Phospholipases of <i>Candida albicans</i>

Niewerth, M.; Körting, Hans Christian

doi:10.1046/j.1439-0507.2001.00685.x

Cited by 70 publications

(23 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The family of phospholipases consists of four different classes (A, B, C and D) 71 . Only the five members of class B ( PLB1–5 ) are extracellular and may contribute to pathogenicity via disruption of host membranes 72 .…”

Section: Pathogenicity Mechanismsmentioning

confidence: 99%

Candida albicanspathogenicity mechanisms

2013

View full text Add to dashboard Cite

The polymorphic fungus Candida albicans is a member of the normal human microbiome. In most individuals, C. albicans resides as a lifelong, harmless commensal. Under certain circumstances, however, C. albicans can cause infections that range from superficial infections of the skin to life-threatening systemic infections. Several factors and activities have been identified which contribute to the pathogenic potential of this fungus. Among them are molecules which mediate adhesion to and invasion into host cells, the secretion of hydrolases, the yeast-to-hypha transition, contact sensing and thigmotropism, biofilm formation, phenotypic switching and a range of fitness attributes. Our understanding of when and how these mechanisms and factors contribute to infection has significantly increased during the last years. In addition, novel virulence mechanisms have recently been discovered. In this review we present an update on our current understanding of the pathogenicity mechanisms of this important human pathogen.

show abstract

Section: Pathogenicity Mechanismsmentioning

confidence: 99%

Candida albicanspathogenicity mechanisms

2013

View full text Add to dashboard Cite

show abstract

“…The alteration of immune response is not unique to bacteria, but plays a significant role as a virulence factor during C. albicans infection. Candida albicans is able to metabolize AA, liberated from host cells by host as well as yeast-derived phospholipase A 2 (Castro et al, 1994 ; Filler et al, 1994 ; Brash, 2001 ; Niewerth and Korting, 2001 ; Theiss et al, 2006 ; Parti et al, 2010 ). In addition, C. albicans can induce significant production of PGE 2 by mammalian cells (Filler et al, 1994 ; Deva et al, 2001 ).…”

Section: Production and Role Of Oxylipins During Infectionmentioning

confidence: 99%

Candida albicans and Pseudomonas aeruginosa Interaction, with Focus on the Role of Eicosanoids

et al. 2016

View full text Add to dashboard Cite

Candida albicans is commonly found in mixed infections with Pseudomonas aeruginosa, especially in the lungs of cystic fibrosis (CF) patients. Both of these opportunistic pathogens are able to form resistant biofilms and frequently infect immunocompromised individuals. The interaction between these two pathogens, which includes physical interaction as well as secreted factors, is mainly antagonistic. In addition, research suggests considerable interaction with their host, especially with immunomodulatory lipid mediators, termed eicosanoids. Candida albicans and Pseudomonas aeruginosa are both able to utilize arachidonic acid (AA), liberated from the host cells during infection, to form eicosanoids. The production of these eicosanoids, such as Prostaglandin E2, by the host and the pathogens may affect the dynamics of polymicrobial infection and the outcome of infections. It is of considerable importance to elucidate the role of host-produced, as well as pathogen-produced eicosanoids in polymicrobial infection. This review will focus on in vitro as well as in vivo interaction between C. albicans and P. aeruginosa, paying special attention to the role of eicosanoids in the cross-talk between host and the pathogens.

show abstract

“…Another family of Candida virulence enzymes are the phospholipases, which consist of four different classes (PLB-A, PLB-B, PLB-C, and PLB-D) [61]. However, only five members of class B ( PLB1-5 ) are extracellular and may contribute to pathogenicity.…”

Section: Pathogenesis Of Candida Albicansmentioning

confidence: 99%

Dissecting Candida albicans Infection from the Perspective of C. albicans Virulence and Omics Approaches on Host–Pathogen Interaction: A Review

Chin

Lee

Basir

et al. 2016

IJMS

View full text Add to dashboard Cite

Candida bloodstream infections remain the most frequent life-threatening fungal disease, with Candida albicans accounting for 70% to 80% of the Candida isolates recovered from infected patients. In nature, Candida species are part of the normal commensal flora in mammalian hosts. However, they can transform into pathogens once the host immune system is weakened or breached. More recently, mortality attributed to Candida infections has continued to increase due to both inherent and acquired drug resistance in Candida, the inefficacy of the available antifungal drugs, tedious diagnostic procedures, and a rising number of immunocompromised patients. Adoption of animal models, viz. minihosts, mice, and zebrafish, has brought us closer to unraveling the pathogenesis and complexity of Candida infection in human hosts, leading towards the discovery of biomarkers and identification of potential therapeutic agents. In addition, the advancement of omics technologies offers a holistic view of the Candida-host interaction in a non-targeted and non-biased manner. Hence, in this review, we seek to summarize past and present milestone findings on C. albicans virulence, adoption of animal models in the study of C. albicans infection, and the application of omics technologies in the study of Candida–host interaction. A profound understanding of the interaction between host defense and pathogenesis is imperative for better design of novel immunotherapeutic strategies in future.

show abstract

Phospholipases of Candida albicans

Cited by 70 publications

References 29 publications

Candida albicanspathogenicity mechanisms

Candida albicanspathogenicity mechanisms

Candida albicans and Pseudomonas aeruginosa Interaction, with Focus on the Role of Eicosanoids

Dissecting Candida albicans Infection from the Perspective of C. albicans Virulence and Omics Approaches on Host–Pathogen Interaction: A Review

Contact Info

Product

Resources

About