1999
DOI: 10.1074/jbc.274.14.9129
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Phosphoinositide 3-Kinases and Their FYVE Domain-containing Effectors as Regulators of Vacuolar/Lysosomal Membrane Trafficking Pathways

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Cited by 228 publications
(167 citation statements)
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“…In addition, previous studies have identified proteins required for vesicular trafficking processes that contain a segment known as a FYVE domain (21). FYVE domains are zinc finger-like domains that specifically bind to PI(3)P, acting as targeting motifs to direct proteins to specific sites within the cell (14,21,(23)(24)(25). Myotubularin may act to regulate the subcellular localization of proteins containing FYVE domains by controlling cellular levels of their target lipid, PI(3)P, thus affecting specific signaling pathways dependent on these effectors.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In addition, previous studies have identified proteins required for vesicular trafficking processes that contain a segment known as a FYVE domain (21). FYVE domains are zinc finger-like domains that specifically bind to PI(3)P, acting as targeting motifs to direct proteins to specific sites within the cell (14,21,(23)(24)(25). Myotubularin may act to regulate the subcellular localization of proteins containing FYVE domains by controlling cellular levels of their target lipid, PI(3)P, thus affecting specific signaling pathways dependent on these effectors.…”
Section: Discussionmentioning
confidence: 99%
“…We demonstrate here that myotubularin dephosphorylates the lipid second messenger, PI(3)P, in vitro and in vivo. Although present at relatively low levels in eukaryotic cells, PI(3)P has been shown to play a key role in membrane trafficking͞vesicular transport processes and serves as a targeting mechanism for proteins containing a specific PI(3)P-binding motif known as a FYVE domain (21)(22)(23)(24)(25). Myotubularin phosphatase activity is highly specific toward PI(3)P, and MTM1 mutations that cause myotubular myopathy render the enzyme catalytically inactive, suggesting a direct link between myotubular myopathy and PI(3)P levels.…”
mentioning
confidence: 99%
“…Genetic studies performed in yeast have demonstrated that PtdIns3P plays an important role in regulating Golgi-to-vacuole or Golgi-to-lysosome membrane trafficking, as well as endosome function [33]. Several proteins (e.g.…”
Section: Figure 6 Amino Acid Sequence and Tissue Distribution Of Pepp1mentioning
confidence: 99%
“…If the effect of the reduction of PtdIns(4)P level caused by sec14 and pik1 mutations is specific for the production of Golgi-derived vesicles destined for the plasma membrane, then these mutations should have little or no effect on the delivery of products to the vacuole. Indeed, sec14 mutations have minimal effects on the sorting of proteins to the vacuole (43) 3 ; and, conversely, there is strong evidence that Vps34p-dependent PtdIns(3)P production is critical for the delivery of vacuolar hydrolases to the vacuole (44). Given the effect of pik1 mutations on PtdIns(4)P formation and on secretion of invertase, it was of interest to test the effect of these mutations on the transport of a vacuolar constituent.…”
Section: Delivery Of Cpy To the Vacuole Is Not Blocked In Pik1 Tsmentioning
confidence: 99%