Phospholipid Metabolism in Rat Intestinal Mucosa After Oral Administration of Lysophospholipids

Bruni, A.; Orlando, Paolo; Mietto, L.; Viola, Giampietro

doi:10.1007/978-1-4615-3426-6_20

Cited by 6 publications

(11 citation statements)

References 16 publications

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“…Seminal work by Bruni et al (1976) confirmed that PtdSer was able to modify endocrine function. These authors showed that injecting mice with PtdSer liposomes promoted increases in brain glucose and blood glucose that were probably associated with the release of catecholamines (Toffano et al, 1976) and histamine from peripheral tissues (Bigon et a l, 1979).…”

Section: Neuroendocrinological Regulationmentioning

confidence: 91%

“…These authors showed that injecting mice with PtdSer liposomes promoted increases in brain glucose and blood glucose that were probably associated with the release of catecholamines (Toffano et al, 1976) and histamine from peripheral tissues (Bigon et a l, 1979). Since this time PtdSer has been demonstrated to influence cortical acetylcholine release (Casamenti et al, 1979;Pepeu et al, 1986;Casamenti et a l, 1991;Yamatoya et al, 2000), dopamine and noradrenaline release (Toffano et a l, 1976), at least following i.v. administration in rodents.…”

Section: Neuroendocrinological Regulationmentioning

confidence: 99%

“…Although not specifically addressed in this study, it is likely that the majority of the PtdSer that interacts with the phospholipid pool of the plasma membrane will be maintained in the inner leaflet o f the plasma membrane while a small proportion will be translocated to the mitochondria and golgi apparatus (Heikinheimo and Somerhaiju, 2002). Bruni et a l (1992) investigated the fate of PtdSer following orally administered PtdSer using duodenal infusion with radioactively labelled PtdSer in rats. Following the determination of radioactivity in the lymph over 5 h, these authors concluded that the majority o f the PtdSer supplement was hydrolysed or converted to other phospholipids (mainly phosphatidylethanolamine and phosphatidylcholine);…”

Section: Fate Of Exogenous Phosphatidylserinementioning

confidence: 99%

“…The addition of PtdSer to mammalian tissues inhibits the production of pro-inflammatory cytokines(Gilbreath et a l, 1986; Aramaki et a l, 1997) and induces anti-inflammatory responses(Huynh et a l, 2002) in in-vitro preparations. In addition, intravenously injected PtdSer has been demonstrated to have an inhibitory effect on the immune response to endotoxin-induced inflammation in rodents (Monastra andBruni, 1992). Although the mechanism(s) by which PtdSer inhibits the immune response remain unclear, recent data suggest that PtdSer inhibits immune responses by acting on cell types (e.g., macrophages, fibroblasts, neutrophils, endothelial cells, epithelial cells) at the site of inflammation(Hoffmann et a l, 2005).…”

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confidence: 99%

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Effects of Phosphatidylserine Supplementation on Exercising Humans

