Phospholipase A2

Comparative Analysis of Human Hepatic Lesions in Dengue, Yellow Fever, and Chikungunya: Revisiting Histopathological Changes in the Light of Modern Knowledge of Cell Pathology

“…Although data on hepatic fatty degeneration in CF are scarce, flavivirus and alphavirus infections have lipid metabolic implications that influence the immune response against infection and the maintenance of viral pathogenic mechanisms [ 47 ]. In addition, studies have reported that the synthesis of lipid mediators during viral infection is related to the signalling, control, and maintenance of the immune response and viral pathogenesis [ 66 , 67 , 68 , 69 , 70 ]. During infection, the virus can control the lipid metabolism of the host cell to meet the demands of the viral replication process, as the mobilisation and recruitment of lipid droplets is an essential mechanism in the bioenergetic demand for viral proliferation, which occurs through the formation of replication complexes in regions of high lipid concentration.…”

β-Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit β-Cell Apoptosis

“…1,[13][14][15] The majority of these inhibitors have been developed to target cytosolic GIVA cPLA 2 16 and secreted sPLA 2 . 17 Inhibitors of GVIA iPLA 2 had attracted less interest, because the enzyme's role was less well understood. The first introduced inhibitor for iPLA 2 was a bromoenol lactone compound (1, BEL, 18 Figure 1) which is an irreversible, covalent inhibitor of GVIA iPLA 2 .…”