Phospholipid composition of myelin and synaptosomal proteolipid from vertebrate brain

Денисова, Н. А.

doi:10.1016/0020-711x(90)90255-2

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Crude membrane fractions (P-2) were separated from the crude nuclear fractions in each of the brain regions by low speed centrifugation, followed by ultra centrifugation on a Ficoll gradient (7% and 14%) for separation of myelin fractions. The purity of the isolated myelin fractions was confirmed previously by electronmicroscopic and biochemical analyses [37, 38]. Collected myelin fractions were assessed for protein, sulfatide and vitamin K concentrations.…”

Section: Methodsmentioning

confidence: 97%

Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides

Crivello

Casseus

Peterson

et al. 2010

The Journal of Nutritional Biochemistry

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Dysregulation of myelin sulfatides is a risk factor for cognitive decline with age. Vitamin K is present in high concentrations in the brain and has been implicated in the regulation of sulfatide metabolism. Our objective was to investigate the age-related interrelation between dietary vitamin K and sulfatides in myelin fractions isolated from the brain regions of Fischer 344 male rats fed one of two dietary forms of vitamin K: phylloquinone or its hydrogenated form, dihydrophylloquinone for 28 days. Both dietary forms of vitamin K were converted to menaquinone-4 in the brain. The efficiency of dietary dihydrophylloquinone conversion to menaquinone-4 compared to dietary phylloquinone was lower in the striatum and cortex, and was similar to those in the hippocampus. There were significant positive correlations between sulfatides and menaquinone-4 in the hippocampus (phylloquinonesupplemented diet -12mo and 24mo; dihydrophylloquinone -supplemented diet -12mo) and cortex (phylloquinone-supplemented diet -12mo and 24 mo). No significant correlations were observed in the striatum. Furthermore, sulfatides in the hippocampus were significantly positively correlated with MK-4 in serum. This is the first attempt to establish and characterize a novel animal model that exploits the inability of dietary dihydrophylloquinone to convert to brain menaquinone-4 to study the dietary effects of vitamin K on brain sulfatide in brain regions controlling motor and cognitive functions. Our findings suggest that this animal model may be useful for investigation of the effect of the dietary vitamin K on sulfatide metabolism, myelin structure, and behavior functions.

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Section: Methodsmentioning

confidence: 97%

Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides

Crivello

Casseus

Peterson

et al. 2010

The Journal of Nutritional Biochemistry

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“…Of the brain membranes, myelin and neuronal plasma membranes are particularly enriched with sphingolipids. 26,27 Polysialogangliosides, which belong to the gangliosides (a subclass of glycosphingolipids), have several sialic acids in their structure. Polysialogangliosides are the predominant constituents of neuronal plasma membranes, whereas myelin membranes are primarily represented by cerebrosides, sulfatides, and monosialogangliosides (i.e., gangliosides with one sialic acid in their structure).…”

Section: Distribution and Physiological Functionsmentioning

confidence: 99%

Vitamin K and Sphingolipid Metabolism: Evidence to Date

Denisova

Booth

2005

Nutrition Reviews

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The brain is enriched with sphingolipids, which are important membrane constituents and major lipid signaling molecules that have a role in motor and cognitive behavior. Vitamin K has been implicated in brain sphingolipid metabolism for more than 30 years. The in vitro and in vivo studies to date suggest a role of vitamin K in the regulation of multiple enzymes involved in sphingolipid metabolism within the myelin-rich regions in the brain. However, the precise mechanisms of action are not well understood. Further, the physiological consequences of the observed effects of vitamin K on sphingolipid metabolism have not been systematically studied.

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Fatty acid composition of phospholipids of myelin and synaptosomal proteolipid complexes from vertebrate brain

Denisova

Gorbunov

Аврова

1991

International Journal of Biochemistry

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Phospholipid composition of myelin and synaptosomal proteolipid from vertebrate brain

Cited by 5 publications

References 24 publications

Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides

Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides

Vitamin K and Sphingolipid Metabolism: Evidence to Date

Fatty acid composition of phospholipids of myelin and synaptosomal proteolipid complexes from vertebrate brain

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