Phospholipids and amino-acid composition of eggs of sea urchin from Barents Sea

Shikov, AN; Laakso, Into; Pozharitskaya, ON; Makarov, VG; Hiltunen, R.

doi:10.1055/s-0032-1320695

Cited by 4 publications

(6 citation statements)

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“…Analysis of lipid classes showed two major phospholipids—i.e., phosphatidylcholine and phosphatidylethanolamine. This data is in general agreement with the phospholipids profile of gonads of S. droebachiensis [ 7 ].…”

Section: Discussionsupporting

confidence: 89%

“…The gonads are delicacies in many parts of the world and considered as highly valued seafood. Several studies have indicated that the gonads of S. droebachiensis are rich in important bioactive compounds like polyunsaturated fatty acids (PUFA), phospholipids, tocopherols, sterols [ 2 , 3 , 4 ], carotenoids [ 2 , 5 ], and amino acids [ 6 , 7 ]. Extract of gonad tissue has also revealed effective anti-inflammatory and antidiabetic properties [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Chemical Profiling and Bioactivity of Body Wall Lipids from Strongylocentrotus droebachiensis

Shikov¹,

Laakso

Pozharitskaya³

et al. 2017

Marine Drugs

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The lipids from gonads and polyhydroxynaphthoquinone pigments from body walls of sea urchins are intensively studied. However, little is known about the body wall (BW) lipids. Ethanol extract (55 °C) contained about equal amounts of saturated (SaFA) and monounsaturated fatty acids (MUFA) representing 60% of total fatty acids, with myristic, palmitic and eicosenoic acids as major SaFAs and MUFAs, respectively. Non-methylene-interrupted dienes (13%) were composed of eicosadienoic and docosadienoic acids. Long-chain polyunsaturated fatty acids (LC-PUFA) included two main components, n6 arachidonic and n3 eicosapentaenoic acids, even with equal concentrations (15 μg/mg) and a balanced n6/n3 PUFA ratio (0.86). The UPLC-ELSD analysis showed that a great majority of the lipids (80%) in the ethanolic extract were phosphatidylcholine (60 μg/mg) and phosphatidylethanolamine (40 μg/mg), while the proportion of neutral lipids remained lower than 20%. In addition, alkoxyglycerol derivatives—chimyl, selachyl, and batyl alcohols—were quantified. We have assumed that the mechanism of action of body wall lipids in the present study is via the inhibition of MAPK p38, COX-1, and COX-2. Our findings open the prospective to utilize this lipid fraction as a source for the development of drugs with anti-inflammatory activity.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Chemical Profiling and Bioactivity of Body Wall Lipids from Strongylocentrotus droebachiensis

Shikov¹,

Laakso

Pozharitskaya³

et al. 2017

Marine Drugs

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“…Gonads of green sea urchin are rich in valuable bioactive compounds, such as polyunsaturated fatty acids (PUFAs) (González-Durán, Castell, Robinson, & Blair, 2008;Liyana-Pathirana, Shahidi, & Whittick, 2002a;Takagi, Eaton, & Ackman, 1980), carotenoids (Liyana-Pathirana, Shahidi, Whittick, & Hooper, 2002bMatsuno & Tsushima, 2001), phospholipids (Shikov, Laakso, Pozharitskaya, Makarov, & Hiltunen, 2012), and sulphated fucans (Vilela-Silva, Castro, Valente, Biermann, & Mourão, 2002).…”

Section: Introductionmentioning

confidence: 99%

Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea

Pozharitskaya¹,

Shikov²,

Laakso

et al. 2015

Journal of Functional Foods

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“…Ýêñòðàêò ñòàíäàðòèçèðîâàëè ïî ñëåäóþùèì ïîêà-çàòåëÿì: ñâîáîäíûå aeèðíûå êèñëîòû (60 %), ôîñôîëè-ïèäû -18,7 %; ïåïòèäû è àìèíîêèñëîòû -20 %; êà-ðîòèíîèäû -0,3 %, òîêîôåðîëû -0,4 % [12,13].…”

Section: ýêCïåpèìåíòàëüíàÿ è êëèíè÷åCêàÿ ôàPìàêîëîãèÿ 2015 òîì 78 ¹ 5unclassified

