Phosphatidylinositol 4-Kinase Enzymes: Functional Roles and Potential for Drug Target

Tyagi, Manoj; Sukumaran, Deepasree; Das, Saibal Kumar; Tyagi, Vishakha; Vora, Pulastya

doi:10.9790/3008-1201025053

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Pathophysiological Implications For Cdp Diacylglycerol1

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2019

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“…The increase in CDS1 mRNA corresponded to an increase in mitochondrial CDS activity with no change in microsomal CDS activity. It is quite likely that CDP diacylglycerol pathway may be modulating the synthesis of prostaglandins for e.g the prostacyclin and also PI-4 kinase levels [21,22]. Recent data also demonstrates that various anti-depressants increase phosphatidylinositol and CDP-diacylglycerol synthesis probably through stimulation of the enzymatic activity of CDS, the enzyme that synthesizes CDPdiacylglycerol.…”

Section: Pathophysiological Implications For Cdp Diacylglycerolmentioning

confidence: 99%

Functional Roles of Lipid Metabolite CDP Diacylglycerol and Its Synthase Enzymes: Recent Developments

Tyagi

Singh

Nirmala

et al. 2019

JBPR

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Phospholipids are basic building-block molecules for biological membranes. Biosynthesis of phospholipids i.e phosphatidylinositol, phosphatidylglycerol and phosphatidylserine requires a central liponucleotide intermediate named cytidine-diphosphate diacylglycerol (CDP-DAG). The CDP-DAG synthase (CDS) is an integral membrane enzyme catalysing the formation of CDP-DAG, an essential step for phosphoinositide recycling during signal transduction. New roles are being ascribed to the CDP-DAG in signalling and pathophysiological conditions. This pathway may also be the target of novel drugs to be used in neuro-psychiatric conditions. Key words: Phospholipids, Cytidine diphosphate, diacylglycerol, phosphatidic acid, phosphatidylglycerol.

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Section: Pathophysiological Implications For Cdp Diacylglycerolmentioning

confidence: 99%