Phosphatidylglycerol determination on amniotic fluid 10,000 × g pellet in the prediction of fetal lung maturity

Bent, Alfred E.; Gray, J.H.; Luther, Edwin R.; Oulton, M.; Peddle, L. J.

doi:10.1016/0002-9378(81)90005-3

Cited by 17 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The low predictive accu racy of undetectable PG levels has also been demon strated in several other reports [14][15][16]. PG was shown to be absent in 10% of amniotic samples at 40 weeks of gestation in the work of Golde and Mosley [17], and in one third of the near-term samples studied by Cun ningham et al [11].…”

Section: ]mentioning

confidence: 79%

Comparison of Amniotic Fluid Disaturated Phosphatidylcholine, Phosphatidylglycerol and Lecithin/Sphingomyelin Ratio in Predicting the Risk of Developing Neonatal Respiratory Distress Syndrome

Higuchi

Hirano

Gotoh

et al. 1990

Gynecol Obstet Invest

View full text Add to dashboard Cite

One hundred forty-one amniotic fluid samples were analyzed for disaturated phosphatidylcholine (DSPC), phosphatidylglycerol (PG) and the lecithin/sphingomyelin (L/S) ratio. The L/S ratio was measured by two-dimensional thin layer chromatography. Mature levels (positive) were defined as an L/S ratio of 2:1 or more, a DSPC level of 100 µg/ml or more and a detectable level of PG. The DSPC value agreed with the L/S ratio in 114 samples (80.9%). Fourteen of 17 infants with respiratory distress syndrome (RDS) (82.4%) had immature L/S ratios and immature DSPC levels. RDS developed in 16 of 40 (40%) children with immature L/S ratios, and in 15 of 33 (45.5%) children with immature DSPC levels. The true-positive rates of the L/S ratio and DSPC levels were 99.0 and 98.1 %, respectively. PG had a low true-negative rate, as only 17 of 67 (25.4%) samples without detectable levels of PG were associated with RDS. However, when PG was present, it had a 100% predictive value of no-RDS. In conclusion, DSPC is nearly equal to the L/S ratio measured by two-dimensional as concerns diagnostic accuracy. PG is useful as an additional index for predicting lung maturation.

show abstract

Section: ]mentioning

confidence: 79%

Comparison of Amniotic Fluid Disaturated Phosphatidylcholine, Phosphatidylglycerol and Lecithin/Sphingomyelin Ratio in Predicting the Risk of Developing Neonatal Respiratory Distress Syndrome

Higuchi

Hirano

Gotoh

et al. 1990

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…The phosphatidylglycerol (PG) assay has replaced the L/S ratio as an index of fetal maturity, and when PG exceeds one per cent there is minimal risk of RDS. 63 Very strict control of the maternal blood glucose in labour (5.5-6.5mMol'L -~) avoids hypoglycaemia, which may interfere with the progress of labour, and hyperglycaemia, which may promote increased fetal insulin production, fetal distress and neonatal hypoglycaemia. In addition, maternal (and consequently fetal) hyperglycaemia accentuates fetal metabolic acidosis, especially that secondary to hypoxia.…”

Section: Management Of Labour and Deliverymentioning

confidence: 99%