Phospholipid changes in Rhinella arenarum embryos under different acclimation conditions to copper

Fonovich, Teresa Mabel; Pérez-Coll, Cristina S.; Fridman, Osvaldo; D'Eramo, José L.; Herkovits, Jorge

doi:10.1016/j.cbpc.2016.06.007

Cited by 6 publications

(2 citation statements)

References 54 publications

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“…The integration of the main markers in heavily vs. moderately contaminated fish allowed to hypothesise a relationship between the levels of sphingomyelin-phosphatidylserine-free sterols, and the fish capacity to manage the oxidative stress and to metabolize xenobiotics. Finally, we suggest that phospholipid metabolism changes could be relevant markers in ecotoxicology [89,90]. Specifically, their combination with biomarkers of energy metabolism and oxidative stress could elucidate the pathways and mechanisms in xenobiotic acclimation and resilience.…”

Section: Discussionmentioning

confidence: 94%

An Integrated Biomarker Approach Using Flounder to Improve Chemical Risk Assessments in the Heavily Polluted Seine Estuary

Borcier

Charrier

Couteau³

et al. 2020

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The objective of this study was to develop an integrative approach in ecotoxicology (from biomarkers to population genetics) to assess the ecological status of fish populations. Flounders (Platichthys flesus) collected after the spawning season in the heavily polluted Seine estuary were compared with the moderately polluted Bay of Douarnenez. The muscle energetic reserves were highly depleted in Seine vs. Douarnenez fish. The Seine fish displaying a reduced capacity to manage the oxidative stress and a higher energetic metabolism. An increase in the content of muscle membrane phospholipids (sphingomyelin, phosphatidylserine, free sterols) was detected in the Seine vs. Douarnenez fish. The data integration allowed to hypothesize relationships between membrane phospholipids, xenobiotic metabolism, bioenergetics, and antioxidant defence. The genetic diversity considering neutral markers was maintained in the heavily polluted Seine population compared with the Douarnenez population. Finally, we suggest that the high physiological cost of tolerance to toxicants in the Seine flounder population could compromise its capacity to respond in the future to an additional stressor like warming waters in shallow depth. Thus, this population could be submitted to an ecological risk.

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Section: Discussionmentioning

confidence: 94%

An Integrated Biomarker Approach Using Flounder to Improve Chemical Risk Assessments in the Heavily Polluted Seine Estuary

Borcier

Charrier

Couteau³

et al. 2020

JoX

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“…Amphibian embryos, used as unique models for studies of damage caused by various toxicants, vividly reveal the consequences of subcellular processes triggered by exposure to the toxicant. As the embryo develops, these hidden changes quickly manifest themselves as malformations, changes in the rate of embryogenesis or termination of embryogenesis, or mortality (Chen et al, 2007;Xia et al, 2012;Lance et al, 2012Lance et al, , 2013Flynn et al, 2015;Fonovich et al, 2016). Examination of the influence of high concentrations of copper ions on the early development of amphibians can help elucidate its acute toxic effects and estimate the resistance of early stages of embryonic development to such effects.…”

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confidence: 99%

Effects of High Copper Exposure on Development and Survival During Early Ontogenesis in the Common Toad

2018

Preprint

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Exposure to environmental pollutants contributes to the global decline of amphibians. Amphibian embryos are unique models for studying the effects of various toxic agents on developmental processes. Some of the most detrimental toxic agents are heavy metals, the study of which is a priority in ecotoxicology. Copper is a microelement required in many biological systems, but it can be toxic at concentrations higher than normal physiological range. The purpose of the present study was to analyze the toxic effect of high concentrations of Cu (10, 25, and 50 mg/L) on Bufo bufo embryos. The present study shows that short-term (48 h) toxicity test can fail to register toxicological effect of Cu, whereas long-term toxicity test demonstrates that all analyzed concentrations are lethal to common toad embryos. Early stages of development (stages 4-8, Gosner 1960) are shown to be rather tolerant to copper, even at high concentrations. Effects of copper begin to manifest themselves at the blastula stage (stages 8-9, Gosner, 1960). The present study also shows that initial egg density affects copper-related mortality rate of embryos. If egg density is high, copper-related mortality rate is sometimes decreased, possibly because jelly coats of eggs bind great amounts of dissolved copper. It is also shown that clutches can differ in sensitivity to different copper concentrations. Taken together, our data demonstrate that the conditions of the experiment (such as the initial egg density) and individual sensitivity of clutches to the toxic agent considerably contribute to the results of the ecotoxicological experiment.

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Native anurans threatened by the alien tree Ligustrum lucidum in a seasonal subtropical forest

2021

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Phospholipid changes in Rhinella arenarum embryos under different acclimation conditions to copper

Cited by 6 publications

References 54 publications

An Integrated Biomarker Approach Using Flounder to Improve Chemical Risk Assessments in the Heavily Polluted Seine Estuary

An Integrated Biomarker Approach Using Flounder to Improve Chemical Risk Assessments in the Heavily Polluted Seine Estuary

Effects of High Copper Exposure on Development and Survival During Early Ontogenesis in the Common Toad

Native anurans threatened by the alien tree Ligustrum lucidum in a seasonal subtropical forest

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