Phospholipids as ion exchangers: Implications for a possible role in biological membrane excitability and anesthesia

Blaustein, Mordecai P.

doi:10.1016/0005-2736(67)90096-x

Cited by 110 publications

(14 citation statements)

References 36 publications

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“…We find that, in high doses, DPH increases the uptake of Ca, which would agree with the studies of Blaustein (1967). However, these changes could not be compatible with the antiarrhythmic properties of DPH since the antiarrhythmic effects were observed at a DPH concentration in which calcium changes were not observed.…”

Section: Discussionsupporting

confidence: 76%

The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea‐pig heart

Baskin

Dutta

Marks

1973

British J Pharmacology

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Summary1. Diphenylhydantoin (DPH) and potassium significantly prevent ouabain intoxication without preventing the inotropic effects of ouabain in the guineapig isolated heart. 2. The antiarrhythmic effect of DPH and K on ouabain-induced toxicity appears to be related to their ability to reduce ouabain accumulation by the myocardium and thereby prevent the intracellular Na and K changes which lead to the arrhythmic state.

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Section: Discussionsupporting

confidence: 76%

The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea‐pig heart

Baskin

Dutta

Marks

1973

British J Pharmacology

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“…A similar sequence of potency was demonstrated when studies were made of the effect of these cations on membrane resistance at the Ranvier node (Khodorov & Peganov, 1969), on the increase of permeability of the lobster axon membrane (Blaustein & Goldman, 1968), as well as on their binding to the phospholipids of the cell membrane fraction and phosphatidylserine (Blaustein, 1967).…”

Section: Discussionmentioning

confidence: 84%

“…Manthey (1966) considers the interference of Ca2+ with the interaction between ACh and the receptor to be the most plausible explanation of this phenomenon. A less specific effect of Ca +, involving changes of the membrane permeability caused by the interaction of Ca2+ with membrane phospholipids (Abood, Koyama & Kimizuka, 1963;Blaustein, 1967) could also explain the influence of the ion on desensitization. Therefore it was L. G. MAGAZANIK AND F. VYSKO(IL of interest to learn how other multivalent cations, which differ from Ca2+ in their interaction with phospholipids, influence the rate of desensitization.…”

Section: G Magazanik and F Vyskocilmentioning

confidence: 99%

Dependence of acetylcholine desensitization on the membrane potential of frog muscle fibre and on the ionic changes in the medium

Lg¹,

Vyskočil²

1970

The Journal of Physiology

167

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SUMMARY1. The rate of desensitization of the post-synaptic membrane to prolonged action of acetylcholine was investigated during (a) potassium depolarization of the frog muscle fibre, (b) artificial changes of the membrane potential and (c) in the presence of some multivalent cations and of caffeine.2. Depolarization of the muscle fibre by 15 mM-K+ led to a slowing down in the development of desensitization by 80 %. This effect on desensitization produced by membrane potential changes could account for the previously described effect of increased K+ concentration. 3. Electrotonically produced depolarization of the muscle fibre membrane resulted in a decrease, hyperpolarization in an increase of the rate of desensitization.4. Several multivalent cations can be, according to their ability to increase rate of desensitization, arranged in the following series: Mg2+ < Ca2+ < Ba2+ < Sr2+ < A13+ < LaS+ 5. Caffeine in a concentration of 115 mm does not affect the rate of desensitization.6. A hypothesis is presented suggesting that desensitization is not only restricted to the receptor level but that it also occurs, at least partly, at the terminal stages of the activation system.

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“…Exchange reactions could possibly play an important part since the selective movement of ions depends upon the ionic groups of the membranes (163,164). Recent studies (159,163) with phospholipids show that they have defined ion-exchange properties which may depend upon the orientation and spacing of the molecules. The preparation of mosaic membranes with cation and anion exchangers adjacent to one another was developed by De Kcrosy et al (165) and Botrk et al (166).…”

Section: Discussionmentioning

confidence: 99%

Phospholipid Cell-Membrane Models

Castleden

1969

Journal of Pharmaceutical Sciences

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Phospholipids as ion exchangers: Implications for a possible role in biological membrane excitability and anesthesia

Cited by 110 publications

References 36 publications

The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea‐pig heart

The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea‐pig heart

Dependence of acetylcholine desensitization on the membrane potential of frog muscle fibre and on the ionic changes in the medium

Phospholipid Cell-Membrane Models

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