Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein Facilitates Glioma Progression via Akt and Stat3 Signaling

Shang, Jinxing; Li, Yabin; Yin, Gangfeng; Li, Zhuangzhuang; Jiang, Lijun; Bai, Qingling

doi:10.1007/s12031-021-01883-x

Cited by 2 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has multiple effects on a variety of tumors, including lung cancer (21). In addition, the STAT3/AKT axis has been determined to mediate the migration, invasion and metastasis of tumors (10,20,(21)(22)(23). Notably, the present data revealed that MUC21 promoted the migration and invasion of GBM cells via the STAT3/AKT axis, which provided new evidence of MUC21 as an effective therapeutic target for GBM.…”

Section: Discussionsupporting

confidence: 53%

MUC21 induces the viability and migration of glioblastoma via the STAT3/AKT pathway

Wang

Zhang

et al. 2022

Exp Ther Med

View full text Add to dashboard Cite

Glioblastoma (GBM) is a malignant tumor with one of the fastest increasing morbidity and mortality rates. As such, more therapeutic targets need to be developed to combat this disease. Mucin 21 (MUC21) is a human counterpart of mouse epiglycanin and mediates multiple cellular functions. However, its possible effects on GBM and its possible mechanism remain unclear. The current study aimed to clarify the role or MUC21 in the progression of GBM by performing a series of in vitro assays, including Cell Counting Kit-8, colony formation, wound closure, transwell, and in vivo assays. In the present study, the aberrantly high expression of MUC21 in human GBM tissues and cell lines was observed and it was revealed that it was associated with the clinicopathological feature, tumor recurrence, in patients with GBM. MUC21 promoted the viability and motility of GBM cells in vitro and stimulated tumor growth in vivo. It was further confirmed that MUC21 promoted the progression of GBM via the STAT3/AKT pathway and it was considered that MUC21 could serve as a promising target for the treatment of GBM.

show abstract

Section: Discussionsupporting

confidence: 53%

MUC21 induces the viability and migration of glioblastoma via the STAT3/AKT pathway

Wang

Zhang

et al. 2022

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…According to Schoenegger K's criteria [ 5 ], PTE was defined as high T2 signal intensity on the tumor margin. On the basis of the distance from the outer edge of abnormally high signal to tumor margin on T2-weighted images, PTE was divided into two levels including <1 cm and ≥1 cm ( Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%

“…Such characteristics make HGG difficult to be completely healed by operation, chemotherapy, radiotherapy, target therapy, and other treatments [2][3][4]. GBM as a kind of HGG accounts for about 25% of gliomas [5]. Generally, patients with HGG have poor prog-nosis owing to the high rate of recurrence in the short term [6]; the median overall survival (OS) of anaplastic astrocytoma patients is about 3 years [7], while that of GBM patients is less than 14 months [8].…”

Section: Introductionmentioning

confidence: 99%

Peritumor Edema Serves as an Independent Predictive Factor of Recurrence Patterns and Recurrence-Free Survival for High-Grade Glioma

Chen

Qiu

Chen

et al. 2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

Objective. This study is aimed at analyzing the factors affecting the recurrence patterns and recurrence-free survival (RFS) of high-grade gliomas (HGG). Methods. Eligible patients admitted to the Affiliated Hospital of Xuzhou Medical University were selected. Subsequently, the effects of some clinical data including age, gender, WHO pathological grades, tumor site, tumor size, clinical treatments, and peritumoral edema (PTE) area and molecular markers (Ki-67, MGMT, IDH-1, and p53) on HGG patients’ recurrence patterns and RFS were analyzed. Results. A total number of 77 patients were enrolled into this study. After analyzing all the cases, it was determined that tumor size and tumor site had a significant influence on the recurrent patterns of HGG, and PTE was an independent predict factor of recurrence patterns. Specifically, when the PTE was mild (<1 cm), the recurrence pattern tended to be local; in contrast, HGG was more likely to progress to marginal recurrence and distant recurrence. Furthermore, age and PTE were significantly associated with RFS; the median RFS of the population with PTE < 1 cm (23.60 months) was obviously longer than the population with PTE ≥ 1 cm (5.00 months). Conclusions. PTE is an independent predictor of recurrence patterns and RFS for HGG. Therefore, preoperative identification of PTE in HGG patients is crucially important, which is helpful to accurately estimate the recurrence pattern and RFS.

show abstract

Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein Facilitates Glioma Progression via Akt and Stat3 Signaling

Cited by 2 publications

References 32 publications

MUC21 induces the viability and migration of glioblastoma via the STAT3/AKT pathway

MUC21 induces the viability and migration of glioblastoma via the STAT3/AKT pathway

Peritumor Edema Serves as an Independent Predictive Factor of Recurrence Patterns and Recurrence-Free Survival for High-Grade Glioma

Contact Info

Product

Resources

About