Phosphine-induced oxidative damage in rats: attenuation by melatonin

Hsu, Ching Hung; Han, Bor-Cheng; Liu, Ming Yie; Yeh, Chien-Yuh; Casida, John E.

doi:10.1016/s0891-5849(99)00277-4

Cited by 103 publications

(91 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different studies in rats (86,87) and humans (66) have revealed that N-acetylcysteine can help as it replenishes cellular glutathione and magnesium, in addition to its antioxidant properties. In rats exposed to AlP, N-acetylcysteine increased survival time and reduced myocardial oxidative injury (4).…”

Section: N-acetylcysteinementioning

confidence: 99%

See 1 more Smart Citation

A Systematic Review of Aluminium Phosphide Poisoning

Mehrpour¹,

Jafarzadeh

Abdollahi

2012

Archives of Industrial Hygiene and Toxicology

161

214

View full text Add to dashboard Cite

Every year, about 300,000 people die because of pesticide poisoning worldwide. The most common pesticide agents are organophosphates and phosphides, aluminium phosphide (AlP) in particular. AlP is known as a suicide poison that can easily be bought and has no effective antidote. Its toxicity results from the release of phosphine gas as the tablet gets into contact with moisture. Phosphine gas primarily affects the heart, lungs, gastrointestinal tract, and kidneys. Poisoning signs and symptoms include nausea, vomiting, restlessness, abdominal pain, palpitation, refractory shock, cardiac arrhythmias, pulmonary oedema, dyspnoea, cyanosis, and sensory alterations. Diagnosis is based on clinical suspicion, positive silver nitrate paper test to phosphine, and gastric aspirate and viscera biochemistry. Treatment includes early gastric lavage with potassium permanganate or a combination with coconut oil and sodium bicarbonate, administration of charcoal, and palliative care. Specifi c therapy includes intravenous magnesium sulphate and oral coconut oil. Moreover, acidosis can be treated with early intravenous administration of sodium bicarbonate, cardiogenic shock with fl uid, vasopresor, and refractory cardiogenic shock with intra-aortic baloon pump or digoxin. Trimetazidine may also have a useful role in the treatment, because it can stop ventricular ectopic beats and bigeminy and preserve oxidative metabolism. This article reviews the epidemiological, toxicological, and clinical/pathological aspects of AlP poisoning and its management.

show abstract

Section: N-acetylcysteinementioning

confidence: 99%

“…There are reports of the positive clinical effects of coconut oil against AlP poisoning in humans (9,86). Its mechanism of action is unclear, but it may form a protective layer around the gastric mucosa and prevent the absorption of phosphine gas.…”

Section: Coconut and Almond Oilmentioning

confidence: 99%

A Systematic Review of Aluminium Phosphide Poisoning

Mehrpour¹,

Jafarzadeh

Abdollahi

2012

Archives of Industrial Hygiene and Toxicology

161

214

View full text Add to dashboard Cite

show abstract

“…(7) Zinc phosphides induces oxidative stress. (8) It inhibits the activity of catalase (CAT) and peroxidase and stimulates superoxide dismutase (SOD). (9) It elevates malondialdehyde (MDA) levels in cardiac tissues.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Potential Oxidative Stress in Egyptian Patients with Acute Zinc Phosphide Poisoning and the Role of Vitamin C

Sagah

Oreby

Elgharabawy³

et al. 2015

IJHS

View full text Add to dashboard Cite

Objective: To evaluate potential oxidative stress in patients with acute phosphide poisoning and the effect of vitamin C. Methods:Participants were females and divided into three groups; group I: healthy volunteers group II: healthy volunteers received vitamin C, group III: patients with acute phosphide poisoning received the supportive and symptomatic treatment and group IV: patients with acute phosphide poisoning received the supportive and symptomatic treatment in addition to vitamin C. All the participants were subjected to thorough history, clinical examination, ECG and laboratory investigations were carried on collected blood and gastric lavage samples on admission. Blood samples were divided into two parts, one for measurement of routine investigations and the second part was used for evaluation of malondialdehyde and total thiol levels before and after receiving the treatment regimen.Results: Most of the cases in this study were among the age group of 15-25 years, females, single, secondary school education, from rural areas and suicidal. All vital signs were within normal range and the most common complaint was vomiting and abdominal pain. All cases in this study showed normal routine investigations. The mean MDA levels after receiving treatment decreased significantly in groups II and IV. The mean total thiol levels increased significantly after receiving treatment in groups II and IV. Conclusion:It can be concluded that vitamin C has a potential benefit due to its antioxidant property on zinc phosphide induced-oxidative stress in acute zinc phosphide poisoned patients.

