Phosphodiesterase inhibitors in vascular ischemia: A case report and review of their use in ischemic conditions

Ng, Wendy KY; Rosenblatt, Yishai

doi:10.4172/plastic-surgery.1000645

CAN J PLAST SURG

2010

DOI: 10.4172/plastic-surgery.1000645

|View full text |Cite

Phosphodiesterase inhibitors in vascular ischemia: A case report and review of their use in ischemic conditions

Wendy KY Ng¹,

Yishai Rosenblatt²

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Determination of molecular pathways and gene ontology of genes associated with Raynaud’s phenomenon

Öztan

2024

Turkish Journal of Biochemistry

View full text Add to dashboard Cite

Objectives Raynaud’s phenomenon (RF) is a disease that causes discoloration of the fingers. The purpose of this study is to identify the molecular pathways in which genes related to RP illness are involved, as well as uncover the biological processes and molecular functions connected with those genes via the use of gene ontology (GO) analysis. Methods Genes associated with RP in the MalaCards Human Diseases database were detected. Twenty genes obtained from the MalaCards Human Diseases database were included in the study for gene ontology analysis via the STRING database. Accordingly, possible interactions between 20 genes were determined through STRING and network enrichment was performed. Results A significant enrichment by gene ontology enrichment analysis was detected in a subset of genes involved in biological processes including cellular response to luteinizing hormone stimulus, negative regulation of fibrinolysis, negative regulation of smooth muscle cell apoptotic process, plasminogen activation, cellular response to follicle-stimulating hormone stimulus. The assay for molecular function determined enrichment of a subset of genes in chemoattractant activity, growth factor activity, heparin binding, sulfur compound binding, growth factor receptor binding. Through the use of KEGG pathways, we were able to identify many molecular processes that contribute to RP, including the AGE-RAGE signaling pathway in diabetic complications, complement and coagulation cascades, fluid shear stress, atherosclerosis. Conclusions Some individuals may have a genetic predisposition to the onset of Raynaud’s phenomenon. Our data showed that it is associated with genes involved in vascular damage and fibrosis, especially in RP. Therefore, we can include RP disease in the group of vascular diseases.

show abstract

Determination of molecular pathways and gene ontology of genes associated with Raynaud’s phenomenon

Öztan

2024

Turkish Journal of Biochemistry

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Phosphodiesterase inhibitors in vascular ischemia: A case report and review of their use in ischemic conditions

Cited by 1 publication

References 22 publications

Determination of molecular pathways and gene ontology of genes associated with Raynaud’s phenomenon

Determination of molecular pathways and gene ontology of genes associated with Raynaud’s phenomenon

Contact Info

Product

Resources

About