Phosphatidylserine in the Nervous System: Cytoplasmic Regulator of the AKT and PKC Signaling Pathways and Extracellular “Eat-Me” Signal in Microglial Phagocytosis

Zhuang, Junyi; Zhang, Yuchen; Shu, Huichen; Zhang, Shibo; Zhao, Wanwei; Ward, Natalie; Wang, Jiao

doi:10.1007/s12035-022-03133-6

Cited by 4 publications

(1 citation statement)

References 202 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, PC supplementation demonstrated beneficial effects on intestinal inflammation in patients and in laboratory models [ 47 , 48 , 49 , 50 ]. Likewise, PS is regarded as beneficial for central nervous system health as was demonstrated in animal and human studies, and PS-containing supplements are widely available for everyday use [ 39 , 51 , 52 , 53 ]. Finally, PA can serve as a precursor in PLs biosynthesis, and it is commonly used by sportsmen to facilitate strength and muscle endurance as a mammalian target of rapamycin (mTOR) signaling pathway agonist [ 54 , 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Dietary Phospholipids on the Ultrastructure and Function of Intestinal Epithelial Cells

Saydakova¹,

Morozova

Snytnikova

et al. 2023

IJMS

View full text Add to dashboard Cite

Dietary composition substantially determines human health and affects complex diseases, including obesity, inflammation and cancer. Thus, food supplements have been widely used to accommodate dietary composition to the needs of individuals. Among the promising supplements are dietary phospholipids (PLs) that are commonly found as natural food ingredients and as emulsifier additives. The aim of the present study was to evaluate the effect of major PLs found as food supplements on the morphology of intestinal epithelial cells upon short-term and long-term high-dose feeding in mice. In the present report, the effect of short-term and long-term high dietary PL content was studied in terms of intestinal health and leaky gut syndrome in male mice. We used transmission electron microscopy to evaluate endothelial morphology at the ultrastructural level. We found mitochondrial damage and lipid droplet accumulation in the intracristal space, which rendered mitochondria more sensitive to respiratory uncoupling as shown by a mitochondrial respiration assessment in the intestinal crypts. However, this mitochondrial damage was insufficient to induce intestinal permeability. We propose that high-dose PL treatment impairs mitochondrial morphology and acts through extensive membrane utilization via the mitochondria. The data suggest that PL supplementation should be used with precaution in individuals with mitochondrial disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

The Effect of Dietary Phospholipids on the Ultrastructure and Function of Intestinal Epithelial Cells

Saydakova¹,

Morozova

Snytnikova

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

Microglial Dysfunction in Autism Spectrum Disorder

Meng,

Zhang,

Zhang

2024

Neuroscientist

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder with onset in childhood. The molecular mechanisms underlying ASD have not yet been elucidated completely. Evidence has emerged to support a link between microglial dysfunction and the etiology of ASD. This review summarizes current research on microglial dysfunction in neuroinflammation and synaptic pruning, which are associated with altered transcriptomes and autophagy in ASD. Dysbiosis of gut microbiota in ASD and its correlation with microglial dysfunction are also addressed.

show abstract

Cells and Molecules Underpinning Cannabis-Related Variations in Cortical Thickness during Adolescence

Navarri,

Robertson,

Charfi

et al. 2024

J. Neurosci.

View full text Add to dashboard Cite

During adolescence, cannabis experimentation is common, and its association with interindividual variations in brain maturation well studied. Cellular and molecular underpinnings of these system-level relationships are, however, unclear. We thus conducted a three-step study. First, we exposed adolescent male mice to Δ-9-tetrahydrocannabinol (THC) or a synthetic cannabinoid WIN 55,212-2 (WIN) and assessed differentially expressed genes (DEGs), spine numbers, and dendritic complexity in their frontal cortex. Second, in human (male) adolescents, we examined group differences in cortical thickness in 34 brain regions, using magnetic resonance imaging, between those who experimented with cannabis before age 16 (n = 140) and those who did not (n = 327). Finally, we correlated spatially these group differences with gene expression of human homologs of mouse-identified DEGs. The spatial expression of 13 THC-related human homologs of DEGs correlated with cannabis-related variations in cortical thickness, and virtual histology revealed coexpression patterns of these 13 genes with cell-specific markers of astrocytes, microglia, and a type of pyramidal cells enriched in dendrite-regulating genes. Similarly, the spatial expression of 18 WIN-related human homologs of DEGs correlated with group differences in cortical thickness and showed coexpression patterns with the same three cell types. Gene ontology analysis indicated that 37 THC-related human homologs are enriched in neuron projection development, while 33 WIN-related homologs are enriched in processes associated with learning and memory. In mice, we observed spine loss and lower dendritic complexity in pyramidal cells of THC-exposed animals (vs controls). Experimentation with cannabis during adolescence may influence cortical thickness by impacting glutamatergic synapses and dendritic arborization.

show abstract

Phosphatidylserine in the Nervous System: Cytoplasmic Regulator of the AKT and PKC Signaling Pathways and Extracellular “Eat-Me” Signal in Microglial Phagocytosis

Cited by 4 publications

References 202 publications

The Effect of Dietary Phospholipids on the Ultrastructure and Function of Intestinal Epithelial Cells

The Effect of Dietary Phospholipids on the Ultrastructure and Function of Intestinal Epithelial Cells

Microglial Dysfunction in Autism Spectrum Disorder

Cells and Molecules Underpinning Cannabis-Related Variations in Cortical Thickness during Adolescence

Contact Info

Product

Resources

About