of palmitoyl‐lysophosphatidylcholine was similar to that of palmitic acid, whereas that of other lysophosphatidylcholines increased with the degree of unsaturation (rate and maximal uptake) and was six‐ to 10‐fold higher than that of the corresponding unesterified fatty acid. 2‐Acyl‐lysophosphatidylcholines were taken up without prior hydrolysis and reacylated into doubly labeled phosphatidylcholine, which was the most labeled lipid class, whereas lipid distribution of the unesterified fatty acid was more diversi fied. Partial hydrolysis of 2‐acyl‐lysophosphatidylcholine occurred in the brain tissue, and redistribution of the fatty acyl moiety into other phospholipid classes was also observed and was the highest for arachidonic acid. In this case, the percentage of esterification of this fatty acid in phosphatidylinositol (expressed as a percentage of the total lipid fraction) was relatively lower than that observed when the unesterified form was used. 1‐Acyl‐lysophosphatidylcholine (palmitoyl) was taken at the same extent that 2‐acyllysophosphatidylcholine but was more hydrolyzed and reesterified in other lipid classes than 2‐acyl isomer. All these results suggest that 2‐acyl‐lysophosphatidylcholine bound to albumin could be an efficient delivery form of unsaturated fatty acids to the developing rat brain and that the fatty acid delivery form could modulate their fate in the tissue.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Unsaturated Fatty Acids Esterified in 2‐Acyl‐1‐Lysophosphatidylcholine Bound to Albumin Are More Efficiently Taken up by the Young Rat Brain than the Unesterified Form

Thiès¹,

Delachambre²,

Bentéjac

et al. 1992

Journal of Neurochemistry

118

View full text Add to dashboard Cite

show abstract

“…1985; Graham er al. 1988) and other studies with non-ruminants show that it can be taken up by tissues and used for phospholipid synthesis (Illingworth & Portman, 1972;Savard & Choy, 1982). The plasma lipids of sheep contain 2-3 g IysophosphatidylcholindlOO g (Christie, 1981) and this lipid is relatively rich in linoleic acid (Noble et a f .…”

Section: Vol 47mentioning

confidence: 99%

Lipid Metabolism in Farm Animals

Vernon

Flint

1988

Proc. Nutr. Soc.

View full text Add to dashboard Cite

“…Lysophospholipids such as LPC can be reacylated in the mammalian heart to form phosphatidylcholine, the parent compound of LPC. Alternatively, LPC can be hydrolyzed by lysophospholipase into glycerol phosphocholine and fatty acids (Savard & Choy, 1982). Hence the accumulation of LPC in the present study represented the total uptake of LPC reduced by the amount of LPC metabolized.…”

Section: Discussionmentioning

confidence: 72%

Lysophosphatidylcholine‐induced arrhythmias and its accumulation in the rat perfused heart

Man

1988

British J Pharmacology

View full text Add to dashboard Cite

The tissue level of lysophosphatidylcholine (LPC) was determined in rat hearts perfused with a solution containing 5 μm LPC. The relationship between LPC accumulation and the severity of arrhythmias produced was examined. The accumulation of LPC was dependent on the perfusion time and this accumulation was associated with the occurrence of severe arrhythmias. A positive correlation between the tissue LPC content and the arrhythmia score was found (P < 0.01). No consistent alteration in total phospholipid, phosphatidylcholine or cholesterol content was found. This suggests that LPC‐induced arrhythmias are not associated with alterations of major lipid components in the heart. When severe arrhythmias occurred in the presence of LPC in the rat perfused heart, less than 2% of total tissue phospholipid was in the form of LPC. The positive correlation between LPC accumulation and the occurrence of arrhythmias suggests a cause and effect relationship of LPC with cardiac arrhythmias in the rat perfused heart. However, in the ischaemic heart, other biochemical factors can contribute, to different degrees, to ischaemia‐induced cardiac arrhythmias.

show abstract

Phosphatidylcholine formation from exogenous lysophosphatidylcholine in isolated hamster heart

Cited by 25 publications

References 20 publications

Unsaturated Fatty Acids Esterified in 2‐Acyl‐1‐Lysophosphatidylcholine Bound to Albumin Are More Efficiently Taken up by the Young Rat Brain than the Unesterified Form

Unsaturated Fatty Acids Esterified in 2‐Acyl‐1‐Lysophosphatidylcholine Bound to Albumin Are More Efficiently Taken up by the Young Rat Brain than the Unesterified Form

Lipid Metabolism in Farm Animals

Lysophosphatidylcholine‐induced arrhythmias and its accumulation in the rat perfused heart

Contact Info

Product

Resources

About