show abstract

“…[53][54][55][56][57] A number of studies have shown that melatonin is significantly better than the classic antioxidants in resisting free-radical-based molecular destruction. In these studies, melatonin was more effective than vitamin E. [58][59][60] β-carotene, 61 and vitamin C. 62,63 This effect is indirect, owing to its ability to scavenge free radicals and protect the protein from damage. Our study offers encouraging data supporting storage of whole blood with melatonin for at least 21 days.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Melatonin on Oxidative Damage Observed During Whole Blood Storage.

Ozcelik¹

2014

UHOD

View full text Add to dashboard Cite

It is well known that oxidative stress rises during the storing period of whole blood and there has been a great interest to improve the quality of stored blood for longer periods. In the present study, we determine the effects of melatonin as an antioxidant on the whole blood indices stored under blood bank conditions. Human blood was collected by venipuncture into citrate-dextrose-phosphate (CDP) bags from healthy volunteers. Immediately after collection, blood was subdivided into two parts and exposed to either melatonin or control saline solutions. Several biochemical parameters were measured on the day of collection and at weekly intervals up to 3 weeks. Mean corpuscular and platelet volumes tended to increase during storing process and with melatonin, these indices remained near to physiologic levels. As expected, acidity, oxidative damage and osmotic fragility increased in stored blood. Interestingly addition of melatonin reduced acidity, oxidative damage by lowering malondialdehyde levels and by increasing superoxide dismutase activity, and osmotic fragility during storage without adversely affecting other biochemical parameters. pH was 6.68 ±0.04 in day 14 of control group while it was 7.00 ± 0.03 in melatonin group. Malondialdehyde level was 1.223±0.05 in day 21 of control group while it was 0.723±0.04 in melatonin group (p< 0.05).Superoxide dismutase activity was significantly higher in melatonin group at days 14 and 21 (151.3±12.2 and 82.8±9.2) compared to saline (111.8±6.5 and 44.8±3.0) (p< 0.05). Through these results, we could confirm a central role for oxidative stress in the mechanism of the most evident blood storage lesions and melatonin seems to exhibit beneficial effects on these lesions. Keywords: Whole blood storage, Oxidative stress, Melatonin ÖZET Kanın Depolanmasında Görülen Oksidatif Hasarda Melatoninin Koruyucu EtkileriKanın depolanması sırasında oksidatif stresin arttığı iyi bilinmekte ve depo kanın kalitesinin daha uzun sürelerle korunması için yoğun çalışmalar yapılmaktadır. Bu çalışmada, kan bankası şartlarında saklanan tam kan örneklerinde bir antioksidan olan melatoninin etkisi araştırılmıştır. Sağlıklı gönüllü bir grup insandan venöz kan örnekleri, antikoagulanlı torbalara alınmıştır. Bağıştan hemen sonra kan, kontrol grubu ve melatonin grubu olarak iki gruba ayrılmış ve bağış gününde ve sonraki üç hafta boyunca her hafta çeşitli biyokimyasal analizler yapılmıştır. Ortalama eritrosit ve trombosit hacim değerleri saklama boyunca artmış, ancak melatoninle bu değerler normale yakın seyretmiştir. Beklendiği gibi, saklanan kanda asidite, ozmotik frajilite ve oksidatif hasar artmıştır. İlginç olarak, melatonin ilavesi asiditeyi, ozmotik frajiliteyi ve oksidatif hasarı (malondialdehit seviyelerini azaltıp superoksit dismutaz aktivitesini artırarak) anlamlı olarak düşürmüştür.Kontrol grubunda 14. gün pH değeri 6.68±0.04 iken, melatonin grubunda bu değer 7.00 ± 0.03 idi. Malondialdehit düzeyi kontrol grubunda

show abstract

Phosphine-induced oxidative damage in rats: attenuation by melatonin

Cited by 103 publications

References 36 publications

A Systematic Review of Aluminium Phosphide Poisoning

A Systematic Review of Aluminium Phosphide Poisoning

Evaluation of Potential Oxidative Stress in Egyptian Patients with Acute Zinc Phosphide Poisoning and the Role of Vitamin C

Beneficial Effects of Melatonin on Oxidative Damage Observed During Whole Blood Storage.

Contact Info

Product

Resources

About