Phosphatidylethanol Compared with Other Blood Tests as a Biomarker of Moderate Alcohol Consumption in Healthy Volunteers: A Prospective Randomized Study

Abstract

PEth was the only marker that could detect moderate intake and the present results also indicate that PEth probably can distinguish moderate alcohol consumption from abstinence.

High prevalence of unhealthy alcohol use and comparison of self-reported alcohol consumption to phosphatidylethanol among women engaged in sex work and their male clients in Cambodia

“…In this study, we opted for a more conservative approach and used PEth ≥50 ng/ml as a measure of unhealthy alcohol consumption, including moderate at-risk drinking and alcohol-use disorders. This decision is supported by recent studies showing that PEth can distinguish moderate to heavy alcohol drinkers from light drinkers or those who are abstinent (Stewart et al, 2014; Kechagias et al, 2015). …”

Low to moderate lifetime alcohol consumption is associated with less advanced stages of fibrosis in non-alcoholic fatty liver disease

“…Thus, these thirteen subjects would have been included as unbiased NAFLD cases in any other study not using PEth. In a previous randomized controlled trial, consumption of 150 ml of red wine for women and 300 ml for men per day for three months did not elevate PEth > 0.3 μmol/L in a single subject [27], indicating that these 13 subjects potentially drank more than these amounts.…”

Sparse canonical correlation analysis between an alcohol biomarker and self-reported alcohol consumption

“…Our colleagues are interested not only in determining the effect of naltrexone, but also in measuring the correlation between the two measures of consumption. Previous studies have indicated that PEth is well correlated with alcohol intake and has a detection window of 1 to 3 weeks following back such as Aradottir et al (2006), Stewart et al (2009), Hahn et al (2012), Helander et al (2012), Viel et al (2012), Jain et al (2014), and Kechagias et al (2015). Standard drink units (SDUs) are typically used to quantify alcohol consumption; one SDU corresponds to 0.6 ounces of pure alcohol, which is approximately one 12 ounce 5% alcohol by volume (ABV) beer, one 5 ounce glass of wine, or 1.5 ounces of a 40% ABV spirit.…”