2023
DOI: 10.3390/vetsci10120698
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Phospholipase C Zeta 1 (PLCZ1): The Function and Potential for Fertility Assessment and In Vitro Embryo Production in Cattle and Horses

Raul A. Gonzalez-Castro,
Elaine M. Carnevale

Abstract: Phospholipase C Zeta 1 (PLCZ1) is considered a major sperm-borne oocyte activation factor. After gamete fusion, PLCZ1 triggers calcium oscillations in the oocyte, resulting in oocyte activation. In assisted fertilization, oocyte activation failure is a major cause of low fertility. Most cases of oocyte activation failures in humans related to male infertility are associated with gene mutations and/or altered PLCZ1. Consequently, PLCZ1 evaluation could be an effective diagnostic marker and predictor of sperm fe… Show more

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Cited by 3 publications
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“…Sperm PLCζ amount exhibits a large variation from stallion to stallion which can influence fertility outcomes. Stallion sperm samples showing low PLCζ consistently result in lower fertility after ICSI ( Gonzalez-Castro and Carnevale, 2023 ).…”
Section: Discussionmentioning
confidence: 99%
“…Sperm PLCζ amount exhibits a large variation from stallion to stallion which can influence fertility outcomes. Stallion sperm samples showing low PLCζ consistently result in lower fertility after ICSI ( Gonzalez-Castro and Carnevale, 2023 ).…”
Section: Discussionmentioning
confidence: 99%