PhospholipaseA₂Inhibitors of Marine Origin

Synthesis of γ-hydroxy-γ-perfluoroalkyl butenolides and exocyclic double bond butanolides via regioselective allylic alkylations of MBH carbonates with 2-perfluoroalkyl-oxazol-5(2H)-ones

“…1, IV–VI ), are widely present in bioactive compounds, natural products, drug candidates, and materials. 1 Ianthellidone G ( I ), a candidate of BACE inhibitors, was isolated from a southern Australian marinesponge, ianthella sp. 2 Strchnistenolide A ( II ) was obtained from the root of Lindera strychnifolia , which has an inhibitory effect on nitric oxide production in RAW 264.7 cells.…”

Catalyst-Controlled Regioselective Nitrosocarbonyl Aldol Reaction of Deconjugated Butenolides

“…Butenolide and derivatives thereof, particularly with γ-hydroxy functionality, are recurring motifs in natural products, bioactive compounds, and drug candidates. , Some prominent examples include hs PLA 2 inhibitor cacospongionolide E, antifungal compound pseudomonas aureofaciens strain, and Cdc25A inhibitor dysidiolide (Scheme a) . They also serve as valuable synthetic intermediates to build molecular complexity. , Consequently, devising streamlined synthetic strategies for the fabrication of butenolide scaffolds remains in the limelight of organic synthesis.…”