Phosphodiesterase inhibitors block the acceleration of skin permeability barrier repair by red light

Goto, Makiko; Ikeyama, Kazuyuki; Tsutsumi, Moe; Denda, Sumiko; Denda, Mitsuhiro

doi:10.1111/j.1600-0625.2011.01255.x

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…In retina, transducin and phosphodiesterase 6 play key roles in signal transmission. Thus, we hypothesized that these proteins might exist in epidermal keratinocytes and be associated with barrier homeostasis (Goto 2011). Immunohistochemical study and reverse transcription-PCR assays confirmed the expression of both transducin and phosphodiesterase 6 in epidermal keratinocytes.…”

Section: Visible Lightmentioning

confidence: 96%

Physical and Chemical Factors that Improve Epidermal Permeability Barrier Homeostasis

Denda¹

2012

Atopic Dermatitis - Disease Etiology and Clinical Management

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Section: Visible Lightmentioning

confidence: 96%

Physical and Chemical Factors that Improve Epidermal Permeability Barrier Homeostasis

Denda¹

2012

Atopic Dermatitis - Disease Etiology and Clinical Management

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“…In addition to these more ‘traditional’ downstream cascades, new intriguing insights are emerging in the literature. Interestingly, red light has been reported to induce rhodopsin‐mediated, phosphodiesterase‐dependent recovery of skin barrier function . In contrast, violet light of 410 nm suppresses human epidermal keratinocyte differentiation by the activation of rhodopsin, probably involving specific signalling pathways via

G_{{italicα}_{i}}

.…”

Section: Multiple Downstream Biomolecular Reactions Explaining Physiomentioning

confidence: 99%

Photobiomodulation devices for hair regrowth and wound healing: a therapy full of promise but a literature full of confusion

Mignon

Botchkareva

Uzunbajakava

et al. 2016

Experimental Dermatology

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Photobiomodulation is reported to positively influence hair regrowth, wound healing, skin rejuvenation and psoriasis. Despite rapid translation of this science to commercial therapeutic solutions, significant gaps in our understanding of the underlying processes remain. The aim of this review was to seek greater clarity and rationality specifically for the selection of optical parameters for studies on hair regrowth and wound healing. Our investigation of 90 reports published between 1985 and 2015 revealed major inconsistencies in optical parameters selected for clinical applications. Moreover, poorly understood photoreceptors expressed in skin such as cytochrome c oxidase, cryptochromes, opsins etc. may trigger different molecular mechanisms. All this could explain the plethora of reported physiological effects of light. To derive parameters for optimal clinical efficacy of photobiomodulation, we recommend a more rational approach to underpin clinical studies, with research on molecular targets and pathways using well-defined biological model systems to enable translation of optical parameters from in vitro to in vivo. Furthermore, special attention needs to be paid when conducting studies for hair regrowth, aiming for double-blind, placebocontrolled randomized clinical trials as the gold standard for quantifying hair growth.

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“…Red-light-induced acceleration of the barrier recovery was blocked by a phosphodiesterase-6 inhibitor. 93 These results suggest that the photoreceptors and signal transmission system present in the retina are also functionally expressed in epidermal keratinocytes.…”

Section: Visible Radiationmentioning

confidence: 87%

Do epidermal keratinocytes have sensory and information processing systems?

Denda

Nakanishi²

2021

Experimental Dermatology

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Epidermal keratinocytes are well known to form a water-impermeable membrane, the stratum corneum, as a physical protective barrier at the surface of the skin. In contrast, studies on cutaneous sensation, for example, tactile sensation or temperature sensation, have focused on the role of nerve terminals or nerve fibres in the skin. However, in the past two decades, sensory functions of keratinocytes for many kinds of environment factors have been discovered. In addition, it has been found that keratinocytes express neurotransmitters and their receptors. These discoveries have dramatically changed our understanding of the role of the epidermis in human skin. Here, we review the sensory and information processing capabilities of keratinocytes, and we discuss the possible role of the epidermis from the standpoint of vertebrate evolution. We suggest that epidermal keratinocytes influence the physical and emotional health of the whole body. | BACKG ROU N DWe have shown that a variety of physical and chemical factors influence epidermal water-impermeable barrier homeostasis. 1 Furthermore, it was reported that the epidermal Ca gradient regulates intracellular Ca distribution and plays a key role in maintaining the barrier function. 2,3 Based on these reports, we searched for corresponding receptors in keratinocytes, and identified a variety of receptors that were originally found in sensory organs and the nervous system, including the brain. 1 Moreover, many other sensory

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Phosphodiesterase inhibitors block the acceleration of skin permeability barrier repair by red light

Cited by 8 publications

References 18 publications

Physical and Chemical Factors that Improve Epidermal Permeability Barrier Homeostasis

Physical and Chemical Factors that Improve Epidermal Permeability Barrier Homeostasis

Photobiomodulation devices for hair regrowth and wound healing: a therapy full of promise but a literature full of confusion

Do epidermal keratinocytes have sensory and information processing systems?

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