Kingsley

2006

Sports Medicine

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Phosphatidylserine (PtdSer) is a ubiquitous phospholipid species that is normally located within the inner leaflet of the cell membrane. PtdSer has been implicated in a myriad of membrane-related functions. As a cofactor for a variety of enzymes, PtdSer is thought to be important in cell excitability and communication. PtdSer has also been shown to regulate a variety of neuroendocrine responses that include the release of acetylcholine, dopamine and noradrenaline. Additionally, PtdSer has been extensively demonstrated to influence tissue responses to inflammation. Finally, PtdSer has the potential to act as an effective antioxidant, especially in response to iron-mediated oxidation. The majority of the available research that has investigated the effects of PtdSer supplementation on humans has concentrated on memory and cognitive function; patients experiencing some degree of cognitive decline have traditionally been the main focus of investigation. Although investigators have administered PtdSer through intravenous and oral routes, oral supplementation has wider appeal. Indeed, PtdSer is commercially available as an oral supplement intended to improve cognitive function, with recommended doses usually ranging from 100 to 500 mg/day. The main sources that have been used to derive PtdSer for supplements are bovine-cortex (BC-PtdSer) and soy (S-PtdSer); however, due to the possibility of transferring infection through the consumption of prion contaminated brain, S-PtdSer is the preferred supplement for use in humans. Although the pharmacokinetics of PtdSer have not been fully elucidated, it is likely that oral supplementation leads to small but quantifiable increases in the PtdSer content within the cell membrane.A small number of peer-reviewed full articles exist that investigate the effects of PtdSer supplementation in the exercising human. Early research indicated that oral supplementation with BC-PtdSer 800 mg/day moderated exercise-induced changes to the hypothalamo-pituitary-adrenal axis in untrained participants. Subsequently, this finding was extended to suggest that S-PtdSer 800 mg/day reduced the cortisol response to overtraining during weight training while improving feeling of well-being and decreasing perceived muscle soreness. However, equivocal findings from our laboratory might suggest that the dose required to undertake this neuroendocrine action may vary between participants.Interestingly, recent findings demonstrating that short-term supplementation with S-PtdSer 750 mg/day improved exercise capacity during high-intensity cycling and tended to increase performance during intermittent running might suggest an innovative application for this supplement. With the findings from the existing body of literature in mind, this article focuses on the potential effects of PtdSer supplementation in humans during and following exercise.

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Section: Neuroendocrinological Regulationmentioning

confidence: 91%

Section: Neuroendocrinological Regulationmentioning

confidence: 99%

Section: Fate Of Exogenous Phosphatidylserinementioning

confidence: 99%

mentioning

confidence: 99%

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Effects of Phosphatidylserine Supplementation on Exercising Humans

Kingsley

2006

Sports Medicine

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“…[45][46][47][48][49] Conversely, orally administered Phosphatidylserine was extensively hydrolyzed by phospholipase A 2 to lysophosphatidylserine in the gastrointestinal tract prior to absorption, as is the case for all other dietary phospholipids. 45,50,51 In rats, approximately 60% of an orally administered dose of Phosphatidylserine (20 mg/kg body weight) was recovered in the feces, of which 50% was identified as lysophosphatidylserine. Approximately 10% of the orally administered dose was detected in the urine.…”

Section: Nonhumanmentioning

confidence: 99%

Safety Assessment of Lecithin and Other Phosphoglycerides as Used in Cosmetics

Johnson¹,

Bergfeld²,

Belsito³

et al. 2020

Int J Toxicol

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The phosphoglycerides considered in this safety assessment are reported to function primarily as skin and hair conditioning agents, emulsifying agents, and surfactants in cosmetic products and are used up to a maximum reported concentration of 50%. Although phospholipids exert physiologic effects, these are not reproduced by application of phospholipid ingredients to the skin. Given the possibility that Lecithin may be derived from animal sources, it should be noted that the Food and Drug Administration does not permit the use of ingredients made from bovine specified risk materials in cosmetic products. The Expert Panel for Cosmetic Ingredient Safety concluded that the 17 phosphoglycerides are safe in the present practices of use and concentration in cosmetics, as described in this safety assessment.

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Effects of Exogenous Phosphatidylserine on Cognitive Functions and Phospholipid Metabolism in the Hippocampus of Aged Rats

Babenko

Semenova

2010

Neurosci Behav Physi

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Phospholipid Metabolism in Rat Intestinal Mucosa After Oral Administration of Lysophospholipids

Cited by 6 publications

References 16 publications

Effects of Phosphatidylserine Supplementation on Exercising Humans

Effects of Phosphatidylserine Supplementation on Exercising Humans

Safety Assessment of Lecithin and Other Phosphoglycerides as Used in Cosmetics

Effects of Exogenous Phosphatidylserine on Cognitive Functions and Phospholipid Metabolism in the Hippocampus of Aged Rats

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