Phosphatidylinositol 3-kinase activity is required for the induction of differentiation in C6 glioma cells by panaxydol

Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: Combinational approach for enhanced differentiation

“…( 53 ) At the same time, it has been reported that some gliomas show strong resistance to the induction of differentiation or apoptosis by retinoids ( 56 ) and hence the alternative drugs including the psychotropic agents phenothiazines, chlorpromazine and perphenazine, N ‐(4‐hydroxyphenyl) retinamide, capsaicin (8‐methyl‐ N ‐vanillyl‐6‐nonenamide), panaxydol, cAMP and cholera toxin have been tested for their glioma therapeutic potential. ( 57–60 ) Apparently, there is a considerable need to develop more effective antiglioma reagents. Based on our present data, we suggest the use of i‐Extract and its constituents (combinational formula) for differentiation‐based milder and effective glioma therapy.…”

In vitro models for neurotoxicology research

“…220 Differentiation of C6 cells with cholera toxin is also associated with increased expression of GFAP. 221 Other agents, including bFGF, 222 platelet-derived growth factor (PDGF), 222 RA, 223,224 histone deacetylase inhibitors (trichostatin A, sodium butyrate or valproic acid) 225,226 or panaxydol, 227 are also described to induce differentiation of the C6 glioma cell line. In addition, differentiation of C6 glioma cells with bFGF plus PDGF generates both neurons and glia in culture.…”