Phospholipid and Fatty Acid Metabolism in Schizophrenia and Depression

Serum Ghrelin and Cholesterol Values in Suicide Attempters

“…Moreover, phospholipase A 2 and fatty acid coenzyme A ligase 4, which are involved in lipid metabolism, are 2 key enzymes involved in signal transduction processes following the activation of various receptors, e.g. 5-HT 2 , which may be involved in the pathophysiology of both violence and suicide attempts [27] . Fasting ghrelin levels have been found to correlate most strongly with insulin and cholesterol levels [28] , which has been supported by this study.…”

The Use of 31-Phosphorus Magnetic Resonance Spectroscopy to Study Brain Cell Membrane Motion- Restricted Phospholipids

“…They tend to point to reduced erythrocyte membrane levels of the long-chain polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid, in the context of a biphasic distribution with one group of schizophrenia patients having essentially normal fatty acid levels, while the other has significantly low levels . It is of particular interest to note that when the schizophrenia patients were divided into those with predominantly negative symptoms, such as affective flattening, and predominantly positive syndromes, including positive symptoms such as auditory hallucinations and thought disorder, the low erythrocyte membrane levels of arachidonic acid and docosahexaenoic acid were largely confined to patients with a negative syndrome (Horrobin, 2003).…”