Phosphodiesterase-III inhibitors amrinone and milrinone on epilepsy and cardiovascular activities

Asif, Mohammad

doi:10.4103/1947-2714.102001

North Am J Med Sci

2012

DOI: 10.4103/1947-2714.102001

|View full text |Cite

Phosphodiesterase-III inhibitors amrinone and milrinone on epilepsy and cardiovascular activities

Mohammad Asif

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2021

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 6 publications

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Experimental and theoretical studies of 1,3,5‐tris (bromomethyl)‐2,4,6‐trimethylbenzene with 2‐pyridone

Asha

Rahini

Daisy

et al. 2021

J of Physical Organic Chem

View full text Add to dashboard Cite

In this present work, a new compound 1- ({2,4,methyl]phenyl}methyl)-2H-pyridin-2-one hydrate (M3P) has been synthesized and characterized by IR, 1 H, and 13 C NMR and single-crystal X-ray diffraction analysis. The molecular geometry, frontier molecular orbital energies, and thermodynamic properties of the title molecule were explored using density functional theory (DFT) calculation via B3LYP method with 631 ++G (d,p) basis set. The compound (M3P) crystallizes in the space group of P-1 with unit cell parameter a = 9.8224(12) Å, b = 11.6383(14) Å, c = 11.8865 (14) Å, α = 64.6410(10) , β = 81.156(2) , γ = 69.5910(10) , V = 1150.8(2) Å3,and Z = 2. Furthermore, Hirshfeld surface analysis was performed to observe better intermolecular interactions in the crystal packing. The nature of the interaction of M3P with DNA and BSA protein was studied using molecular docking analysis. DNA binding studies were also done using UV spectrophotometric method. The compound moderately binds with CT-DNA which is comparable with the docking results. in vitro anti-microbial activities against some bacterial and fungal strains were investigated. M3P shows good response against bacteria Pseudomonas aeruginosa and Klebsiella pneumonia and fungi Candida albicans and Aspergillus niger.

show abstract

Experimental and theoretical studies of 1,3,5‐tris (bromomethyl)‐2,4,6‐trimethylbenzene with 2‐pyridone

Asha

Rahini

Daisy

et al. 2021

J of Physical Organic Chem

View full text Add to dashboard Cite

show abstract

The combined effect of zinc oxide nanoparticles and milrinone on acute renal ischemia/reperfusion injury in rats: Potential underlying mechanisms

et al. 2023

View full text Add to dashboard Cite

The role of phosphodiesterase 9A inhibitors in heart failure

Foroshani,

Karp,

Aronow

et al. 2024

Expert Opinion on Investigational Drugs

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Phosphodiesterase-III inhibitors amrinone and milrinone on epilepsy and cardiovascular activities

Cited by 6 publications

References 37 publications

Experimental and theoretical studies of 1,3,5‐tris (bromomethyl)‐2,4,6‐trimethylbenzene with 2‐pyridone

Experimental and theoretical studies of 1,3,5‐tris (bromomethyl)‐2,4,6‐trimethylbenzene with 2‐pyridone

The combined effect of zinc oxide nanoparticles and milrinone on acute renal ischemia/reperfusion injury in rats: Potential underlying mechanisms

The role of phosphodiesterase 9A inhibitors in heart failure

Contact Info

Product

Resources

About