Phospholipase C-related catalytically inactive protein: A novel signaling molecule for modulating fat metabolism and energy expenditure

Kanematsu, Takashi; Oue, Kana; Okumura, Takahiro; Harada, Kae; Yamawaki, Yosuke; Asano, Shigetaka; Mizokami, Akinari; Irifune, Masahiro; Hirata, Masato

doi:10.1016/j.job.2019.04.002

Cited by 9 publications

(4 citation statements)

References 62 publications

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“…In particular, brown adipose tissue is important for metabolic heat production through non‐shivering thermogenesis under cold conditions (Cannon & Nedergaard, 2004 ; Klaus et al., 1988 ). Two candidate genes associated with lipid metabolism are therefore of particular interest: PRIP , which encodes an enzyme that modulates lipid metabolism and serves as a signalling molecule for non‐shivering thermogenesis (Kanematsu et al., 2019 ; Oue et al., 2016 ), and LRRC8C , which encodes a structural component of the volume‐regulated anion channel in adipocytes and is associated with the early phase of adipocyte differentiation and diet‐induced obesity (Hayashi et al., 2011 ; Tominaga et al., 2004 ).…”

Section: Discussionmentioning

confidence: 99%

Genomic signatures of climate adaptation in bank voles

Folkertsma,

Charbonnel,

Henttonen

et al. 2024

Ecology and Evolution

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Evidence for divergent selection and adaptive variation across the landscape can provide insight into a species' ability to adapt to different environments. However, despite recent advances in genomics, it remains difficult to detect the footprints of climate‐mediated selection in natural populations. Here, we analysed ddRAD sequencing data (21,892 SNPs) in conjunction with geographic climate variation to search for signatures of adaptive differentiation in twelve populations of the bank vole (Clethrionomys glareolus) distributed across Europe. To identify the loci subject to selection associated with climate variation, we applied multiple genotype‐environment association methods, two univariate and one multivariate, and controlled for the effect of population structure. In total, we identified 213 candidate loci for adaptation, 74 of which were located within genes. In particular, we identified signatures of selection in candidate genes with functions related to lipid metabolism and the immune system. Using the results of redundancy analysis, we demonstrated that population history and climate have joint effects on the genetic variation in the pan‐European metapopulation. Furthermore, by examining only candidate loci, we found that annual mean temperature is an important factor shaping adaptive genetic variation in the bank vole. By combining landscape genomic approaches, our study sheds light on genome‐wide adaptive differentiation and the spatial distribution of variants underlying adaptive variation influenced by local climate in bank voles.

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Section: Discussionmentioning

confidence: 99%

Genomic signatures of climate adaptation in bank voles

Folkertsma,

Charbonnel,

Henttonen

et al. 2024

Ecology and Evolution

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show abstract

“…In particular, brown adipose tissue is important for metabolic heat production through non-shivering thermogenesis under cold conditions (Cannon & Nedergaard, 2004;Klaus et al, 1988). Two candidate genes associated with lipid metabolism are therefore of particular interest: PRIP, which encodes an enzyme that modulates lipid metabolism and serves as a signalling molecule for non-shivering thermogenesis (Kanematsu et al, 2019;Oue et al, 2016), and LRRC8C, which encodes a structural component of the volume-regulated anion channel in adipocytes and is associated with the early phase of adipocyte differentiation and diet-induced obesity (Hayashi et al, 2011;Tominaga et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Genomic signatures of climate adaptation in bank voles

Folkertsma

Charbonnel

Henttonen

et al. 2023

Preprint

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Evidence for spatially varying selection and adaptive variation can provide insight into a species’ ability to adapt to different environments. However, despite recent advances in genomics, it remains difficult to detect footprints of spatially varying selection in natural populations. Here we analysed ddRAD sequencing data (21,892 SNPs) in conjunction with geographic climate variation to search for signatures of adaptive differentiation in twelve populations of the bank vole (Myodes/Clethrionomys glareolus) distributed across Europe. To identify the loci subject to spatially varying selection and associated with climate variation, we applied multiple genotype-environment association (GEA) methods, two univariate and one multivariate, and controlled for the effect of population structure. In total, we identified 213 candidate adaptive loci, 74 of which were located within genes. In particular, we identified signatures of selection in candidate genes with functions related to lipid metabolism and the immune system. Using the results of redundancy analysis (RDA), we demonstrated that population history and climate have joint effects on the genetic variation in the pan-European metapopulation. Furthermore, by examining only candidate loci, we found that annual mean temperature is an important factor shaping adaptive genetic variation in the bank vole. By combining landscape genomic approaches, our study sheds light on genome-wide adaptive differentiation and the spatial distribution of variants underlying adaptive variation in bank voles that are influenced by local climate.

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“…For example, PLCB2 (phospholipase C beta 2) was specific expressed in the BL group. Phospholipase C is a class of glycerol phospholipid hydrolases, hydrolyzing the glycerol phosphate C3 site [ 50 ]. The protein encoded by PLCB2 is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4, 5-bisphosphate to the secondary messengers inositol 1, 4, 5-trisphosphate (IP3) and diacylglycerol.…”

Section: Discussionmentioning

confidence: 99%

Identification of Long Non-Coding RNAs Involved in Porcine Fat Deposition Using Two High-Throughput Sequencing Methods

Liu

Hong

et al. 2021

Genes

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Adipose is an important body tissue in pigs, and fatty traits are critical in pig production. The function of long non-coding RNA (lncRNA) in fat deposition and metabolism has been found in previous studies. In this study, we collected the adipose tissue of six Landrace pigs with contrast backfat thickness (nhigh = 3, nlow = 3), after which we performed strand-specific RNA sequencing (RNA-seq) based on pooling and biological replicate methods. Biological replicate and pooling RNA-seq revealed 1870 and 1618 lncRNAs, respectively. Using edgeR, we determined that 1512 genes and 220 lncRNAs, 2240 genes and 127 lncRNAs were differentially expressed in biological replicate and pooling RNA-seq, respectively. After target gene prediction, we found that ACSL3 was cis-targeted by lncRNA TCONS-00052400 and could activate the conversion of long-chain fatty acids. In addition, lncRNA TCONS_00041740 cis-regulated gene ACACB regulated the rate-limiting enzyme in fatty acid oxidation. Since these genes have necessary functions in fat metabolism, the results imply that the lncRNAs detected in our study may affect backfat deposition in swine through regulation of their target genes. Our study explored the regulation of lncRNA and their target genes in porcine backfat deposition and provided new insights for further investigation of the biological functions of lncRNA.

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Phospholipase C-related catalytically inactive protein: A novel signaling molecule for modulating fat metabolism and energy expenditure

Cited by 9 publications

References 62 publications

Genomic signatures of climate adaptation in bank voles

Genomic signatures of climate adaptation in bank voles

Genomic signatures of climate adaptation in bank voles

Identification of Long Non-Coding RNAs Involved in Porcine Fat Deposition Using Two High-Throughput Sequencing Methods

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