“…Îäíîé èç îñíîâíûõ ãðóïï áèîëîãè÷åñêè àêòèâíûõ âåùåñòâ êîìïëåêñà ãîíàä ìîðñêèõ åaeåé ÿâëÿþòñÿ ëè-ïèäû (60 %) ñ ïðåâàëèðîâàíèåì íåíàñûùåííûõ è ïî-ëèíåíàñûùåííûõ aeèðíûõ êèñëîò (AEÊ): 20:5n-3 (14,3 %), 20:3n-6 è 20:2n-6 (7,6 %), 20:1n-9 (6 %) [12] è ôîñôîëèïèäû (18,7 %), ñðåäè êîòîðûõ èäåíòèôèöèðî-âàíû ôîñôàòèäèýòàíîëàìèí, ôîñôàòèäèëèíîçèòîë, ôîñôàòèäèëõîëèí, ñôèíãîìèåëèí è ëèçîôîñôàòèäèë-õîëèí [13].…”

Section: ðåçóëüòàòû è èõ îáñóAeäåíèåunclassified

Эффективность Стандартизированного Экстракта Из Гонад Зеленых Морских Ежей На Экспериментальной Модели Метаболического Синдрома

Пожарицкая¹,

Шиков²,

Макарова³

et al. 2015

Эксп. и клин. фармакол.

