Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity

Liu, Zhongshun; Jiang, Congwei; Lei, Zhangmengxue; Dong, Sihan; Kuang, Linlin; Huang, Chenxu; Gao, Ying; Mu, Lei; Xiao, Hui; Legembre, Patrick; Jung, Jae U.; Liang, Huaping; Liang, Xiaozhen

doi:10.1073/pnas.2111115119

Cited by 6 publications

(2 citation statements)

References 50 publications

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“…PINLYP may similarly influence breeding behavior and/or fecundity related to drought conditions, because it is also associated with groundwater recharge. The gene inhibits phospholipase A2, known to influence oocyte activation in an Argentinean species of toad (Ajmat et al, 2013 ), and may also be critical to innate immunity required for normal embryonic development (Liu et al, 2022 ). KIF1C is relatively unstudied in amphibians, but follows the same environmental pattern as PINLYP, and other kinesin‐like proteins are known to influence amphibian embryonic development (Robb et al, 1996 ).…”

Section: Discussionmentioning

confidence: 99%

Using landscape genomics to delineate future adaptive potential for climate change in the Yosemite toad (Anaxyrus canorus)

Maier

Vandergast

Bohonak

2022

Evolutionary Applications

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An essential goal in conservation biology is delineating population units that maximize the probability of species persisting into the future and adapting to future environmental change. However, future‐facing conservation concerns are often addressed using retrospective patterns that could be irrelevant. We recommend a novel landscape genomics framework for delineating future “Geminate Evolutionary Units” (GEUs) in a focal species: (1) identify loci under environmental selection, (2) model and map adaptive conservation units that may spawn future lineages, (3) forecast relative selection pressures on each future lineage, and (4) estimate their fitness and likelihood of persistence using geo‐genomic simulations. Using this process, we delineated conservation units for the Yosemite toad ( Anaxyrus canorus ), a U.S. federally threatened species that is highly vulnerable to climate change. We used a genome‐wide dataset, redundancy analysis, and Bayesian association methods to identify 24 candidate loci responding to climatic selection ( R 2 ranging from 0.09 to 0.52), after controlling for demographic structure. Candidate loci included genes such as MAP3K5, involved in cellular response to environmental change. We then forecasted future genomic response to climate change using the multivariate machine learning algorithm Gradient Forests. Based on all available evidence, we found three GEUs in Yosemite National Park, reflecting contrasting adaptive optima: YF‐North (high winter snowpack with moderate summer rainfall), YF‐East (low to moderate snowpack with high summer rainfall), and YF‐Low‐Elevation (low snowpack and rainfall). Simulations under the RCP 8.5 climate change scenario suggest that the species will decline by 29% over 90 years, but the highly diverse YF‐East lineage will be least impacted for two reasons: (1) geographically it will be sheltered from the largest climatic selection pressures, and (2) its standing genetic diversity will promote a faster adaptive response. Our approach provides a comprehensive strategy for protecting imperiled non‐model species with genomic data alone and has wide applicability to other declining species.

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Section: Discussionmentioning

confidence: 99%

Using landscape genomics to delineate future adaptive potential for climate change in the Yosemite toad (Anaxyrus canorus)

Maier

Vandergast

Bohonak

2022

Evolutionary Applications

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“…Could Ly6 proteins also modulate the function of such a diverse array of receptors? Current work has identified only a few non-nicotinic acetylcholine receptor targets for Ly6 proteins, including the Shaker-type potassium channels [ 27 ], CD3ζ chains of the T cell receptor signaling complex (TCR) [ 28 ], TBK1 [ 29 ], and EGFR/PDGFR heterodimer [ 30 ]. This work demonstrates that Ly6 proteins can modulate the function of non-nicotinic acetylcholine receptors, opening up possibilities of identifying other novel targets of Ly6-mediated regulation.…”

Section: Introductionmentioning

confidence: 99%

GluR2Q and GluR2R AMPA Subunits are not Targets of lypd2 Interaction

2022

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A large family of prototoxin-like molecules endogenous to mammals, Ly6 proteins have been implicated in the regulation of cell signaling processes across multiple species. Previous work has shown that certain members of the Ly6 family are expressed in the brain and target nicotinic acetylcholine receptor and potassium channel function. Structural similarities between Ly6 proteins and alpha-neurotoxins suggest the possibility of additional ionotropic receptor targets. Here, we investigated the possibility of lypd2 as a novel regulator of AMPA receptor (AMPAR) function. In particular, we focused on potential interactions with the Q/R isoforms of the GluR2 subunit, which have profound impacts on AMPAR permeability to calcium during neuronal stimulation. We find that although lypd2 and GluR2 share overlapping expression patterns in the mouse hippocampus, there was no interaction between lypd2 and either GluR2Q or GluR2R isoform. These results underscore the importance of continuing to investigate novel targets for Ly6 interaction and regulation.

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The GPIHBP1-LPL complex and its role in plasma triglyceride metabolism: Insights into chylomicronemia

Jiang,

Ren,

Yang

et al. 2023

Biomedicine & Pharmacotherapy

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Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity

Cited by 6 publications

References 50 publications

Using landscape genomics to delineate future adaptive potential for climate change in the Yosemite toad (Anaxyrus canorus)

Using landscape genomics to delineate future adaptive potential for climate change in the Yosemite toad (Anaxyrus canorus)

GluR2Q and GluR2R AMPA Subunits are not Targets of lypd2 Interaction

The GPIHBP1-LPL complex and its role in plasma triglyceride metabolism: Insights into chylomicronemia

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