Phosphenium-Komplexe, 43 [1]. Ringöffnungsreaktionen der dreigliedrigen Phosphametallacyclen {PR₂ = P(o-Tol)₂, P(Ph)(o-Tol), P(Mes)[C(S)N(H)Et], P(/-Bu)[C(O)N(H)Et} / Phosphenium Complexes, 43 [1]. Ring-Opening Reactions of the Three-Membered Phosphametallacycles {PR1 = P(o-Tol)2, P(Ph)(oTol), P(Mes)[C(S)N(H)Et], P(r-Bu)[C(0)N(H)Et}

Abstract

The three-membered phosphametallacycles [R = o-Tol (3a), R = Ph(3b)] react with the tertiary phosphanes Me3P (4a), Me2PhP (4b) or MePh2P (4c) with ring opening and deselenation to the metallo-phosphanes fran.s-Cp(OC)2(R3P)WP(o-Tol)(R) (5a-d). Analogous reactions of the P-thioformamido- and formamido-substituted metallacycles [R = Mes, X = S (6a); R = t-Bu, X = O (6b)] with Me3P (4a) yield in the case of 6a the tungsten-phosphane Cp(OC)2(Me3P)W-P(Mes)[C(S)N(H)Et] (7), while 6b affords the tungsten-selenophosphorane Cp(OC)2(Me3P)W-P(Se)(f-Bu)[C(0)N(H)Et] (8 ). Treatment of 7 with hydrogen chloride affords {Cp(OC)2(Me3P)W-P(H)(Mes)[C(S)N(H)Et] }C1 (9). With methyliodide, 8 is transformed into {Cp(OC)2(Me3P)W-P(SeMe)(t-Bu)[C(O)N(H)Et]}I (10)

Non-typeable Haemophilus influenzae major outer membrane protein P5 contributes to bacterial membrane stability, and affects the membrane protein composition crucial for interactions with the human host

“…Lipooligosaccharide (LOS) biosynthesis and assembly are related to protein assembly on the OM (Ried et al, 1990;Bulieris et al, 2003;Spahich et al, 2014). Hence, full P5 deletion might also potentially affect the assembly of LOS and the exposure of surface immunogenic antigens, however, with greater impact than the partial deletion of P5.…”