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Â äîêëèíè÷åñêèõ èññëåäîâàíèÿõ, ïðîâåäåííûõ íà ñïîíòàííî ãèïåðòåíçèâíûõ êðû-ñàõ, âïåðâûå óñòàíîâëåíî, ÷òî ïðîôèëàêòè÷åñêîå ââåäåíèå ñòàíäàðòèçèðîâàííîãî ýê-ñòðàêòà èç ãîíàä ìîðñêèõ åaeåé â äîçàõ 0,37 è 0,74 ìã/êã ïðè âíóòðèáðþøèííîì ââåäå-íèè â òå÷åíèå 34 ñóò ñíèaeàåò óðîâåíü ãëþêîçû â êðîâè (ïðàêòè÷åñêè äî óðîâíÿ íîð-ìû) ýôôåêòèâíåå, ÷åì ïðåïàðàò ñðàâíåíèÿ ìåòôîðìèí, à òàêaeå óðîâåíü ãëèêîçèëèðî-âàííîãî ãåìîãëîáèíà, ïðåäîòâðàùàåò óìåíüøåíèå äèàìåòðà îñòðîâêîâ Ëàíãåðãàíñà è îáëàäàåò âûðàaeåííûì àíòèãèïåðòåíçèâíûì äåéñòâèåì. Íà ìîäåëè ñòðåïòîçîòîöèíî-âîãî äèàáåòà 2 òèïà ñòàíäàðòèçèðîâàííûé ýêñòðàêò ãîíàä ìîðñêèõ åaeåé ïðîÿâëÿåò àê-òèâíîñòü â äîçå 0,74 ìã/êã ïðè âíóòðèáðþøèííîì ââåäåíèè, ñðàâíèìóþ ñ äåéñòâèåì ïðåïàðàòà ñðàâíåíèÿ ìåòôîðìèíà â äîçå 100 ìã/êã.Êëþ÷åâûå ñëîâà: ñòàíäàðòèçèðîâàííûé ýêñòðàêò èç ãîíàä ìîðñêèõ åaeåé; äèàáåò; ãè-ïåðòåíçèÿ; ýêñïåðèìåíòàëüíàÿ ôàðìàêîëîãèÿ; ìåòàáîëè÷åñêèé ñèíäðîì. ÂÂÅÄÅÍÈÅÌåòàáîëè÷åñêèé ñèíäðîì (ÌÑ) ÿâëÿåòñÿ îäíîé èç àêòóàëüíûõ ìåäèêî-ñîöèàëüíûõ ïðîáëåì. Øèðîêàÿ ðàñïðîñòðàíåííîñòü ÌÑ, åãî ðîëü â ðàçâèòèè êîìîð-áèäíûõ çàáîëåâàíèé -ñàõàðíîãî äèàáåòà 2 òèïà (ÑÄ2), àðòåðèàëüíîé ãèïåðòåíçèè (ÀÃ), äèñëèïèäå-ìèè, àòåðîñêëåðîçà íå âûçûâàåò ñîìíåíèé è îïðåäåëÿ-åò èíòåíñèâíîñòü íàó÷íûõ ïîèñêîâ êëþ÷åâûõ çâåíüåâ ïàòîãåíåçà, äèàãíîñòèêè, ïðîôèëàêòèêè è ëå÷åíèÿ ýòî-ãî ñèìïòîìîêîìïëåêñà [8].Ñòðàòåãèÿ ëå÷åíèÿ ÌÑ âêëþ÷àåò â ñåáÿ èçìåíåíèå îáðàçà aeèçíè, ëå÷åíèå îaeèðåíèÿ, òåðàïèþ èíñóëèíî-ðåçèñòåíòíîñòè (ÈÐ) è ãèïåðãëèêåìèè, ëå÷åíèå àðòå-ðèàëüíîé ãèïåðòîíèè è äèñëèïèäåìèè. Äëÿ êàaeäîãî èç ýòèõ çàáîëåâàíèé ñóùåñòâóåò ðÿä ëåêàðñòâåííûõ ñðåäñòâ, ñïîñîáíûõ â òîé èëè èíîé ñòåïåíè êîìïåíñè-ðîâàòü êàaeäóþ îòäåëüíóþ ïðîáëåìó [4]. Îäíàêî êîì-ïëåêñíûõ ïðåïàðàòîâ, ñïîñîáíûõ óðåãóëèðîâàòü âñå îñíîâíûå ïàòîëîãè÷åñêèå ïðîöåññû ìåòàáîëè÷åñêîãî ñèíäðîìà, íà äàííûé ìîìåíò íåò, ÷òî ñòèìóëèðóåò ïî-èñê íîâûõ ïðåïàðàòîâ.Ïðîäóêòû ïåðåðàáîòêè ðûáû è ãèäðîáèîíòîâ ÿâëÿ-þòñÿ áîãàòûì èñòî÷íèêîì ïîëèíåíàñûùåííûõ aeèð-íûõ êèñëîò, â îñíîâíîì, w-3 è w-6, êîòîðûå, êàê ïîëà-ãàþò, ñïîñîáñòâóþò ñíèaeåíèþ ÷àñòîòû ñåðäå÷íî-ñîñó-äèñòûõ çàáîëåâàíèé, à òàêaeå îêàçûâàþò ïîëîaeèòåëü-íîå âëèÿíèå íà îðãàíèçì ïðè ãèïåðòîíèè, âîñïàëåíèè, àðèòìèè, ïñîðèàçå è îïóõîëÿõ. Îñîáûé èíòåðåñ äëÿ âûäåëåíèÿ êîìïëåêñà áèîëîãè÷åñêè àêòèâíûõ âåùåñòâ äëÿ ëå÷åíèÿ äèàáåòà ïðåäñòàâëÿþò ãîíàäû ìîðñêîãî åaeà Strongylocentrotus droebachiensis. Ñîäåðaeàùèåñÿ â ãîíàäàõ ìîðñêèõ åaeåé ïîëèíåíàñûùåííûå aeèðíûå êèñëîòû èçâåñòíû ñâîèìè ãèïîëèïèäåìè÷åñêèìè, àí-òèàòåðîãåííûìè, ãèïîòåíçèâíûìè, òðîìáîëèòè÷åñêè-ìè ýôôåêòàìè, ñïîñîáíîñòüþ óëó÷øàòü ôóíêöèþ ýí-äîòåëèÿ. Ýéêîçîïåíòàåíîâàÿ êèñëîòà, ñîäåðaeàùàÿñÿ â ãîíàäàõ ìîðñêèõ åaeåé, ñíèaeàåò ñèíòåç òðèãëèöåðèäîâ è õîëåñòåðèíà, óìåíüøàåò ñâåðòûâàåìîñòü êðîâè è ïðåäîòâðàùàåò îáðàçîâàíèå òðîìáîâ [2,14]. Â ãîíàäàõ ìîðñêèõ åaeåé îáíàðóaeåíû êàðîòèíîèäû, êîòîðûå çà-ùèùàþò ìåìáðàíû êëåòîê îò ðàçðóøåíèÿ àêòèâíûìè ôîðìàìè êèñëîðîäà, ñâîáîäíûìè ðàäèêàëàìè ïðè îêèñëèòåëüíîì ñòðåññå, ïîýòîìó îíè èñïîëüçóþòñÿ äëÿ ëå÷åíèÿ è ïðîôèëàêòèêè ñåðäå÷íî-ñîñóäèñòûõ çà-áîëåâàíèé [7].Â ýòîé ñâÿçè ïîèñê íîâûõ ñðåäñòâ äëÿ ïåðîðàëüíîãî ïðèìåíåíèÿ ìóëüòè...

show abstract

Phospholipids and amino-acid composition of eggs of sea urchin from Barents Sea

Cited by 4 publications

References 0 publications

Chemical Profiling and Bioactivity of Body Wall Lipids from Strongylocentrotus droebachiensis

Chemical Profiling and Bioactivity of Body Wall Lipids from Strongylocentrotus droebachiensis

Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea

Эффективность Стандартизированного Экстракта Из Гонад Зеленых Морских Ежей На Экспериментальной Модели Метаболического Синдрома

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