Phosphatidylinositol (3,5)-bisphosphate machinery regulates neurite thickness through neuron-specific endosomal protein NSG1/NEEP21

Qi, Lijuan; Sun, Cheng; Sun, Shenqing; Li, Aiqing; Hu, Qiuming; Liu, Yaobo; Zhang, Yanling

doi:10.1016/j.jbc.2022.102775

Cited by 1 publication

(1 citation statement)

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“…To further explore the mechanism of action of miR-107 in HSCC, we screened the possible downstream target gene NSG1 of miR-107 through bioinformatics analysis. In previous studies, NSG1 was mainly related to the nervous system, especially the structure and function of nerve cells [ 13 ]. However, in recent years, increasingly more studies have been conducted on the relationship between NSG1 and the occurrence and development of malignant tumors.…”

Section: Introductionmentioning

confidence: 99%

miR-107 Targets NSG1 to Regulate Hypopharyngeal Squamous Cell Carcinoma Progression through ERK Pathway

Hu,

He,

Han

et al. 2024

IJMS

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Hypopharyngeal squamous cell carcinoma (HSCC) is a kind of malignant tumor with a poor prognosis and low quality of life in the otolaryngology department. It has been found that microRNA (miRNA) plays an important role in the occurrence and development of various tumors. This study found that the expression level of miRNA-107 (miR-107) in HSCC was significantly reduced. Subsequently, we screened out the downstream direct target gene Neuronal Vesicle Trafficking Associated 1 (NSG1) related to miR-107 through bioinformatics analysis and found that the expression of NSG1 was increased in HSCC tissues. Following the overexpression of miR-107 in HSCC cells, it was observed that miR-107 directly suppressed NSG1 expression, leading to increased apoptosis, decreased proliferation, and reduced invasion capabilities of HSCC cells. Subsequent experiments involving the overexpression and knockdown of NSG1 in HSCC cells demonstrated that elevated NSG1 levels enhanced cell proliferation, migration, and invasion, while the opposite effect was observed upon NSG1 knockdown. Further investigations revealed that changes in NSG1 levels in the HSCC cells were accompanied by alterations in ERK signaling pathway proteins, suggesting a potential regulatory role of NSG1 in HSCC cell proliferation, migration, and invasion through the ERK pathway. These findings highlight the significance of miR-107 and NSG1 in hypopharyngeal cancer metastasis, offering promising targets for therapeutic interventions and prognostic evaluations for HSCC.

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Section: Introductionmentioning

confidence: 99%